U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

BTG3 BTG anti-proliferation factor 3 [ Homo sapiens (human) ]

Gene ID: 10950, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
BTG3provided by HGNC
Official Full Name
BTG anti-proliferation factor 3provided by HGNC
Primary source
HGNC:HGNC:1132
See related
Ensembl:ENSG00000154640 MIM:605674; AllianceGenome:HGNC:1132
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANA; TOB5; TOFA; APRO4; TOB55; ANA/BTG3
Summary
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Expression
Ubiquitous expression in testis (RPKM 24.4), placenta (RPKM 23.0) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
21q21.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (17593653..17612901, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (15948673..15970578, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (18965971..18985219, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13222 Neighboring gene RNA, 7SL, cytoplasmic 163, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:18900282-18901218 Neighboring gene basic transcription factor 3 like 4 pseudogene 1 Neighboring gene CXADR Ig-like cell adhesion molecule Neighboring gene BTG3 antisense RNA 1 Neighboring gene uncharacterized LOC124904999 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr21:19038958-19040157 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:19060700-19061602 Neighboring gene uncharacterized LOC124900465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18294 Neighboring gene C21orf91 overlapping transcript 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18295 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18296 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18297 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18298 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18299 Neighboring gene chromosome 21 open reading frame 91

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Hypoxia-induced downregulation of B-cell translocation gene 3 confers resistance to radiation therapy of colorectal cancer. Ma D, et al. J Cancer Res Clin Oncol, 2020 Oct. PMID 32620986
  2. The function of BTG3 in colorectal cancer cells and its possible signaling pathway. Lv C, et al. J Cancer Res Clin Oncol, 2018 Feb. PMID 29270670, Free PMC Article
  3. The suppressing effects of BTG3 expression on aggressive behaviors and phenotypes of colorectal cancer: An in vitro and vivo study. Zheng HC, et al. Oncotarget, 2017 Mar 14. PMID 28407690, Free PMC Article
  4. BTG3 Overexpression Suppresses the Proliferation and Invasion in Epithelial Ovarian Cancer Cell by Regulating AKT/GSK3β/β-Catenin Signaling. An Q, et al. Reprod Sci, 2017 Oct. PMID 28183228
  5. B-cell translocation gene 3 overexpression inhibits proliferation and invasion of colorectal cancer SW480 cells via Wnt/β-catenin signaling pathway. Mao D, et al. Neoplasma, 2016. PMID 27468874

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long noncoding RNA CA3-AS1 suppresses gastric cancer migration and invasion by sponging miR-93-5p and targeting BTG3.
    Title: Long noncoding RNA CA3-AS1 suppresses gastric cancer migration and invasion by sponging miR-93-5p and targeting BTG3.
  2. Correlation between BTG3, CASP9 and LRP4 single-nucleotide polymorphisms and susceptibility to papillary thyroid carcinoma.
    Title: Correlation between BTG3, CASP9 and LRP4 single-nucleotide polymorphisms and susceptibility to papillary thyroid carcinoma.
  3. Long non-coding RNA cancer susceptibility candidate 2 regulates the function of human fibroblast-like synoviocytes via the microRNA-18a-5p/B-cell translocation gene 3 signaling axis in rheumatoid arthritis.
    Title: Long non-coding RNA cancer susceptibility candidate 2 regulates the function of human fibroblast-like synoviocytes via the microRNA-18a-5p/B-cell translocation gene 3 signaling axis in rheumatoid arthritis.
  4. Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor microenvironment through HIF-1 activation.
    Title: Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor microenvironment through HIF-1 activation.
  5. Hypoxia-induced downregulation of B-cell translocation gene 3 confers resistance to radiation therapy of colorectal cancer.
    Title: Hypoxia-induced downregulation of B-cell translocation gene 3 confers resistance to radiation therapy of colorectal cancer.
  6. miR-519c-3p functions as a tumor promotor in regulating the growth and metastasis of hepatocellular carcinoma by targeting BTG3.
    Title: MicroRNA-519c-3p promotes tumor growth and metastasis of hepatocellular carcinoma by targeting BTG3.
  7. HOTAIRM1 might act as a tumor-suppressor in 5-fluorouracil resistant colorectal cancer cells in vitro and in vivo through downregulating miR-17-5p/BTG3 pathway and inhibiting multi-drug resistance.
    Title: The long non-coding RNA HOTAIRM1 suppresses cell progression via sponging endogenous miR-17-5p/ B-cell translocation gene 3 (BTG3) axis in 5-fluorouracil resistant colorectal cancer cells.
  8. Inhibition of miR-93-5p may have blocked HPV-positive cervical cancer development by targeting of BTG3.
    Title: Suppression of miR-93-5p inhibits high-risk HPV-positive cervical cancer progression via targeting of BTG3.
  9. BTG3 overexpression inhibited cell growth, induced cell cycle arrest and suppressed the metastasis of SW480 cells via the Wnt/beta-catenin signaling pathway. BTG3 may be considered as a therapeutic target in CRC treatment.
    Title: B-cell translocation gene 3 overexpression inhibits proliferation and invasion of colorectal cancer SW480 cells via Wnt/β-catenin signaling pathway.
  10. Data show that miR-139 can repress the proliferation of hepatocellular carcinoma (HCC) cells via directly inhibiting the expression of ANA protein, human Add B-cell translocation gene 3 protein (BTG3).
    Title: [microRNA-139 suppresses proliferation of hepatocellular carcinoma cells by silencing of B cell translocation gene 3].
Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC8928

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein BTG3
Names
B-cell translocation gene 3
BTG family member 3
abundant in neuroepithelium area protein
protein Tob5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130914.2 → NP_001124386.1  protein BTG3 isoform a

    See identical proteins and their annotated locations for NP_001124386.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK289408, BC011957, BF110486, DA381239
    Consensus CDS
    CCDS46636.1
    UniProtKB/Swiss-Prot
    Q14201
    UniProtKB/TrEMBL
    Q6IAU3
    Related
    ENSP00000344609.6, ENST00000339775.10
    Conserved Domains (1) summary
    cl15439
    Location:1 → 104
    BTG; BTG family

  2. NM_006806.5 → NP_006797.3  protein BTG3 isoform b

    See identical proteins and their annotated locations for NP_006797.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK289408, BF110486, DA381239, DR155504
    Consensus CDS
    CCDS13569.1
    UniProtKB/Swiss-Prot
    D3DSC4, Q14201, Q53XV1, Q96ET7
    UniProtKB/TrEMBL
    Q6IAU3
    Related
    ENSP00000284879.8, ENST00000348354.7
    Conserved Domains (1) summary
    smart00099
    Location:1 → 108
    btg1; tob/btg1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    17593653..17612901 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440673.1 → XP_047296629.1  protein BTG3 isoform X4

  2. XM_011529441.2 → XP_011527743.1  protein BTG3 isoform X2

    Conserved Domains (1) summary
    cl15439
    Location:11 → 114
    BTG; BTG family

  3. XM_047440672.1 → XP_047296628.1  protein BTG3 isoform X3

  4. XM_047440670.1 → XP_047296626.1  protein BTG3 isoform X1

  5. XM_047440671.1 → XP_047296627.1  protein BTG3 isoform X3

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187627.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    448..9207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    15948673..15970578 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324322.1 → XP_054180297.1  protein BTG3 isoform X3

  2. XM_054324324.1 → XP_054180299.1  protein BTG3 isoform X4

  3. XM_054324321.1 → XP_054180296.1  protein BTG3 isoform X2

  4. XM_054324323.1 → XP_054180298.1  protein BTG3 isoform X3

  5. XM_054324320.1 → XP_054180295.1  protein BTG3 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14201.3 GenPept UniProtKB/Swiss-Prot:Q14201

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous