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Adtrp androgen dependent TFPI regulating protein [ Mus musculus (house mouse) ]

Gene ID: 109254, updated on 5-Mar-2024

Summary

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Official Symbol
Adtrpprovided by MGI
Official Full Name
androgen dependent TFPI regulating proteinprovided by MGI
Primary source
MGI:MGI:1924596
See related
Ensembl:ENSMUSG00000058022 AllianceGenome:MGI:1924596
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9530008L14Rik
Summary
Predicted to enable hydrolase activity. Predicted to be involved in several processes, including cell migration involved in sprouting angiogenesis; negative regulation of secretion by cell; and positive regulation of macromolecule metabolic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in caveola and cell surface. Predicted to be active in endomembrane system. Orthologous to human ADTRP (androgen dependent TFPI regulating protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 17.6), kidney adult (RPKM 12.1) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Adtrp in Genome Data Viewer
Location:
13 A4; 13 20.61 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (41916621..42001092, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (41763145..41847616, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5082 Neighboring gene predicted gene, 40925 Neighboring gene STARR-seq mESC enhancer starr_34305 Neighboring gene STARR-seq mESC enhancer starr_34306 Neighboring gene STARR-positive B cell enhancer ABC_E7230 Neighboring gene STARR-seq mESC enhancer starr_34308 Neighboring gene STARR-positive B cell enhancer mm9_chr13:41978984-41979285 Neighboring gene predicted gene 10790 Neighboring gene STARR-positive B cell enhancer ABC_E9397 Neighboring gene predicted gene, 22157 Neighboring gene predicted gene, 32555

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Adtrp regulates thermogenic activity of adipose tissue via mediating the secretion of S100b. Li P, et al. Cell Mol Life Sci, 2022 Jul 8. PMID 35804197
  2. Hepatic ADTRP overexpression does not influence lipid and glucose metabolism. Defour M, et al. Am J Physiol Cell Physiol, 2021 Oct 1. PMID 34288722
  3. AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice. Erikci Ertunc M, et al. J Biol Chem, 2020 May 1. PMID 32152231, Free PMC Article
  4. Role of ADTRP (Androgen-Dependent Tissue Factor Pathway Inhibitor Regulating Protein) in Vascular Development and Function. Patel MM, et al. J Am Heart Assoc, 2018 Nov 20. PMID 30571485, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Adtrp regulates thermogenic activity of adipose tissue via mediating the secretion of S100b.
    Title: Adtrp regulates thermogenic activity of adipose tissue via mediating the secretion of S100b.
  2. Hepatic ADTRP overexpression does not influence lipid and glucose metabolism.
    Title: Hepatic ADTRP overexpression does not influence lipid and glucose metabolism.
  3. AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice.
    Title: AIG1 and ADTRP are endogenous hydrolases of fatty acid esters of hydroxy fatty acids (FAHFAs) in mice.
  4. role in vascular development and function
    Title: Role of ADTRP (Androgen-Dependent Tissue Factor Pathway Inhibitor Regulating Protein) in Vascular Development and Function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to oxidised low-density lipoprotein particle stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of extracellular matrix constituent secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of leukocyte migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of lymphocyte migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in caveola ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
androgen-dependent TFPI-regulating protein
Names
FAHFA hydrolase ADTRP
androgen-dependent TPF1-regulating protein
fatty acid esters of hydroxy fatty acids hydrolase ADTRP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145875.1 → NP_001139347.1  androgen-dependent TFPI-regulating protein isoform 2

    See identical proteins and their annotated locations for NP_001139347.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AC165263, AK135327, BY719442
    Consensus CDS
    CCDS49250.1
    UniProtKB/Swiss-Prot
    D3Z6U0, Q3UXS3, Q8C138, Q8K180
    Related
    ENSMUSP00000113661.2, ENSMUST00000121404.8
    Conserved Domains (1) summary
    pfam04750
    Location:5 → 216
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  2. NM_175417.4 → NP_780626.1  androgen-dependent TFPI-regulating protein isoform 1

    See identical proteins and their annotated locations for NP_780626.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AC165263, AK029025
    Consensus CDS
    CCDS36642.1
    UniProtKB/TrEMBL
    A0A0R4J0W3
    Related
    ENSMUSP00000071899.4, ENSMUST00000072012.10
    Conserved Domains (1) summary
    pfam04750
    Location:37 → 248
    Far-17a_AIG1; FAR-17a/AIG1-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    41916621..42001092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247126.1 → XP_030102986.1  androgen-dependent TFPI-regulating protein isoform X2

    UniProtKB/Swiss-Prot
    D3Z6U0, Q3UXS3, Q8C138, Q8K180
    Conserved Domains (1) summary
    pfam04750
    Location:5 → 216
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  2. XM_006516835.2 → XP_006516898.1  androgen-dependent TFPI-regulating protein isoform X1

    Conserved Domains (1) summary
    pfam04750
    Location:37 → 248
    Far-17a_AIG1; FAR-17a/AIG1-like protein

  3. XM_011244369.2 → XP_011242671.1  androgen-dependent TFPI-regulating protein isoform X3

    Conserved Domains (1) summary
    pfam04750
    Location:37 → 162
    Far-17a_AIG1; FAR-17a/AIG1-like protein

RNA

  1. XR_003950421.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C138.2 GenPept UniProtKB/Swiss-Prot:Q8C138

Gene LinkOut

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