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Ube2q2 ubiquitin-conjugating enzyme E2Q family member 2 [ Mus musculus (house mouse) ]

Gene ID: 109161, updated on 5-Mar-2024

Summary

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Official Symbol
Ube2q2provided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2Q family member 2provided by MGI
Primary source
MGI:MGI:2388672
See related
Ensembl:ENSMUSG00000032307 AllianceGenome:MGI:2388672
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3010021M21Rik
Summary
Enables ubiquitin conjugating enzyme activity. Predicted to be involved in protein K48-linked ubiquitination. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human UBE2Q2 (ubiquitin conjugating enzyme E2 Q2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 7.3), testis adult (RPKM 6.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 B; 9 29.84 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (55056602..55114813)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (55149369..55207529)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene cholinergic receptor, nicotinic, beta polypeptide 4 Neighboring gene STARR-seq mESC enhancer starr_24182 Neighboring gene STARR-seq mESC enhancer starr_24183 Neighboring gene STARR-seq mESC enhancer starr_24184 Neighboring gene STARR-seq mESC enhancer starr_24185 Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene Neighboring gene STARR-seq mESC enhancer starr_24186 Neighboring gene F-box protein 22 Neighboring gene neuregulin 4 Neighboring gene serpine1 mRNA binding protein 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Demonstration of ubiquitin thiolester formation of UBE2Q2 (UBCi), a novel ubiquitin-conjugating enzyme with implantation site-specific expression. Melner MH, et al. Biol Reprod, 2006 Sep. PMID 16760379
  2. [Ubiquitin-conjugating enzyme UBE2Q2 participates in HUWE1-mediated protection on renal tubulointerstitial fibrosis]. Wang Z, et al. Sheng Li Xue Bao, 2022 Feb 25. PMID 35199132
  3. Extensive cryptic splicing upon loss of RBM17 and TDP43 in neurodegeneration models. Tan Q, et al. Hum Mol Genet, 2016 Dec 1. PMID 28007900, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [Ubiquitin-conjugating enzyme UBE2Q2 participates in HUWE1-mediated protection on renal tubulointerstitial fibrosis].
    Title: [Ubiquitin-conjugating enzyme UBE2Q2 participates in HUWE1-mediated protection on renal tubulointerstitial fibrosis].
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC19370

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein K48-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin-conjugating enzyme E2 Q2
Names
E2 ubiquitin-conjugating enzyme Q2
ubiquitin carrier protein Q2
ubiquitin-conjugating enzyme E2Q (putative) 2
ubiquitin-protein ligase Q2
NP_001333586.1
NP_001333587.1
NP_850931.2
XP_030099863.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346657.1 → NP_001333586.1  ubiquitin-conjugating enzyme E2 Q2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC156832, AC157328, BE953253
    Consensus CDS
    CCDS85677.1
    UniProtKB/TrEMBL
    D3Z647
    Related
    ENSMUSP00000113336.2, ENSMUST00000121677.8

  2. NM_001346658.1 → NP_001333587.1  ubiquitin-conjugating enzyme E2 Q2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC157328, AK076148, BE953253
    Consensus CDS
    CCDS85678.1
    UniProtKB/Swiss-Prot
    Q8K2Z8
    Related
    ENSMUSP00000112745.2, ENSMUST00000122441.2
    Conserved Domains (1) summary
    cd00195
    Location:86 → 242
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  3. NM_180600.3 → NP_850931.2  ubiquitin-conjugating enzyme E2 Q2 isoform 1

    See identical proteins and their annotated locations for NP_850931.2

    Status: VALIDATED

    Source sequence(s)
    AI227508, AK042515, AK150776
    Consensus CDS
    CCDS23201.1
    UniProtKB/Swiss-Prot
    Q3UBX3, Q3V3A5, Q8BUN2, Q8BVX5, Q8K2Z8
    Related
    ENSMUSP00000059798.9, ENSMUST00000059555.15
    Conserved Domains (1) summary
    cl00154
    Location:209 → 365
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    55056602..55114813
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244003.2 → XP_030099863.1  ubiquitin-conjugating enzyme E2 Q2 isoform X1

    Conserved Domains (1) summary
    cd00195
    Location:60 → 216
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RNA

  1. XR_004935303.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2Z8.2 GenPept UniProtKB/Swiss-Prot:Q8K2Z8

Gene LinkOut

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