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Rnf20 ring finger protein 20 [ Mus musculus (house mouse) ]

Gene ID: 109331, updated on 11-Apr-2024

Summary

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Official Symbol
Rnf20provided by MGI
Official Full Name
ring finger protein 20provided by MGI
Primary source
MGI:MGI:1925927
See related
Ensembl:ENSMUSG00000028309 AllianceGenome:MGI:1925927
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA4116; 4833430L21Rik
Summary
Enables chromatin binding activity. Acts upstream of or within histone ubiquitination and positive regulation of histone methylation. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of HULC complex and ubiquitin ligase complex. Is expressed in several structures, including adrenal gland; central nervous system; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human RNF20 (ring finger protein 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 22.3), CNS E14 (RPKM 15.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 B1; 4 26.69 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (49632005..49656887)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (49632005..49656887)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10187 Neighboring gene STARR-positive B cell enhancer ABC_E2112 Neighboring gene predicted gene, 33159 Neighboring gene predicted gene, 45952 Neighboring gene glutamate receptor ionotropic, NMDA3A Neighboring gene protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) Neighboring gene STARR-seq mESC enhancer starr_10189 Neighboring gene STARR-seq mESC enhancer starr_10190 Neighboring gene predicted gene, 25485

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rnf20 deficiency in adipocyte impairs adipose tissue development and thermogenesis. Liang X, et al. Protein Cell, 2021 Jun. PMID 32797353, Free PMC Article
  2. H2B ubiquitination regulates meiotic recombination by promoting chromatin relaxation. Xu Z, et al. Nucleic Acids Res, 2016 Nov 16. PMID 27431324, Free PMC Article
  3. Involvement of histone H2B monoubiquitination in the regulation of mouse preimplantation development. Ooga M, et al. J Reprod Dev, 2015. PMID 25740253, Free PMC Article
  4. R-loops and genomic instability in Bre1 (RNF20/40)-deficient cells. Chernikova SB, et al. Cell Cycle, 2012 Aug 15. PMID 22825248, Free PMC Article
  5. RNF20/RNF40 ameliorates streptozotocin-induced type 1 diabetes by activating vitamin D receptors in vivo. Liu J, et al. Allergol Immunopathol (Madr), 2023. PMID 37422774

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Impact of Ring Finger Protein 20 and Its Downstream Regulation on Renal Tubular Injury in a Unilateral Nephrectomy Mouse Model Fed a High-Fat Diet.
    Title: Impact of Ring Finger Protein 20 and Its Downstream Regulation on Renal Tubular Injury in a Unilateral Nephrectomy Mouse Model Fed a High-Fat Diet.
  2. Epigenetic regulator RNF20 underlies temporal hierarchy of gene expression to regulate postnatal cardiomyocyte polarization.
    Title: Epigenetic regulator RNF20 underlies temporal hierarchy of gene expression to regulate postnatal cardiomyocyte polarization.
  3. Adipocyte Rnf20 ablation increases the fast-twitch fibers of skeletal muscle via lysophosphatidylcholine 16:0.
    Title: Adipocyte Rnf20 ablation increases the fast-twitch fibers of skeletal muscle via lysophosphatidylcholine 16:0.
  4. RNF20 deletion causes inflammation in model of sepsis through the NLRP3 activation.
    Title: RNF20 deletion causes inflammation in model of sepsis through the NLRP3 activation.
  5. RNF20/RNF40 ameliorates streptozotocin-induced type 1 diabetes by activating vitamin D receptors in vivo.
    Title: RNF20/RNF40 ameliorates streptozotocin-induced type 1 diabetes by activating vitamin D receptors in vivo.
  6. Endothelial cells regulated by RNF20 orchestrate the proliferation and differentiation of neural precursor cells during embryonic development.
    Title: Endothelial cells regulated by RNF20 orchestrate the proliferation and differentiation of neural precursor cells during embryonic development.
  7. Rnf20 deficiency in adipocyte impairs adipose tissue development and thermogenesis.
    Title: Rnf20 deficiency in adipocyte impairs adipose tissue development and thermogenesis.
  8. Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation.
    Title: Massively parallel in vivo CRISPR screening identifies RNF20/40 as epigenetic regulators of cardiomyocyte maturation.
  9. RNF20 promoted proteasomal degradation of nuclear corepressor 1 (NCoR1), which led to stimulation of the transcriptional activity of PPARgamma. Collectively, these data suggest that RNF20-NCoR1 is a novel axis in adipocyte biology through fine-tuning the transcriptional activity of PPARgamma.
    Title: RNF20 Functions as a Transcriptional Coactivator for PPARγ by Promoting NCoR1 Degradation in Adipocytes.
  10. These data suggest that Rnf20 functions at the Rfx3 locus regulating cilia motility and cardiac situs and identify H2Bub1 as an upstream transcriptional regulator controlling tissue-specific expression of cilia genes. Our findings mechanistically link the two functional gene ontologies that have been implicated in human CHD: chromatin remodeling and cilia function.
    Title: Histone H2B monoubiquitination regulates heart development via epigenetic control of cilia motility.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4116

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H2B C-terminal K residue ubiquitin ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H2B C-terminal K residue ubiquitin ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables p53 binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of HULC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of HULC complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase BRE1A
Names
BRE1-A
RING-type E3 ubiquitin transferase BRE1A
NP_001156735.1
NP_001343330.1
NP_892044.1
XP_006537616.1
XP_011248208.1
XP_030108941.1
XP_036019473.1
XP_036019474.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163263.1 → NP_001156735.1  E3 ubiquitin-protein ligase BRE1A isoform 1

    See identical proteins and their annotated locations for NP_001156735.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK051278, AK139883, BF730643, BQ442966, CJ052397, CN531555, DV660388
    Consensus CDS
    CCDS18178.1
    UniProtKB/Swiss-Prot
    A2AIR3, Q3UT10, Q3V350, Q5DTM8, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4
    Related
    ENSMUSP00000128546.2, ENSMUST00000167496.8
    Conserved Domains (3) summary
    PTZ00121
    Location:320 → 934
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:41 → 394
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16704
    Location:918 → 963
    RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins

  2. NM_001356401.1 → NP_001343330.1  E3 ubiquitin-protein ligase BRE1A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK053783, AK139883, AL732521, BF730643, BQ442966, CN531555, DV660388
    Conserved Domains (2) summary
    PTZ00121
    Location:75 → 689
    PTZ00121; MAEBL; Provisional
    cd16704
    Location:673 → 718
    RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins

  3. NM_182999.2 → NP_892044.1  E3 ubiquitin-protein ligase BRE1A isoform 1

    See identical proteins and their annotated locations for NP_892044.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK053783, AK139883, BF730643, BQ442966, CJ052397, CN531555, DV660388
    Consensus CDS
    CCDS18178.1
    UniProtKB/Swiss-Prot
    A2AIR3, Q3UT10, Q3V350, Q5DTM8, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4
    Related
    ENSMUSP00000029989.5, ENSMUST00000029989.11
    Conserved Domains (3) summary
    PTZ00121
    Location:320 → 934
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:41 → 394
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16704
    Location:918 → 963
    RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    49632005..49656887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537553.4 → XP_006537616.1  E3 ubiquitin-protein ligase BRE1A isoform X1

    See identical proteins and their annotated locations for XP_006537616.1

    UniProtKB/Swiss-Prot
    A2AIR3, Q3UT10, Q3V350, Q5DTM8, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4
    Conserved Domains (3) summary
    PTZ00121
    Location:320 → 934
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:41 → 394
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16704
    Location:918 → 963
    RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins

  2. XM_011249906.4 → XP_011248208.1  E3 ubiquitin-protein ligase BRE1A isoform X1

    See identical proteins and their annotated locations for XP_011248208.1

    UniProtKB/Swiss-Prot
    A2AIR3, Q3UT10, Q3V350, Q5DTM8, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4
    Conserved Domains (3) summary
    PTZ00121
    Location:320 → 934
    PTZ00121; MAEBL; Provisional
    COG1196
    Location:41 → 394
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd16704
    Location:918 → 963
    RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins

  3. XM_036163580.1 → XP_036019473.1  E3 ubiquitin-protein ligase BRE1A isoform X2

    Conserved Domains (2) summary
    PTZ00121
    Location:75 → 689
    PTZ00121; MAEBL; Provisional
    cd16704
    Location:673 → 718
    RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins

  4. XM_036163581.1 → XP_036019474.1  E3 ubiquitin-protein ligase BRE1A isoform X3

    Conserved Domains (2) summary
    PTZ00121
    Location:51 → 665
    PTZ00121; MAEBL; Provisional
    cd16704
    Location:649 → 694
    RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins

  5. XM_030253081.2 → XP_030108941.1  E3 ubiquitin-protein ligase BRE1A isoform X2

    Conserved Domains (2) summary
    PTZ00121
    Location:75 → 689
    PTZ00121; MAEBL; Provisional
    cd16704
    Location:673 → 718
    RING-HC_RNF20_like; RING finger, HC subclass, found in RING finger protein RNF20, RNF40, and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5DTM8.2 GenPept UniProtKB/Swiss-Prot:Q5DTM8

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