Hyal3 hyaluronoglucosaminidase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hyal3provided by MGI
Official Full Name: hyaluronoglucosaminidase 3provided by MGI
Primary source: MGI:MGI:1330288
See related: Ensembl:ENSMUSG00000036091 AllianceGenome:MGI:1330288
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hyl3
Summary: Enables hyalurononglucosaminidase activity. Involved in several processes, including hyaluronan catabolic process; negative regulation of ovarian follicle development; and ovarian follicle atresia. Located in cytoplasmic vesicle; endoplasmic reticulum; and sperm midpiece. Is expressed in several structures, including cardiovascular system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human HYAL3 (hyaluronidase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 58.19 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (107458495..107464558)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (107581296..107587359)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that Hyal-1, but not Hyal-3,is an ovarian regulator factor for follicle development, and show an interrelationship between this enzyme and the follistatin/activin/Smad3 pathway.
Title: Hyal-1 but not Hyal-3 deficiency has an impact on ovarian folliculogenesis and female fertility by altering the follistatin/activin/Smad3 pathway and the apoptotic process.
Hyal3 null sperm showed delayed cumulus penetration and reduced acrosomal exocytosis.
Title: Acidic hyaluronidase activity is present in mouse sperm and is reduced in the absence of SPAM1: evidence for a role for hyaluronidase 3 in mouse and human sperm.
HYAL3 does not play a major role in constitutive hyaluronan degradation
Title: Hyaluronidase 3 (HYAL3) knockout mice do not display evidence of hyaluronan accumulation.
Hyaluronidase induces ovarian granulosa cell apoptosis and is involved in follicular atresia.
Title: Mammalian hyaluronidase induces ovarian granulosa cell apoptosis and is involved in follicular atresia.
Hyal3 may contribute to hyaluronan metabolism by augmenting the activity of Hyal1.
Title: Mouse Hyal3 encodes a 45- to 56-kDa glycoprotein whose overexpression increases hyaluronidase 1 activity in cultured cells.
Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3.
Title: Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

General gene information

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Markers

RH136004 (e-PCR)
- UniSTS:210000

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

AF011567 (e-PCR)
- UniSTS:163468

Hyal3 (e-PCR), detects polymorphism
- UniSTS:526014

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hyaluronoglucuronidase activity	ISO Inferred from Sequence Orthology more info
NOT enables hyalurononglucosaminidase activity	IDA Inferred from Direct Assay more info	PubMed
enables hyalurononglucosaminidase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
NOT enables virus receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV-B	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in hyaluronan catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hyaluronan catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in hyaluronan catabolic process	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ovarian follicle development	IDA Inferred from Direct Assay more info	PubMed
involved_in ovarian follicle atresia	IDA Inferred from Direct Assay more info	PubMed
involved_in penetration of zona pellucida	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of acrosomal vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within single fertilization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in acrosomal membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in acrosomal vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in sperm midpiece	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: hyaluronidase-3

Names: hyal-3

NP_821139.2

EC 3.2.1.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.