U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Clps colipase, pancreatic [ Mus musculus (house mouse) ]

Gene ID: 109791, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Clpsprovided by MGI
Official Full Name
colipase, pancreaticprovided by MGI
Primary source
MGI:MGI:88421
See related
Ensembl:ENSMUSG00000024225 AllianceGenome:MGI:88421
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2200003J09Rik
Summary
This gene encodes a member of the colipase family of coenzymes that is required for the optimal activity of pancreatic lipase. The encoded protein undergoes proteolytic processing to generate a mature polypeptide that binds to the lipase and prevents inhibition by bile acids. Over half of the mice lacking the encoded protein die within two weeks of birth while the remaining ones exhibit fat malabsorption and altered body weight regulation. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015]
Expression
Restricted expression toward stomach adult (RPKM 112946.0) See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Clps in Genome Data Viewer
Location:
17 A3.3; 17 14.76 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (28777184..28779740, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (28558210..28560766, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41506 Neighboring gene armadillo repeat containing 12 Neighboring gene STARR-seq mESC enhancer starr_42217 Neighboring gene colipase-like 2 Neighboring gene microRNA 6969 Neighboring gene STARR-seq mESC enhancer starr_42221 Neighboring gene lipoma HMGIC fusion partner-like 5 Neighboring gene STARR-seq mESC enhancer starr_42224 Neighboring gene serine/arginine-rich protein specific kinase 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Enterostatin deficiency increases serum cholesterol but does not influence growth and food intake in mice. Miller R, et al. Am J Physiol Endocrinol Metab, 2009 Oct. PMID 19622781, Free PMC Article
  2. Decreased postnatal survival and altered body weight regulation in procolipase-deficient mice. D'Agostino D, et al. J Biol Chem, 2002 Mar 1. PMID 11751900, Free PMC Article
  3. The mPlrp2 and mClps genes are involved in the hydrolysis of retinyl esters in the mouse liver. Pang W, et al. J Lipid Res, 2011 May. PMID 21339507, Free PMC Article
  4. Assignment of the human pancreatic colipase gene to chromosome 6p21.1 to pter. Davis RC, et al. Genomics, 1991 May. PMID 2045105
  5. Quantitative trait loci for carbohydrate and total energy intake on mouse chromosome 17: congenic strain confirmation and candidate gene analyses (Glo1, Glp1r). Kumar KG, et al. Am J Physiol Regul Integr Comp Physiol, 2007 Jan. PMID 16946080

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that the conditional expression of mPlrp2 and mClps is involved in the hydrolysis of retinyl esters in the mouse liver.
    Title: The mPlrp2 and mClps genes are involved in the hydrolysis of retinyl esters in the mouse liver.
  2. colipase (-/-)mice develop diet-induced obesity, as do colipase (+/+) mice, and have normal responses to a two-macronutrient choice diet and to a switch from a high-fat to a low-fat diet
    Title: Enterostatin deficiency increases serum cholesterol but does not influence growth and food intake in mice.
  3. We conclude that, in addition to its critical role in fat digestion, procolipase has essential functions in postnatal development and in regulating body weight set point.
    Title: Decreased postnatal survival and altered body weight regulation in procolipase-deficient mice.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
  
enables lipase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within digestion IEA
Inferred from Electronic Annotation
more info
  
involved_in digestion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to food IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
colipase

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317065.1 → NP_001303994.1  colipase isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1.
    Source sequence(s)
    AK008815, BM570078, BQ126290
    Consensus CDS
    CCDS84287.1
    UniProtKB/TrEMBL
    B2KF29
    Related
    ENSMUSP00000110433.2, ENSMUST00000114785.3
    Conserved Domains (2) summary
    smart00023
    Location:19 → 72
    COLIPASE; Colipase
    cl24053
    Location:30 → 67
    COLIPASE; Colipase; a stoichiometric cofactor for pancreatic lipase, allowing the enzyme to anchor itself to the water-lipid interface and stabilizing the active enzyme conformation

  2. NM_025469.3 → NP_079745.1  colipase isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_079745.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK008815, BM570078, BQ126290
    Consensus CDS
    CCDS28581.1
    UniProtKB/Swiss-Prot
    Q8VHR2, Q8VHR3, Q9CQC2
    UniProtKB/TrEMBL
    Q9D2R7
    Related
    ENSMUSP00000025062.4, ENSMUST00000025062.5
    Conserved Domains (2) summary
    cd00039
    Location:19 → 108
    COLIPASE; Colipase; a stoichiometric cofactor for pancreatic lipase, allowing the enzyme to anchor itself to the water-lipid interface and stabilizing the active enzyme conformation
    smart00023
    Location:19 → 113
    COLIPASE; Colipase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    28777184..28779740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQC2.1 GenPept UniProtKB/Swiss-Prot:Q9CQC2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous