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Akp1 alkaline phosphatase 1 [ Mus musculus (house mouse) ]

Gene ID: 109899, updated on 7-Sep-2023

Summary

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Official Symbol
Akp1provided by MGI
Official Full Name
alkaline phosphatase 1provided by MGI
Primary source
MGI:MGI:87982
See related
AllianceGenome:MGI:87982
Gene type
protein coding
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Akp-1
Summary
Predicted to enable alkaline phosphatase activity. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
not in current annotation release
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Genomic context

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Location:
chromosome: 1

Bibliography

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Related articles in PubMed

  1. A new variant of the mouse Akp1 locus. Lee CH, et al. Biochem Genet, 2005 Dec. PMID 16382364
  2. Nuclear matrix-targeting of the osteogenic factor Runx2 is essential for its recognition and activation of the alkaline phosphatase gene. Weng JJ, et al. Biochim Biophys Acta, 2013 Mar. PMID 23287548
  3. Immunohistochemical expression of hard tissue related factors in the mouse dental pulp after immediate teeth separation. Nabeyama A, et al. Eur J Med Res, 2011 Nov 10. PMID 22027645, Free PMC Article
  4. Functional role of acetylcholine and the expression of cholinergic receptors and components in osteoblasts. Sato T, et al. FEBS Lett, 2010 Feb 19. PMID 20067796
  5. Uptake of nickel from 316L stainless steel into contacting osteoblastic cells and metal ion interference with BMP-2-induced alkaline phosphatase. Mölders M, et al. J Biomed Mater Res A, 2007 Nov. PMID 17437303

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ALP is a direct target gene of Runx2; the recognition/binding and activation of the ALP by this transcription factor are dependent on its nuclear matrix targeting.
    Title: Nuclear matrix-targeting of the osteogenic factor Runx2 is essential for its recognition and activation of the alkaline phosphatase gene.
  2. Change of Runx2 and ALP expression in mouse tooth pulp which exposed to teeth separation, was examined.
    Title: Immunohistochemical expression of hard tissue related factors in the mouse dental pulp after immediate teeth separation.
  3. Data show that ACh reduced alkaline phosphatase (ALP) activity in osteoblasts.
    Title: Functional role of acetylcholine and the expression of cholinergic receptors and components in osteoblasts.
  4. Results show that cells contacting 316L steel are exposed to increased concentrations of Ni which suffice to impair BMP-2-induced ALP activity.
    Title: Uptake of nickel from 316L stainless steel into contacting osteoblastic cells and metal ion interference with BMP-2-induced alkaline phosphatase.
  5. Essential role of Wnt3a-mediated activation of mitogen-activated protein kinase p38 for the stimulation of alkaline phosphatase activity and matrix mineralization in C3H10T1/2 mesenchymal cells.
    Title: Essential role of Wnt3a-mediated activation of mitogen-activated protein kinase p38 for the stimulation of alkaline phosphatase activity and matrix mineralization in C3H10T1/2 mesenchymal cells.
  6. reduced ALP activity after skeletal unloading is closely correlated with reduced expression of PECAM-1 in bone marrow cells
    Title: Reduced expression of platelet endothelial cell adhesion molecule-1 in bone marrow cells in mice after skeletal unloading.
  7. It was therefore concluded that AKP1C type is controlled by Akp1c allele which is codominant with Akp1a and Akp1b alleles.
    Title: A new variant of the mouse Akp1 locus.
  8. Alkaline phosphatase was determined in gonocytes with and without treatment by tetradecanoylphorbol acetate. The enzyme was elevated in treated cells.
    Title: Continuing primordial germ cell differentiation in the mouse embryo is a cell-intrinsic program sensitive to DNA methylation.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alkaline phosphatase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
alkaline phosphatase 1

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