U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lmo3 LIM domain only 3 [ Mus musculus (house mouse) ]

Gene ID: 109593, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Lmo3provided by MGI
Official Full Name
LIM domain only 3provided by MGI
Primary source
MGI:MGI:102810
See related
Ensembl:ENSMUSG00000030226 AllianceGenome:MGI:102810
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lmo-3; Rbtn3; Rbtn-3
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in negative regulation of ERK1 and ERK2 cascade; positive regulation of glucocorticoid receptor signaling pathway; and positive regulation of peroxisome proliferator activated receptor signaling pathway. Predicted to be located in cytoplasm. Is expressed in several structures, including brain; cochlea; spinal cord; and vestibulo-cochlear ganglion. Orthologous to human LMO3 (LIM domain only 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 16.5), frontal lobe adult (RPKM 10.9) and 4 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
6 G1; 6 69.02 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (138339916..138559204, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (138362918..138582206, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr6:138096406-138096707 Neighboring gene microsomal glutathione S-transferase 1 Neighboring gene predicted gene, 30213 Neighboring gene RIKEN cDNA A830011K09 gene Neighboring gene predicted gene, 30332 Neighboring gene RIKEN cDNA B230110G15 gene Neighboring gene immunoglobulin (CD79A) binding protein 1b Neighboring gene protein inhibitor of activated STAT 2 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Increased behavioral responses to ethanol in Lmo3 knockout mice. Savarese A, et al. Genes Brain Behav, 2014 Nov. PMID 25176312, Free PMC Article
  2. LMO3 reprograms visceral adipocyte metabolism during obesity. Wagner G, et al. J Mol Med (Berl), 2021 Aug. PMID 34018016, Free PMC Article
  3. Regulation of anxiety-like behavior and Crhr1 expression in the basolateral amygdala by LMO3. Savarese A, et al. Psychoneuroendocrinology, 2018 Jun. PMID 29609111, Free PMC Article
  4. Bioluminescence-driven optogenetic activation of transplanted neural precursor cells improves motor deficits in a Parkinson's disease mouse model. Zenchak JR, et al. J Neurosci Res, 2020 Mar. PMID 29577367, Free PMC Article
  5. Oncogenic Lmo3 cooperates with Hen2 to induce hydrocephalus in mice. Isogai E, et al. Exp Anim, 2015. PMID 26156403, Free PMC Article

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The transcription regulator Lmo3 is required for the development of medial ganglionic eminence derived neurons in the external globus pallidus.
    Title: The transcription regulator Lmo3 is required for the development of medial ganglionic eminence derived neurons in the external globus pallidus.
  2. LMO3 reprograms visceral adipocyte metabolism during obesity.
    Title: LMO3 reprograms visceral adipocyte metabolism during obesity.
  3. These results suggest that Lmo3 promotes anxiety-like behavior specifically in the BLA, possibly by altering Crhr1 expression.
    Title: Regulation of anxiety-like behavior and Crhr1 expression in the basolateral amygdala by LMO3.
  4. suggested that the expression levels of Lmo3 and/or Hen2 could determine the fate of stem cells by inhibiting Hes1 function during nervous system development and might be a trigger of aberrant neurogenesis in vivo
    Title: Oncogenic Lmo3 cooperates with Hen2 to induce hydrocephalus in mice.
  5. These results support a role for LMO3 in regulating behavioral responses to ethanol, potentially through its actions in the nucleus accumbens.
    Title: Increased behavioral responses to ethanol in Lmo3 knockout mice.
  6. Gbx2 regulates thalamocortical axon guidance by modifying the LIM and Robo codes.
    Title: Gbx2 regulates thalamocortical axon guidance by modifying the LIM and Robo codes.
  7. when tested for behavioral responses to ethanol, transgenic mice exhibited altered ethanol sedation and consumption that correlated with Lmo3 expression levels; results suggest a role for Lmo3 in ethanol-related behaviors in mice
    Title: Lmo genes regulate behavioral responses to ethanol in Drosophila melanogaster and the mouse.
  8. Data show that the calcium- and integrin-binding protein CIB as an LMO3-binding protein, which binds via the second LIM domain (LIM2) of LMO3.
    Title: The oncoprotein LMO3 interacts with calcium- and integrin-binding protein CIB.
  9. Results suggest that all four members of the LIM-only family -- LMO1, 2, 3, and 4 -- are important regulators of distinct developmental pathways.
    Title: Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within exploration behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
NOT acts_upstream_of_or_within positive regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of glucocorticoid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
LIM domain only protein 3
Names
LIM only 3
neuronal-specific transcription factor DAT1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356305.2 → NP_001343234.1  LIM domain only protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121968, AC125215
    Consensus CDS
    CCDS20669.1
    UniProtKB/Swiss-Prot
    Q8BZL8
    Conserved Domains (2) summary
    cd09388
    Location:13 → 67
    LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
    cd09389
    Location:77 → 131
    LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

  2. NM_001356306.2 → NP_001343235.1  LIM domain only protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121968, AC125215
    Consensus CDS
    CCDS20669.1
    UniProtKB/Swiss-Prot
    Q8BZL8
    Related
    ENSMUSP00000125589.2, ENSMUST00000163024.8
    Conserved Domains (2) summary
    cd09388
    Location:13 → 67
    LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
    cd09389
    Location:77 → 131
    LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

  3. NM_001356307.2 → NP_001343236.1  LIM domain only protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC121968, AC125215
    Consensus CDS
    CCDS90132.1
    UniProtKB/TrEMBL
    E9PWI9
    Related
    ENSMUSP00000124762.2, ENSMUST00000163065.8
    Conserved Domains (2) summary
    cd09388
    Location:24 → 78
    LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
    cd09389
    Location:88 → 142
    LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

  4. NM_001411497.1 → NP_001398426.1  LIM domain only protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121968, AC125215
    UniProtKB/Swiss-Prot
    Q8BZL8

  5. NM_001411498.1 → NP_001398427.1  LIM domain only protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121968, AC125215
    UniProtKB/Swiss-Prot
    Q8BZL8
    Related
    ENSMUSP00000145048.2, ENSMUST00000203435.3

  6. NM_001411499.1 → NP_001398428.1  LIM domain only protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121968, AC125215
    UniProtKB/Swiss-Prot
    Q8BZL8

  7. NM_001411500.1 → NP_001398429.1  LIM domain only protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121968, AC125215
    UniProtKB/Swiss-Prot
    Q8BZL8
    Related
    ENSMUSP00000124862.2, ENSMUST00000161450.8

  8. NM_001411501.1 → NP_001398430.1  LIM domain only protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121968, AC125215
    UniProtKB/Swiss-Prot
    Q8BZL8

  9. NM_001411502.1 → NP_001398431.1  LIM domain only protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121968, AC125215
    UniProtKB/Swiss-Prot
    Q8BZL8

  10. NM_001411503.1 → NP_001398432.1  LIM domain only protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121968, AC125215
    UniProtKB/Swiss-Prot
    Q8BZL8

  11. NM_001411504.1 → NP_001398433.1  LIM domain only protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121968, AC125215
    UniProtKB/Swiss-Prot
    Q8BZL8

  12. NM_207222.4 → NP_997105.1  LIM domain only protein 3 isoform 1

    See identical proteins and their annotated locations for NP_997105.1

    Status: VALIDATED

    Source sequence(s)
    AC121968, AC125215, AC139755
    Consensus CDS
    CCDS20669.1
    UniProtKB/Swiss-Prot
    Q8BZL8
    Related
    ENSMUSP00000125335.2, ENSMUST00000162772.8
    Conserved Domains (2) summary
    cd09388
    Location:13 → 67
    LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
    cd09389
    Location:77 → 131
    LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

RNA

  1. NR_151448.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121968, AC125215

  2. NR_151449.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121968, AC125215

  3. NR_177275.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121968, AC125215

  4. NR_177276.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121968, AC125215

  5. NR_177277.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121968, AC125215

  6. NR_177278.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC121968, AC125215

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    138339916..138559204 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255087.1 → XP_030110947.1  LIM domain only protein 3 isoform X2

    UniProtKB/Swiss-Prot
    Q8BZL8
    Conserved Domains (2) summary
    cd09388
    Location:13 → 67
    LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
    cd09389
    Location:77 → 131
    LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

  2. XM_036165743.1 → XP_036021636.1  LIM domain only protein 3 isoform X1

    Conserved Domains (2) summary
    cd09388
    Location:40 → 94
    LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
    cd09389
    Location:104 → 158
    LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

  3. XM_006505343.5 → XP_006505406.1  LIM domain only protein 3 isoform X3

    Conserved Domains (2) summary
    cd09388
    Location:40 → 94
    LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
    cl02475
    Location:104 → 139
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RNA

  1. XR_377405.5 RNA Sequence

  2. XR_868844.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BZL8.1 GenPept UniProtKB/Swiss-Prot:Q8BZL8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous