Zfp91 zinc finger protein 91 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp91provided by MGI
Official Full Name: zinc finger protein 91provided by MGI
Primary source: MGI:MGI:104854
See related: Ensembl:ENSMUSG00000024695 AllianceGenome:MGI:104854
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pzf; Zfp-91; 9130014I08Rik; A530054C17Rik
Summary: The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. The homologous human protein has been shown to function as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. A read-through transcript variant composed of Zfp91 and the downstream Cntf gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of Zfp91 and Cntf has been observed in both human and mouse. A Zfp91-related pseudogene has also been identified on chromosome 17. [provided by RefSeq, Oct 2010]
Expression: Ubiquitous expression in testis adult (RPKM 19.5), bladder adult (RPKM 15.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 8.73 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (12744303..12773487, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (12766939..12796123, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Convallatoxin inhibits IL-1beta production by suppressing zinc finger protein 91 (ZFP91)-mediated pro-IL-1beta ubiquitination and caspase-8 inflammasome activity.
Title: Convallatoxin inhibits IL-1β production by suppressing zinc finger protein 91 (ZFP91)-mediated pro-IL-1β ubiquitination and caspase-8 inflammasome activity.
Functional analysis of the human ZFP91 protein.
Title: Zinc-finger protein 91 plays a key role in LIGHT-induced activation of non-canonical NF-κB pathway.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124465 (e-PCR)
- UniSTS:161287

RH125517 (e-PCR)
- UniSTS:162334

Cntf (e-PCR), detects polymorphism
- UniSTS:507986

AW545902 (e-PCR)
- UniSTS:181210

RH139834 (e-PCR)
- UniSTS:221918

Readthrough Gm44505

Readthrough gene: Gm44505, Included gene: Cntf

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of NF-kappaB-inducing kinase activity	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase ZFP91

Names: RING-type E3 ubiquitin transferase ZFP91; penta Zf protein; zinc finger protein 91 homolog

NP_443735.2

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.