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Tspan9 tetraspanin 9 [ Mus musculus (house mouse) ]

Gene ID: 109246, updated on 11-Apr-2024

Summary

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Official Symbol
Tspan9provided by MGI
Official Full Name
tetraspanin 9provided by MGI
Primary source
MGI:MGI:1924558
See related
Ensembl:ENSMUSG00000030352 AllianceGenome:MGI:1924558
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tspan-9; 6720474K14Rik; 9430079M16Rik
Summary
Located in membrane. Is expressed in several structures, including central nervous system; diaphragm; gut; limb segment; and skeletal musculature. Orthologous to human TSPAN9 (tetraspanin 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 33.3), cerebellum adult (RPKM 22.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 F3; 6 62.73 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (127938359..128120541, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (127961396..128143578, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38901 Neighboring gene predicted gene, 40401 Neighboring gene tetraspanin 11 Neighboring gene STARR-seq mESC enhancer starr_17424 Neighboring gene predicted gene, 38903 Neighboring gene predicted gene 15870 Neighboring gene predicted gene, 53341 Neighboring gene predicted gene, 34416 Neighboring gene predicted gene, 52879 Neighboring gene STARR-seq mESC enhancer starr_17429 Neighboring gene RIKEN cDNA 9330102E08 gene Neighboring gene Rho GTPase activating protein 20 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional relevance of tetraspanin CD9 in vascular smooth muscle cell injury phenotypes: a novel target for the prevention of neointimal hyperplasia. Kotha J, et al. Atherosclerosis, 2009 Apr. PMID 18799160
  2. Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains. Protty MB, et al. Biochem J, 2009 Jan 1. PMID 18795891, Free PMC Article
  3. Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation. Haining EJ, et al. Platelets, 2017 Nov. PMID 28032533, Free PMC Article
  4. Mitocytosis, a migrasome-mediated mitochondrial quality-control process. Jiao H, et al. Cell, 2021 May 27. PMID 34048705
  5. Appearance of new tetraspanin genes during vertebrate evolution. Garcia-España A, et al. Genomics, 2008 Apr. PMID 18291621

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation.
    Title: Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation.
  2. tetraspanin CD9 has a role in determining vascular smooth muscle cell injury phenotypes
    Title: Functional relevance of tetraspanin CD9 in vascular smooth muscle cell injury phenotypes: a novel target for the prevention of neointimal hyperplasia.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (3) 
  • Endonuclease-mediated (5)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within collagen-activated tyrosine kinase receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mitocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within mitocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neutrophil homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within platelet aggregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within receptor diffusion trapping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of mitochondrial membrane potential IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in migrasome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in tetraspanin-enriched microdomain ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tetraspanin-9
Names
tetraspan NET-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356301.2 → NP_001343230.1  tetraspanin-9 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variants 1 and 3-5, encodes isoform b.
    Source sequence(s)
    AC135355, AC144778
    Consensus CDS
    CCDS20568.1
    UniProtKB/Swiss-Prot
    Q3TQQ0, Q8BJU2
    Related
    ENSMUSP00000107796.2, ENSMUST00000112173.8
    Conserved Domains (2) summary
    cd03165
    Location:105 → 202
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:9 → 226
    Tetraspannin; Tetraspanin family

  2. NM_001379133.1 → NP_001366062.1  tetraspanin-9 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 1, 2, 4, and 5, encodes isoform b.
    Source sequence(s)
    AC135355, AC144778
    UniProtKB/Swiss-Prot
    Q3TQQ0, Q8BJU2
    Conserved Domains (2) summary
    cd03165
    Location:105 → 202
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:9 → 226
    Tetraspannin; Tetraspanin family

  3. NM_001379134.1 → NP_001366063.1  tetraspanin-9 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 1-3 and 5, encodes isoform b.
    Source sequence(s)
    AC135355, AC144778
    UniProtKB/Swiss-Prot
    Q3TQQ0, Q8BJU2
    Conserved Domains (2) summary
    cd03165
    Location:105 → 202
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:9 → 226
    Tetraspannin; Tetraspanin family

  4. NM_001379135.1 → NP_001366064.1  tetraspanin-9 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 1-4, encodes isoform b.
    Source sequence(s)
    AC135355, AC144778
    UniProtKB/Swiss-Prot
    Q3TQQ0, Q8BJU2
    Conserved Domains (2) summary
    cd03165
    Location:105 → 202
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:9 → 226
    Tetraspannin; Tetraspanin family

  5. NM_001379136.1 → NP_001366065.1  tetraspanin-9 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC135355
    Conserved Domains (2) summary
    cd03165
    Location:196 → 293
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:100 → 317
    Tetraspannin; Tetraspanin family

  6. NM_175414.6 → NP_780623.1  tetraspanin-9 isoform b

    See identical proteins and their annotated locations for NP_780623.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variants 2-5, encodes isoform b.
    Source sequence(s)
    AC135355, AC144778
    Consensus CDS
    CCDS20568.1
    UniProtKB/Swiss-Prot
    Q3TQQ0, Q8BJU2
    Related
    ENSMUSP00000032503.6, ENSMUST00000032503.12
    Conserved Domains (2) summary
    cd03165
    Location:105 → 202
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:9 → 226
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    127938359..128120541 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255085.1 → XP_030110945.1  tetraspanin-9 isoform X1

    Conserved Domains (2) summary
    cd03165
    Location:142 → 239
    NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
    pfam00335
    Location:46 → 263
    Tetraspannin; Tetraspanin family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BJU2.1 GenPept UniProtKB/Swiss-Prot:Q8BJU2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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