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Prex2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 [ Mus musculus (house mouse) ]

Gene ID: 109294, updated on 21-Apr-2024

Summary

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Official Symbol
Prex2provided by MGI
Official Full Name
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2provided by MGI
Primary source
MGI:MGI:1923385
See related
Ensembl:ENSMUSG00000048960 AllianceGenome:MGI:1923385
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Depdc2; P-Rex2; D430013K02; 6230420N16Rik; C030045D06Rik
Summary
Predicted to enable GTPase activator activity and guanyl-nucleotide exchange factor activity. Acts upstream of or within adult locomotory behavior; dendrite morphogenesis; and phosphatidylinositol 3-kinase signaling. Located in plasma membrane. Is expressed in brain ventricular layer and gut. Human ortholog(s) of this gene implicated in Klatskin's tumor. Orthologous to human PREX2 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 9.2), bladder adult (RPKM 4.1) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 A2; 1 2.57 cM
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (11063496..11373907)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (10993273..11303683)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00189 Neighboring gene STARR-seq mESC enhancer starr_00190 Neighboring gene STARR-seq mESC enhancer starr_00191 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 14 pseudogene Neighboring gene predicted gene 28659 Neighboring gene STARR-seq mESC enhancer starr_00193 Neighboring gene STARR-seq mESC enhancer starr_00195 Neighboring gene predicted gene, 24173 Neighboring gene STARR-seq mESC enhancer starr_00196 Neighboring gene STARR-seq mESC enhancer starr_00198 Neighboring gene STARR-seq mESC enhancer starr_00199 Neighboring gene STARR-seq mESC enhancer starr_00200 Neighboring gene RIKEN cDNA A830018L16 gene Neighboring gene STARR-seq mESC enhancer starr_00202 Neighboring gene STARR-seq mESC enhancer starr_00204 Neighboring gene STARR-seq mESC enhancer starr_00208 Neighboring gene STARR-seq mESC enhancer starr_00209 Neighboring gene STARR-seq mESC enhancer starr_00210 Neighboring gene STARR-seq mESC enhancer starr_00211 Neighboring gene STARR-seq mESC enhancer starr_00212 Neighboring gene predicted gene, 30898

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. P-Rex2 mediation of synaptic plasticity contributes to bone cancer pain. Fu Q, et al. Mol Pain, 2022 Jan-Dec. PMID 35083941, Free PMC Article
  2. P-Rex2, a Rac-guanine nucleotide exchange factor, is expressed selectively in ribbon synaptic terminals of the mouse retina. Sherry DM, et al. BMC Neurosci, 2013 Jul 11. PMID 23844743, Free PMC Article
  3. Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase. Jackson C, et al. PLoS One, 2010 Aug 4. PMID 20694145, Free PMC Article
  4. Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma. Lissanu Deribe Y, et al. Proc Natl Acad Sci U S A, 2016 Mar 1. PMID 26884185, Free PMC Article
  5. P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination. Donald S, et al. Proc Natl Acad Sci U S A, 2008 Mar 18. PMID 18334636, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. P-Rex2 mediation of synaptic plasticity contributes to bone cancer pain.
    Title: P-Rex2 mediation of synaptic plasticity contributes to bone cancer pain.
  2. complex signaling mechanisms that involve PREX2, PI3K/AKT/PTEN and downstream epigenetic machinery to deregulate expression of key cell cycle regulators
    Title: Interplay between PREX2 mutations and the PI3K pathway and its effect on epigenetic regulation of gene expression in NRAS-mutant melanoma.
  3. P-REX2 PH-domain-mediated inhibition of PTEN has a role in regulating insulin sensitivity and glucose homeostasis
    Title: Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis.
  4. This study demonistrated that the P-Rex2, a GEF that specifically activates Rac small GTPases, is expressed in a cell- and synapse-specific manner in the retina.
    Title: P-Rex2, a Rac-guanine nucleotide exchange factor, is expressed selectively in ribbon synaptic terminals of the mouse retina.
  5. PI3K/P-Rex/Rac pathway is required for late phase long-term potentiation in the mouse cerebellum
    Title: Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase.
  6. P-Rex1 and P-Rex2 are important regulators of Purkinje cell morphology and cerebellar function
    Title: P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein
Names
DEP domain containing 2
DEP domain-containing protein 2
ptdIns(3,4,5)-dependent Rac exchanger 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033636.4 → NP_001028808.1  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform 2

    See identical proteins and their annotated locations for NP_001028808.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 5' UTR and lacks much of the 5' coding region when compared to variant 1. The resulting protein (isoform 2) is much shorter when it is compared to isoform 1.
    Source sequence(s)
    AC164600, AI553603, AK136059
    UniProtKB/TrEMBL
    Q3UWW3

  2. NM_029525.1 → NP_083801.1  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform 1

    See identical proteins and their annotated locations for NP_083801.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer variant and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AC102481, AC102631, AC164600, AI553603, AK138884
    Consensus CDS
    CCDS48217.1
    UniProtKB/Swiss-Prot
    E9QMG3, Q3LAC4, Q3UQI2, Q3UU18, Q9CXD5
    Related
    ENSMUSP00000027056.6, ENSMUST00000027056.12
    Conserved Domains (6) summary
    cd00992
    Location:669 → 736
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04439
    Location:374 → 454
    DEP_1_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
    cd04440
    Location:466 → 558
    DEP_2_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
    cd01224
    Location:210 → 356
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    pfam00621
    Location:19 → 204
    RhoGEF; RhoGEF domain
    pfam17820
    Location:607 → 660
    PDZ_6; PDZ domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    11063496..11373907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495441.5 → XP_006495504.1  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform X1

    Conserved Domains (5) summary
    cd00992
    Location:669 → 736
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04439
    Location:374 → 454
    DEP_1_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
    cd04440
    Location:466 → 558
    DEP_2_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
    cd01224
    Location:210 → 356
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    pfam00621
    Location:19 → 204
    RhoGEF; RhoGEF domain

  2. XM_036153084.1 → XP_036008977.1  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform X3

    Conserved Domains (6) summary
    cd00992
    Location:669 → 736
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04439
    Location:374 → 454
    DEP_1_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
    cd04440
    Location:466 → 558
    DEP_2_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
    cd01224
    Location:210 → 356
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    pfam00621
    Location:19 → 204
    RhoGEF; RhoGEF domain
    pfam17820
    Location:607 → 660
    PDZ_6; PDZ domain

  3. XM_036153075.1 → XP_036008968.1  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform X2

    Conserved Domains (5) summary
    cd00992
    Location:480 → 547
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04439
    Location:185 → 265
    DEP_1_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
    cd04440
    Location:277 → 369
    DEP_2_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
    cd01224
    Location:21 → 167
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    pfam17820
    Location:418 → 471
    PDZ_6; PDZ domain

RNA

  1. XR_004934097.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3LAC4.2 GenPept UniProtKB/Swiss-Prot:Q3LAC4

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