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SDS serine dehydratase [ Homo sapiens (human) ]

Gene ID: 10993, updated on 5-Mar-2024

Summary

Official Symbol
SDSprovided by HGNC
Official Full Name
serine dehydrataseprovided by HGNC
Primary source
HGNC:HGNC:10691
See related
Ensembl:ENSG00000135094 MIM:182128; AllianceGenome:HGNC:10691
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDH
Summary
This gene encodes one of three enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver. [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 130.0) and brain (RPKM 4.0) See more
Orthologs
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Genomic context

Location:
12q24.13
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (113392445..113403887, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (113369072..113380515, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (113830250..113841692, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:113736197-113736894 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:113736895-113737590 Neighboring gene Sharpr-MPRA regulatory region 468 Neighboring gene NANOG hESC enhancer GRCh37_chr12:113740736-113741469 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:113744904-113746103 Neighboring gene solute carrier family 8 member B1 Neighboring gene MPRA-validated peak1972 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4893 Neighboring gene uncharacterized LOC105369989 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4895 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:113797151-113797650 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:113801516-113802016 Neighboring gene phospholipase B domain containing 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:113818149-113818674 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7074 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:113839129-113839630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:113839631-113840130 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:113851189-113851372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:113855942-113856442 Neighboring gene serine dehydratase like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:113905667-113906660 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:113908758-113909558 Neighboring gene LIM homeobox 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-serine ammonia-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables L-serine ammonia-lyase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables threonine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in L-serine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in L-serine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in isoleucine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in pyruvate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in threonine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
L-serine dehydratase/L-threonine deaminase
Names
L-serine ammonia-lyase
L-serine deaminase
L-serine dehydratase
L-threonine dehydratase
TDH
NP_006834.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006843.3NP_006834.2  L-serine dehydratase/L-threonine deaminase

    See identical proteins and their annotated locations for NP_006834.2

    Status: REVIEWED

    Source sequence(s)
    BC020750, BG534053, BG566257, BU740747, J05037
    Consensus CDS
    CCDS9169.1
    UniProtKB/Swiss-Prot
    A8K9P5, P20132
    Related
    ENSP00000257549.4, ENST00000257549.9

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    113392445..113403887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    113369072..113380515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)