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Sccpdh saccharopine dehydrogenase (putative) [ Mus musculus (house mouse) ]

Gene ID: 109232, updated on 30-Apr-2024

Summary

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Official Symbol
Sccpdhprovided by MGI
Official Full Name
saccharopine dehydrogenase (putative)provided by MGI
Primary source
MGI:MGI:1924486
See related
Ensembl:ENSMUSG00000038936 AllianceGenome:MGI:1924486
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C330023F11Rik
Summary
Predicted to enable oxidoreductase activity. Predicted to be involved in glycolipid biosynthetic process. Located in mitochondrion. Is expressed in brain. Orthologous to human SCCPDH (saccharopine dehydrogenase (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 84.7), cerebellum adult (RPKM 29.1) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H4; 1 83.62 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (179495796..179514754)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (179667749..179687189)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2590 Neighboring gene STARR-positive B cell enhancer ABC_E4399 Neighboring gene transcription factor B2, mitochondrial Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:181508880-181509063 Neighboring gene consortin, connexin sorting protein Neighboring gene STARR-seq mESC enhancer starr_03181 Neighboring gene STARR-seq mESC enhancer starr_03183 Neighboring gene kinesin family member 28 Neighboring gene AT hook containing transcription factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E3340 Neighboring gene STARR-positive B cell enhancer ABC_E5865 Neighboring gene STARR-seq mESC enhancer starr_03185 Neighboring gene predicted gene, 31668 Neighboring gene STARR-seq mESC enhancer starr_03186

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
  2. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
  3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  4. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
saccharopine dehydrogenase-like oxidoreductase
Names
probable saccharopine dehydrogenase
NP_001404405.1
NP_001404406.1
NP_848768.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417476.1 → NP_001404405.1  saccharopine dehydrogenase-like oxidoreductase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113977

  2. NM_001417477.1 → NP_001404406.1  saccharopine dehydrogenase-like oxidoreductase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113977

  3. NM_178653.4 → NP_848768.1  saccharopine dehydrogenase-like oxidoreductase isforom 1

    See identical proteins and their annotated locations for NP_848768.1

    Status: VALIDATED

    Source sequence(s)
    AC113977
    Consensus CDS
    CCDS15563.1
    UniProtKB/Swiss-Prot
    Q3TMB9, Q8R127
    Related
    ENSMUSP00000040956.4, ENSMUST00000040538.10
    Conserved Domains (2) summary
    COG3268
    Location:1 → 421
    COG3268; Uncharacterized conserved protein, related to short-chain dehydrogenases [Function unknown]
    pfam03435
    Location:10 → 149
    Sacchrp_dh_NADP; Saccharopine dehydrogenase NADP binding domain

RNA

  1. NR_184455.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113977
    Related
    ENSMUST00000134287.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    179495796..179514754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R127.1 GenPept UniProtKB/Swiss-Prot:Q8R127

Gene LinkOut

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