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Pgm3 phosphoglucomutase 3 [ Mus musculus (house mouse) ]

Gene ID: 109785, updated on 5-Mar-2024

Summary

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Official Symbol
Pgm3provided by MGI
Official Full Name
phosphoglucomutase 3provided by MGI
Primary source
MGI:MGI:97566
See related
Ensembl:ENSMUSG00000056131 AllianceGenome:MGI:97566
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Agm1; PAGM; Pgm-3; 2810473H05Rik
Summary
Enables phosphoacetylglucosamine mutase activity and phosphoglucomutase activity. Acts upstream of or within several processes, including UDP-N-acetylglucosamine biosynthetic process; glucose 1-phosphate metabolic process; and spermatogenesis. Is expressed in colon; metanephros; ovary; and testis. Human ortholog(s) of this gene implicated in immunodeficiency 23 and teratoma. Orthologous to human PGM3 (phosphoglucomutase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 9.9), CNS E18 (RPKM 5.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 E3.1; 9 46.58 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (86423997..86453927, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (86552476..86571878, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1553 Neighboring gene ribosomal protein L5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_24831 Neighboring gene STARR-seq mESC enhancer starr_24832 Neighboring gene sorting nexin 4 pseudogene Neighboring gene ubiquitin protein ligase E3D Neighboring gene DOP1 leucine zipper like protein A Neighboring gene STARR-positive B cell enhancer ABC_E9332 Neighboring gene STARR-positive B cell enhancer ABC_E10572 Neighboring gene RWD domain containing 2A Neighboring gene malic enzyme 1, NADP(+)-dependent, cytosolic Neighboring gene STARR-seq mESC enhancer starr_24835 Neighboring gene RIKEN cDNA A330041J22 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development. Greig KT, et al. Mol Cell Biol, 2007 Aug. PMID 17548465, Free PMC Article
  2. Genetic mapping and systematic screening of mouse endogenously imprinted loci detected with restriction landmark genome scanning method (RLGS). Shibata H, et al. Mamm Genome, 1994 Dec. PMID 7894162
  3. A null mutation at the mouse Phosphoglucomutase-1 locus and a new locus Pgm-3. Johnson FM, et al. Biochem Genet, 1981 Jun. PMID 6457600
  4. The Pk-3 gene determines both the heart, M1, and the kidney, M2, pyruvate kinase isozymes in the mouse; and a simple electrophoretic method for separating phosphoglucomutase-3. Peters J, et al. Biochem Genet, 1984 Dec. PMID 6241468
  5. A malic enzyme probe detects cross-hybridizing sequences closely linked to loci encoding other metabolic enzymes. Cobb RR, et al. Genomics, 1992 Feb. PMID 1346782

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables intramolecular phosphotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoacetylglucosamine mutase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoacetylglucosamine mutase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphoacetylglucosamine mutase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in UDP-N-acetylglucosamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within UDP-N-acetylglucosamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in UDP-N-acetylglucosamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within embryo development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hemopoiesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in organic substance metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
phosphoacetylglucosamine mutase
Names
GlcNAc-P mutase
N-acetylglucosamine-phosphate mutase
PGM 3
acetylglucosamine phosphomutase
NP_001157218.1
NP_082628.3
XP_030099867.1
XP_036010453.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163746.1 → NP_001157218.1  phosphoacetylglucosamine mutase isoform 2

    See identical proteins and their annotated locations for NP_001157218.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC157998, AK028066, AK043547, AK049758
    Consensus CDS
    CCDS52877.1
    UniProtKB/TrEMBL
    Q3TFH8, Q8BWW3, Q8BZ65
    Related
    ENSMUSP00000072390.7, ENSMUST00000072585.8
    Conserved Domains (2) summary
    cd03086
    Location:22 → 486
    PGM3; PGM3 (phosphoglucomutase 3), also known as PAGM (phosphoacetylglucosamine mutase) and AGM1 (N-acetylglucosamine-phosphate mutase), is an essential enzyme found in eukaryotes that reversibly catalyzes the conversion of GlcNAc-6-phosphate into ...
    PLN02895
    Location:1 → 497
    PLN02895; phosphoacetylglucosamine mutase

  2. NM_028352.4 → NP_082628.3  phosphoacetylglucosamine mutase isoform 1

    See identical proteins and their annotated locations for NP_082628.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC157998, AK028066, AK043547, AK160913
    Consensus CDS
    CCDS23381.1
    UniProtKB/Swiss-Prot
    B2RS40, Q543F9, Q9CYR6
    UniProtKB/TrEMBL
    Q3TFH8, Q8BZ65
    Related
    ENSMUSP00000070871.5, ENSMUST00000070064.11
    Conserved Domains (2) summary
    cd03086
    Location:22 → 527
    PGM3; PGM3 (phosphoglucomutase 3), also known as PAGM (phosphoacetylglucosamine mutase) and AGM1 (N-acetylglucosamine-phosphate mutase), is an essential enzyme found in eukaryotes that reversibly catalyzes the conversion of GlcNAc-6-phosphate into ...
    PLN02895
    Location:1 → 538
    PLN02895; phosphoacetylglucosamine mutase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    86423997..86453927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154560.1 → XP_036010453.1  phosphoacetylglucosamine mutase isoform X1

    UniProtKB/TrEMBL
    Q8BME1
    Conserved Domains (1) summary
    cd03086
    Location:22 → 513
    PGM3; PGM3 (phosphoglucomutase 3), also known as PAGM (phosphoacetylglucosamine mutase) and AGM1 (N-acetylglucosamine-phosphate mutase), is an essential enzyme found in eukaryotes that reversibly catalyzes the conversion of GlcNAc-6-phosphate into ...

  2. XM_030244007.2 → XP_030099867.1  phosphoacetylglucosamine mutase isoform X2

    Conserved Domains (1) summary
    cl38939
    Location:2 → 262
    phosphohexomutase; The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine ...

RNA

  1. XR_003947761.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CYR6.1 GenPept UniProtKB/Swiss-Prot:Q9CYR6

Gene LinkOut

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