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Me3 malic enzyme 3, NADP(+)-dependent, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 109264, updated on 11-Apr-2024

Summary

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Official Symbol
Me3provided by MGI
Official Full Name
malic enzyme 3, NADP(+)-dependent, mitochondrialprovided by MGI
Primary source
MGI:MGI:1916679
See related
Ensembl:ENSMUSG00000030621 AllianceGenome:MGI:1916679
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700020C08Rik; B230207H15Rik
Summary
Predicted to enable NADP+ binding activity and malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in malate metabolic process and pyruvate metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; integumental system; metanephros; and sensory organ. Orthologous to human ME3 (malic enzyme 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 5.3), frontal lobe adult (RPKM 4.9) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 D3; 7 50.27 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (89281492..89503423)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (89632284..89854359)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene serine protease 23 Neighboring gene STARR-seq mESC enhancer starr_19491 Neighboring gene STARR-seq mESC enhancer starr_19492 Neighboring gene STARR-seq mESC enhancer starr_19493 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 53381 Neighboring gene STARR-seq mESC enhancer starr_19494 Neighboring gene predicted gene 15744 Neighboring gene STARR-seq mESC enhancer starr_19496 Neighboring gene coiled-coil domain containing 81 Neighboring gene STARR-positive B cell enhancer ABC_E2241 Neighboring gene heat shock protein nuclear import factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and properties of the nicotinamide adenine dinucleotide (phosphate)+-dependent malic enzyme in mouse ascites tumor mitochondria. Sauer LA, et al. Cancer Res, 1978 Jun. PMID 25711
  2. Atlas of gene expression in the developing kidney at microanatomic resolution. Brunskill EW, et al. Dev Cell, 2008 Nov. PMID 19000842, Free PMC Article
  3. Characterization of the zinc-induced Shank3 interactome of mouse synaptosome. Lee Y, et al. Biochem Biophys Res Commun, 2017 Dec 16. PMID 29111324
  4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC107389

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NADP+ binding ISO
Inferred from Sequence Orthology
more info
  
enables malate dehydrogenase (decarboxylating) (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables malate dehydrogenase (decarboxylating) (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables malate dehydrogenase (decarboxylating) (NADP+) activity ISO
Inferred from Sequence Orthology
more info
  
enables malic enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxaloacetate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in malate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in malate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in pyruvate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyruvate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pyruvate metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NADP-dependent malic enzyme, mitochondrial
Names
NADP-ME
NP_852072.2
XP_006507252.1
XP_006507253.1
XP_006507255.1
XP_006507257.1
XP_017177416.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181407.5 → NP_852072.2  NADP-dependent malic enzyme, mitochondrial

    See identical proteins and their annotated locations for NP_852072.2

    Status: VALIDATED

    Source sequence(s)
    AC164643, AC165077
    Consensus CDS
    CCDS21443.1
    UniProtKB/Swiss-Prot
    Q499F4, Q8BMF3
    Related
    ENSMUSP00000032856.7, ENSMUST00000032856.13
    Conserved Domains (1) summary
    PLN03129
    Location:9 → 587
    PLN03129; NADP-dependent malic enzyme; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    89281492..89503423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507189.4 → XP_006507252.1  NADP-dependent malic enzyme, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006507252.1

    UniProtKB/Swiss-Prot
    Q499F4, Q8BMF3
    Conserved Domains (1) summary
    PLN03129
    Location:9 → 587
    PLN03129; NADP-dependent malic enzyme; Provisional

  2. XM_017321927.2 → XP_017177416.1  NADP-dependent malic enzyme, mitochondrial isoform X3

    Conserved Domains (1) summary
    PLN03129
    Location:9 → 267
    PLN03129; NADP-dependent malic enzyme; Provisional

  3. XM_006507190.5 → XP_006507253.1  NADP-dependent malic enzyme, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006507253.1

    UniProtKB/Swiss-Prot
    Q499F4, Q8BMF3
    Conserved Domains (1) summary
    PLN03129
    Location:9 → 587
    PLN03129; NADP-dependent malic enzyme; Provisional

  4. XM_006507194.5 → XP_006507257.1  NADP-dependent malic enzyme, mitochondrial isoform X4

    Conserved Domains (1) summary
    PLN03129
    Location:2 → 318
    PLN03129; NADP-dependent malic enzyme; Provisional

  5. XM_006507192.5 → XP_006507255.1  NADP-dependent malic enzyme, mitochondrial isoform X2

    Conserved Domains (1) summary
    PLN03129
    Location:34 → 354
    PLN03129; NADP-dependent malic enzyme; Provisional

RNA

  1. XR_003946371.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BMF3.2 GenPept UniProtKB/Swiss-Prot:Q8BMF3

Gene LinkOut

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