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Slc30a9 solute carrier family 30 (zinc transporter), member 9 [ Mus musculus (house mouse) ]

Gene ID: 109108, updated on 11-Apr-2024

Summary

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Official Symbol
Slc30a9provided by MGI
Official Full Name
solute carrier family 30 (zinc transporter), member 9provided by MGI
Primary source
MGI:MGI:1923690
See related
Ensembl:ENSMUSG00000029221 AllianceGenome:MGI:1923690
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HUEL; GAC63; znT-9; 2310024J23Rik
Summary
Enables chromatin binding activity; nuclear receptor binding activity; and nuclear receptor coactivator activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasmic vesicle; cytoskeleton; and endoplasmic reticulum. Predicted to be active in nucleus. Is expressed in cranial ganglion and urethra. Orthologous to human SLC30A9 (solute carrier family 30 member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 23.5), frontal lobe adult (RPKM 21.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Slc30a9 in Genome Data Viewer
Location:
5 C3.1; 5 36.02 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (67464298..67513485)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (67306955..67356142)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40314 Neighboring gene STARR-positive B cell enhancer ABC_E3579 Neighboring gene STARR-seq mESC enhancer starr_13313 Neighboring gene transmembrane protein 33 Neighboring gene CRISPRi-validated cis-regulatory element for Bend4 and Slc30a9 Neighboring gene STARR-seq mESC enhancer starr_13315 Neighboring gene STARR-seq mESC enhancer starr_13316 Neighboring gene BEN domain containing 4 Neighboring gene predicted gene, 33345 Neighboring gene predicted gene 42632

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Role of GAC63 in transcriptional activation mediated by the aryl hydrocarbon receptor. Chen YH, et al. J Biol Chem, 2006 May 5. PMID 16513642, Free PMC Article
  2. The novel human HUEL (C4orf1) protein shares homology with the DNA-binding domain of the XPA DNA repair protein and displays nuclear translocation in a cell cycle-dependent manner. Sim DL, et al. Int J Biochem Cell Biol, 2002 May. PMID 11906820
  3. GAC63, a GRIP1-dependent nuclear receptor coactivator. Chen YH, et al. Mol Cell Biol, 2005 Jul. PMID 15988012, Free PMC Article
  4. Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub. Forrest MP, et al. Nat Commun, 2023 Feb 17. PMID 36808153, Free PMC Article
  5. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (5) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclear receptor coactivator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables zinc ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intracellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular zinc ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in zinc ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in zinc ion transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
proton-coupled zinc antiporter SLC30A9, mitochondrial
Names
GRIP1-associated coactivator 1
GRIP1-associated coactivator 63
zinc transporter 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310629.1 → NP_001297558.1  proton-coupled zinc antiporter SLC30A9, mitochondrial isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK038559, AK082853, BY237302, CX568220
    Consensus CDS
    CCDS80294.1
    UniProtKB/TrEMBL
    B2RU82, F8WHL1
    Related
    ENSMUSP00000109306.3, ENSMUST00000113676.6
    Conserved Domains (3) summary
    TIGR00598
    Location:103 → 188
    rad14; DNA repair protein
    pfam01545
    Location:230 → 429
    Cation_efflux; Cation efflux family
    pfam12137
    Location:489 → 547
    RapA_C; RNA polymerase recycling family C-terminal

  2. NM_178651.4 → NP_848766.2  proton-coupled zinc antiporter SLC30A9, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_848766.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK035541, AK082853, BY237302
    Consensus CDS
    CCDS39103.1
    UniProtKB/Swiss-Prot
    Q5IRJ6, Q66L46, Q7TNE9, Q8BGX8, Q8BUR1, Q8BZP2, Q8K2E0, Q8K376, Q8R0P1, Q9JK46
    UniProtKB/TrEMBL
    B2RU82
    Related
    ENSMUSP00000124047.2, ENSMUST00000162372.8
    Conserved Domains (3) summary
    TIGR00598
    Location:123 → 208
    rad14; DNA repair protein
    pfam01545
    Location:250 → 449
    Cation_efflux; Cation efflux family
    pfam12137
    Location:509 → 567
    RapA_C; RNA polymerase recycling family C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    67464298..67513485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5IRJ6.2 GenPept UniProtKB/Swiss-Prot:Q5IRJ6

Gene LinkOut

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