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Lmo1 LIM domain only 1 [ Mus musculus (house mouse) ]

Gene ID: 109594, updated on 5-Mar-2024

Summary

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Official Symbol
Lmo1provided by MGI
Official Full Name
LIM domain only 1provided by MGI
Primary source
MGI:MGI:102812
See related
Ensembl:ENSMUSG00000036111 AllianceGenome:MGI:102812
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ttg1; Rbtn1; Rbtn-1
Summary
Predicted to enable metal ion binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; and regulation of T cell homeostatic proliferation. Located in nucleus. Is expressed in several structures, including genitourinary system; hemolymphoid system; nervous system; respiratory system; and sensory organ. Orthologous to human LMO1 (LIM domain only 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 28.1), whole brain E14.5 (RPKM 23.1) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Lmo1 in Genome Data Viewer
Location:
7 E3; 7 57.21 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (108737776..108774356, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (109138565..109175207, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene TUB bipartite transcription factor Neighboring gene RIC3 acetylcholine receptor chaperone Neighboring gene predicted gene, 25450 Neighboring gene STARR-seq mESC enhancer starr_19793 Neighboring gene predicted gene 44781 Neighboring gene STARR-seq mESC enhancer starr_19794 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:116409223-116409433 Neighboring gene predicted gene, 32563 Neighboring gene predicted gene, 51463

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Segmental and developmental regulation of a presumptive T-cell oncogene in the central nervous system. Greenberg JM, et al. Nature, 1990 Mar 8. PMID 2106626
  2. Bivalent promoter marks and a latent enhancer may prime the leukaemia oncogene LMO1 for ectopic expression in T-cell leukaemia. Oram SH, et al. Leukemia, 2013 Jun. PMID 23302769, Free PMC Article
  3. scid Thymocytes with TCRbeta gene rearrangements are targets for the oncogenic effect of SCL and LMO1 transgenes. Chervinsky DS, et al. Cancer Res, 2001 Sep 1. PMID 11522630
  4. The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein. McGuire EA, et al. Mol Cell Biol, 1989 May. PMID 2501659, Free PMC Article
  5. Thymic overexpression of Ttg-1 in transgenic mice results in T-cell acute lymphoblastic leukemia/lymphoma. McGuire EA, et al. Mol Cell Biol, 1992 Sep. PMID 1508213, Free PMC Article

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SCL-LMO1 upregulated a stem cell gene signature in DN3 thymocytes.
    Title: SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cells.
  2. Loss of Lmo1 repression may be one of the causes accounting for the phenotypic differences identified between the Arx((GCG)7)and Arx(432-455dup24) mouse models.
    Title: Reduced polyalanine-expanded Arx mutant protein in developing mouse subpallium alters Lmo1 transcriptional regulation.
  3. SCL, LMO1, and Notch1 gain of function, together with an active pre-T-cell antigen receptor, might represent the minimum set of complementing events for the transformation of susceptible thymocytes into cancer cells
    Title: Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.
  4. Lmo1 takes part in a Hox paralogue 2-dependent network regulating anteroposterior and dorsoventral hindbrain patterning
    Title: Identification of Lmo1 as part of a Hox-dependent regulatory network for hindbrain patterning.
  5. Results suggest that all four members of the LIM-only family -- LMO1, 2, 3, and 4 -- are important regulators of distinct developmental pathways.
    Title: Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of T cell homeostatic proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
rhombotin-1
Names
LIM domain only protein 1
LIM only 1
T-cell translocation protein 1
cysteine-rich protein TTG-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302205.2 → NP_001289134.1  rhombotin-1 isoform 2

    See identical proteins and their annotated locations for NP_001289134.1

    Status: VALIDATED

    Source sequence(s)
    AC147221
    Consensus CDS
    CCDS85378.1
    UniProtKB/TrEMBL
    A0A140LIB4
    Related
    ENSMUSP00000146752.2, ENSMUST00000207178.2
    Conserved Domains (2) summary
    cd09388
    Location:23 → 77
    LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
    cd09389
    Location:87 → 141
    LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

  2. NM_001302206.2 → NP_001289135.1  rhombotin-1 isoform 3

    See identical proteins and their annotated locations for NP_001289135.1

    Status: VALIDATED

    Source sequence(s)
    AC147221
    Consensus CDS
    CCDS85377.1
    UniProtKB/TrEMBL
    A0A140LHX4
    Related
    ENSMUSP00000146588.2, ENSMUST00000208136.2
    Conserved Domains (2) summary
    cd09388
    Location:13 → 67
    LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
    cd09389
    Location:77 → 131
    LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

  3. NM_001382564.1 → NP_001369493.1  rhombotin-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC147221
    UniProtKB/Swiss-Prot
    Q924W9
    UniProtKB/TrEMBL
    Q3UZX1
    Conserved Domains (2) summary
    cd09388
    Location:24 → 78
    LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
    cd09389
    Location:88 → 142
    LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

  4. NM_057173.4 → NP_476514.1  rhombotin-1 isoform 1

    See identical proteins and their annotated locations for NP_476514.1

    Status: VALIDATED

    Source sequence(s)
    AC147221
    Consensus CDS
    CCDS40080.1
    UniProtKB/Swiss-Prot
    Q924W9
    UniProtKB/TrEMBL
    Q3UZX1
    Related
    ENSMUSP00000037079.8, ENSMUST00000036992.9
    Conserved Domains (2) summary
    cd09388
    Location:24 → 78
    LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
    cd09389
    Location:88 → 142
    LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    108737776..108774356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q924W9.1 GenPept UniProtKB/Swiss-Prot:Q924W9

Gene LinkOut

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