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C1qtnf7 C1q and tumor necrosis factor related protein 7 [ Mus musculus (house mouse) ]

Gene ID: 109323, updated on 5-Mar-2024

Summary

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Official Symbol
C1qtnf7provided by MGI
Official Full Name
C1q and tumor necrosis factor related protein 7provided by MGI
Primary source
MGI:MGI:1925911
See related
Ensembl:ENSMUSG00000061535 AllianceGenome:MGI:1925911
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adig; Ctrp7; 5530401N20Rik; 8430425G24Rik
Summary
Enables identical protein binding activity. Located in extracellular space. Is expressed in several structures, including adipose tissue; central nervous system; genitourinary system; gut; and skeleton. Orthologous to human C1QTNF7 (C1q and TNF related 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 5.7), lung adult (RPKM 3.9) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 B3; 5 23.78 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (43672792..43776805)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (43515425..43619126)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7854 Neighboring gene STARR-seq mESC enhancer starr_12968 Neighboring gene cytoplasmic polyadenylation element binding protein 2 Neighboring gene STARR-seq mESC enhancer starr_12969 Neighboring gene STARR-positive B cell enhancer mm9_chr5:43715638-43715939 Neighboring gene STARR-seq mESC enhancer starr_12970 Neighboring gene predicted gene 43699 Neighboring gene STARR-seq mESC enhancer starr_12971 Neighboring gene STARR-seq mESC enhancer starr_12973 Neighboring gene predicted gene 15866 Neighboring gene predicted gene, 35762 Neighboring gene coiled-coil and C2 domain containing 2A Neighboring gene F-box and leucine-rich repeat protein 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CTRP7 deletion attenuates obesity-linked glucose intolerance, adipose tissue inflammation, and hepatic stress. Petersen PS, et al. Am J Physiol Endocrinol Metab, 2017 Apr 1. PMID 28223291, Free PMC Article
  2. Expression of adipokines in preimplantation rabbit and mice embryos. Schmidt T, et al. Histochem Cell Biol, 2008 Jun. PMID 18330590
  3. A family of Acrp30/adiponectin structural and functional paralogs. Wong GW, et al. Proc Natl Acad Sci U S A, 2004 Jul 13. PMID 15231994, Free PMC Article
  4. Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions. Wong GW, et al. Biochem J, 2008 Dec 1. PMID 18783346, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
complement C1q tumor necrosis factor-related protein 7
Names
C1q and tumor necrosis factor related protein 5
adiponectin g

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135172.1 → NP_001128644.1  complement C1q tumor necrosis factor-related protein 7 isoform a precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK017441, BC038308, BC090967
    Consensus CDS
    CCDS51488.1
    UniProtKB/TrEMBL
    A0A3B0J1T4, E9PVG1
    Related
    ENSMUSP00000076206.8, ENSMUST00000076939.10
    Conserved Domains (2) summary
    pfam01391
    Location:63 → 115
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:156 → 280
    C1q; C1q domain

  2. NM_175425.4 → NP_780634.2  complement C1q tumor necrosis factor-related protein 7 isoform b precursor

    See identical proteins and their annotated locations for NP_780634.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream translation initiation codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    BC038308, BC090967
    Consensus CDS
    CCDS19262.1
    UniProtKB/Swiss-Prot
    Q8BVD7, Q8CHX9
    UniProtKB/TrEMBL
    A0A3B0J1T4, Q5BKS0
    Related
    ENSMUSP00000113520.2, ENSMUST00000121872.3
    Conserved Domains (2) summary
    pfam01391
    Location:56 → 108
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:149 → 273
    C1q; C1q domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    43672792..43776805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503665.5 → XP_006503728.1  complement C1q tumor necrosis factor-related protein 7 isoform X1

    See identical proteins and their annotated locations for XP_006503728.1

    UniProtKB/Swiss-Prot
    Q8BVD7, Q8CHX9
    UniProtKB/TrEMBL
    A0A3B0J1T4, Q5BKS0
    Conserved Domains (2) summary
    pfam01391
    Location:56 → 108
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:149 → 273
    C1q; C1q domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BVD7.2 GenPept UniProtKB/Swiss-Prot:Q8BVD7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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