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Atl3 atlastin GTPase 3 [ Mus musculus (house mouse) ]

Gene ID: 109168, updated on 30-Apr-2024

Summary

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Official Symbol
Atl3provided by MGI
Official Full Name
atlastin GTPase 3provided by MGI
Primary source
MGI:MGI:1924270
See related
Ensembl:ENSMUSG00000024759 AllianceGenome:MGI:1924270
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4633402C03Rik; 5730596K20Rik
Summary
Predicted to enable GTP binding activity; GTPase activity; and identical protein binding activity. Predicted to be involved in several processes, including Golgi organization; positive regulation of endoplasmic reticulum tubular network organization; and protein homooligomerization. Predicted to be located in endoplasmic reticulum tubular network membrane. Predicted to be integral component of membrane. Is expressed in olfactory cortex ventricular layer; orbito-sphenoid; and telencephalon ventricular layer. Human ortholog(s) of this gene implicated in hereditary sensory neuropathy type 1F. Orthologous to human ATL3 (atlastin GTPase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 31.9), bladder adult (RPKM 16.2) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 5.32 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (7471178..7515974)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (7494015..7538609)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene microRNA 6991 Neighboring gene zinc finger translocation associated Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7520209-7520392 Neighboring gene reticulon 3 Neighboring gene phospholipase A and acyltransferase 3 Neighboring gene STARR-seq mESC enhancer starr_45469 Neighboring gene STARR-seq mESC enhancer starr_45470 Neighboring gene lectin, galactose binding, soluble 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Disease-causing mutated ATLASTIN 3 is excluded from distal axons and reduces axonal autophagy. Behrendt L, et al. Neurobiol Dis, 2021 Jul. PMID 34019998
  2. Mammalian knock out cells reveal prominent roles for atlastin GTPases in ER network morphology. Zhao G, et al. Exp Cell Res, 2016 Nov 15. PMID 27669642
  3. REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects. Lee SH, et al. Nat Commun, 2020 Feb 19. PMID 32075961, Free PMC Article
  4. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Disease-causing mutated ATLASTIN 3 is excluded from distal axons and reduces axonal autophagy.
    Title: Disease-causing mutated ATLASTIN 3 is excluded from distal axons and reduces axonal autophagy.
  2. Endoplasmic reticulum morphology is markedly disrupted in ATL1, ATL2, and ATL3 knockout cells.
    Title: Mammalian knock out cells reveal prominent roles for atlastin GTPases in ER network morphology.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC28761

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum organization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endoplasmic reticulum tubular network organization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum tubular network ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum tubular network membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
atlastin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163505.1 → NP_001156977.1  atlastin-3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AC163276, AK077752, AK085735, AK147720, BP759756
    Consensus CDS
    CCDS50379.1
    UniProtKB/TrEMBL
    E9PYT3
    Related
    ENSMUSP00000132619.2, ENSMUST00000170373.9
    Conserved Domains (2) summary
    cl20817
    Location:378 → 427
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21455
    Location:32 → 300
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_146091.4 → NP_666203.3  atlastin-3 isoform 2

    See identical proteins and their annotated locations for NP_666203.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AC163276, AK077752, AK085735, AK147720, BP759756, BY108453, CA318221
    Consensus CDS
    CCDS29527.1
    UniProtKB/Swiss-Prot
    Q3UGW3, Q8C0L7, Q8C174, Q91YH5, Q99LZ9
    Related
    ENSMUSP00000025668.8, ENSMUST00000025668.9
    Conserved Domains (2) summary
    cl20817
    Location:383 → 432
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21455
    Location:37 → 305
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    7471178..7515974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526604.5 → XP_006526667.1  atlastin-3 isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:48 → 316
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91YH5.1 GenPept UniProtKB/Swiss-Prot:Q91YH5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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