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Fam118b family with sequence similarity 118, member B [ Mus musculus (house mouse) ]

Gene ID: 109229, updated on 5-Mar-2024

Summary

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Official Symbol
Fam118bprovided by MGI
Official Full Name
family with sequence similarity 118, member Bprovided by MGI
Primary source
MGI:MGI:1924483
See related
Ensembl:ENSMUSG00000050471 AllianceGenome:MGI:1924483
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ppp4r1l; 2310022O21Rik; 2700018L24Rik; C030004A17Rik
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in Cajal body organization. Predicted to be located in nucleus. Is expressed in central nervous system. Orthologous to human FAM118B (family with sequence similarity 118 member B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 21.9), thymus adult (RPKM 13.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A4; 9 20.12 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (35128261..35179172, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (35216965..35267875, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene toll-interleukin 1 receptor (TIR) domain-containing adaptor protein Neighboring gene predicted gene, 39318 Neighboring gene STARR-positive B cell enhancer ABC_E6723 Neighboring gene STARR-positive B cell enhancer ABC_E5059 Neighboring gene FAD-dependent oxidoreductase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_23764 Neighboring gene signal recognition particle receptor alpha Neighboring gene STARR-seq mESC enhancer starr_23765 Neighboring gene STARR-positive B cell enhancer ABC_E3823 Neighboring gene RNA pseudouridylate synthase domain containing 4 Neighboring gene RIKEN cDNA 4933422A05 gene Neighboring gene ribosomal protein L36 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein FAM118B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286604.1 → NP_001273533.1  protein FAM118B isoform 1

    See identical proteins and their annotated locations for NP_001273533.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 3 encode the same protein.
    Source sequence(s)
    AC160116, AK079397, AK081206
    Consensus CDS
    CCDS22961.1
    UniProtKB/Swiss-Prot
    Q3THR7, Q8BNN4, Q8BT26, Q8C569
    Related
    ENSMUSP00000113537.2, ENSMUST00000121564.8
    Conserved Domains (1) summary
    pfam13289
    Location:158 → 301
    SIR2_2; SIR2-like domain

  2. NM_175411.5 → NP_780620.1  protein FAM118B isoform 2

    See identical proteins and their annotated locations for NP_780620.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region, compared to variant 3. It encodes isoform 2, which is shorter, compared to isoform 1.
    Source sequence(s)
    AC160116, AK079397, AK081206
    Consensus CDS
    CCDS22960.1
    UniProtKB/Swiss-Prot
    Q8C569
    Related
    ENSMUSP00000066281.6, ENSMUST00000063782.12
    Conserved Domains (1) summary
    pfam13289
    Location:117 → 225
    SIR2_2; SIR2-like domain

  3. NM_194257.2 → NP_919233.1  protein FAM118B isoform 1

    See identical proteins and their annotated locations for NP_919233.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 3. Variants 1 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AC160116, AK079397, AK081206
    Consensus CDS
    CCDS22961.1
    UniProtKB/Swiss-Prot
    Q3THR7, Q8BNN4, Q8BT26, Q8C569
    Related
    ENSMUSP00000058377.8, ENSMUST00000059057.14
    Conserved Domains (1) summary
    pfam13289
    Location:158 → 301
    SIR2_2; SIR2-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    35128261..35179172 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244005.2 → XP_030099865.1  protein FAM118B isoform X3

    Conserved Domains (1) summary
    pfam13289
    Location:79 → 225
    SIR2_2; SIR2-like domain

  2. XM_006509938.4 → XP_006510001.1  protein FAM118B isoform X2

    Conserved Domains (1) summary
    pfam13289
    Location:158 → 301
    SIR2_2; SIR2-like domain

  3. XM_036154557.1 → XP_036010450.1  protein FAM118B isoform X2

    Conserved Domains (1) summary
    pfam13289
    Location:158 → 301
    SIR2_2; SIR2-like domain

  4. XM_030244004.2 → XP_030099864.1  protein FAM118B isoform X2

    Conserved Domains (1) summary
    pfam13289
    Location:158 → 301
    SIR2_2; SIR2-like domain

  5. XM_011242382.4 → XP_011240684.1  protein FAM118B isoform X1

    See identical proteins and their annotated locations for XP_011240684.1

    UniProtKB/Swiss-Prot
    Q3THR7, Q8BNN4, Q8BT26, Q8C569
    Conserved Domains (1) summary
    pfam13289
    Location:158 → 301
    SIR2_2; SIR2-like domain

  6. XM_036154556.1 → XP_036010449.1  protein FAM118B isoform X1

    UniProtKB/Swiss-Prot
    Q3THR7, Q8BNN4, Q8BT26, Q8C569
    Conserved Domains (1) summary
    pfam13289
    Location:158 → 301
    SIR2_2; SIR2-like domain

  7. XM_006509937.5 → XP_006510000.1  protein FAM118B isoform X1

    See identical proteins and their annotated locations for XP_006510000.1

    UniProtKB/Swiss-Prot
    Q3THR7, Q8BNN4, Q8BT26, Q8C569
    Conserved Domains (1) summary
    pfam13289
    Location:158 → 301
    SIR2_2; SIR2-like domain

  8. XM_030244006.2 → XP_030099866.1  protein FAM118B isoform X5

    Conserved Domains (1) summary
    pfam13289
    Location:21 → 164
    SIR2_2; SIR2-like domain

  9. XM_006509940.5 → XP_006510003.1  protein FAM118B isoform X4

    Conserved Domains (1) summary
    pfam13289
    Location:21 → 164
    SIR2_2; SIR2-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C569.1 GenPept UniProtKB/Swiss-Prot:Q8C569

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