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SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone [ Homo sapiens (human) ]

Gene ID: 10910, updated on 7-Apr-2024

Summary

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Official Symbol
SUGT1provided by HGNC
Official Full Name
SGT1 homolog, MIS12 kinetochore complex assembly cochaperoneprovided by HGNC
Primary source
HGNC:HGNC:16987
See related
Ensembl:ENSG00000165416 MIM:604098; AllianceGenome:HGNC:16987
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SGT1
Summary
This gene encodes a highly conserved nuclear protein involved in kinetochore function and required for the G1/S and G2/M transitions. This protein interacts with heat shock protein 90. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene have been defined on several different chromosomes. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in brain (RPKM 4.1), testis (RPKM 3.2) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See SUGT1 in Genome Data Viewer
Location:
13q14.3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (52652836..52700909)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (51868272..51916337)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (53226971..53275044)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7793 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7794 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:53226721-53227222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7795 Neighboring gene SUGT1 divergent transcript Neighboring gene NANOG hESC enhancer GRCh37_chr13:53286351-53286901 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:53294479-53295260 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:53295261-53296041 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:53296347-53296555 Neighboring gene chondromodulin Neighboring gene NANOG hESC enhancer GRCh37_chr13:53311525-53312026 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:53353321-53353820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:53361012-53361528 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:53361529-53362044 Neighboring gene microRNA 759

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Hsp90 and its co-chaperone, Sgt1, as autoantigens in dilated cardiomyopathy. Kapustian LL, et al. Heart Vessels, 2013 Jan. PMID 22286152
  2. Nuclear translocation of Sgt1 depends on its phosphorylation state. Prus W, et al. Int J Biochem Cell Biol, 2011 Dec. PMID 21864708
  3. Overexpression of SUGT1 in human colorectal cancer and its clinicopathological significance. Iwatsuki M, et al. Int J Oncol, 2010 Mar. PMID 20126976
  4. Sgt1 plays polo during cell division. Martins T, et al. Cell Cycle, 2009 Apr 15. PMID 19305138
  5. Sgt1 has co-chaperone properties and is up-regulated by heat shock. Zabka M, et al. Biochem Biophys Res Commun, 2008 May 23. PMID 18358234

See all (124) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SUGT1 controls susceptibility to HIV-1 infection by stabilizing microtubule plus-ends.
    Title: SUGT1 controls susceptibility to HIV-1 infection by stabilizing microtubule plus-ends.
  2. REVIEW: cellular function of S100A6 and its ligands, CacyBP/SIP and Sgt1
    Title: Current view on cellular function of S100A6 and its ligands, CacyBP/SIP and Sgt1.
  3. the SGT1-HSP90 complex contributes to the E3 ligase activity of the CUL4A complex that is necessary for CENP-A ubiquitylation and CENP-A deposition at the centromere.
    Title: SGT1-HSP90 complex is required for CENP-A deposition at centromeres.
  4. Data suggest that PHLPP1 plays an important role in assembly of kinetochores by counteracting RNF41-mediated SGT1 degradation. (PHLPP1 = PH domain and leucine rich repeat protein phosphatase 1; RNF41 = ring finger protein 41; SGT1 = suppressor of G2 allele of SKP1)
    Title: Interplay between the phosphatase PHLPP1 and E3 ligase RNF41 stimulates proper kinetochore assembly via the outer-kinetochore protein SGT1.
  5. Fusion of human SGT1 (hSGT1) to NOD1 LRR significantly enhanced the solubility, and the fusion protein was stabilized by coexpression of mouse Hsp90alpha.
    Title: Application of SGT1-Hsp90 chaperone complex for soluble expression of NOD1 LRR domain in E. coli.
  6. Data (including data from studies using purified proteins/hepatocyte lysates) suggest eEF1A1/Sgt1a interact as multimer; D2/D3 domains of eEF1A1 and TPR domain of Sgt1 are involved in multimer formation; Sgt1 competes with viral RNA to bind to eEF1A.
    Title: Translation elongation factor eEF1A1 is a novel partner of a multifunctional protein Sgt1.
  7. Data suggest that SspH2 (ubiquitin ligase effector from Salmonella typhimurium) ubiquitination activity and protein stability is enhanced by SGT1.
    Title: The Salmonella type III effector SspH2 specifically exploits the NLR co-chaperone activity of SGT1 to subvert immunity.
  8. our data revealed a previously uncovered role of SGT1 in gastric cancer development, and suggested that SGT1 could be a promising anti-cancer target to against gastric cancer
    Title: SGT1 regulates Akt signaling by promoting beta-TrCP-dependent PHLPP1 degradation in gastric cancer cells.
  9. Chp-1 and melusin can interact with cochaperones PP5 and Sgt1 and with each other in an ATP-dependent manner
    Title: Dynamic nucleotide-dependent interactions of cysteine- and histidine-rich domain (CHORD)-containing Hsp90 cochaperones Chp-1 and melusin with cochaperones PP5 and Sgt1.
  10. Plk1 is required for the kinetochore localization of Sgt1 and phosphorylates serine 331 of Sgt1 at the kinetochores.
    Title: Plk1 phosphorylates Sgt1 at the kinetochores to promote timely kinetochore-microtubule attachment.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lncRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in kinetochore assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein stability IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in skeletal muscle satellite cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in spindle organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ubiquitin ligase complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
protein SGT1 homolog
Names
SGT1, suppressor of G2 allele of SKP1
putative 40-6-3 protein
suppressor of G2 allele of SKP1, S. cerevisiae, homolog of

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029521.3 RefSeqGene

    Range
    5002..53075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130912.3 → NP_001124384.1  protein SGT1 homolog isoform B

    See identical proteins and their annotated locations for NP_001124384.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as B or SGT1.2) encodes the longest isoform (B).
    Source sequence(s)
    AL139089
    Consensus CDS
    CCDS45050.1
    UniProtKB/Swiss-Prot
    A2A303, Q5JAK5, Q5TAM6, Q6VXY6, Q9Y2Z0
    UniProtKB/TrEMBL
    A8K5T7
    Related
    ENSP00000367208.4, ENST00000343788.10
    Conserved Domains (2) summary
    PLN03088
    Location:21 → 365
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    sd00006
    Location:44 → 74
    TPR; TPR repeat [structural motif]

  2. NM_001320831.2 → NP_001307760.1  protein SGT1 homolog isoform C

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon and contains an alternate exon in the 5' region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (C) has a distinct N-terminus and is shorter than isoform B.
    Source sequence(s)
    AL139089
    UniProtKB/TrEMBL
    B4DYC6
    Conserved Domains (2) summary
    sd00006
    Location:22 → 52
    TPR; TPR repeat [structural motif]
    cl26005
    Location:8 → 277
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

  3. NM_006704.5 → NP_006695.1  protein SGT1 homolog isoform A

    See identical proteins and their annotated locations for NP_006695.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as A) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (A) is shorter than isoform B.
    Source sequence(s)
    AL139089
    Consensus CDS
    CCDS9436.1
    UniProtKB/TrEMBL
    A8K7W3
    Related
    ENSP00000308067.7, ENST00000310528.9
    Conserved Domains (2) summary
    sd00006
    Location:44 → 74
    TPR; TPR repeat [structural motif]
    cl26005
    Location:21 → 333
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    52652836..52700909
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020365.2 → XP_016875854.1  protein SGT1 homolog isoform X1

    UniProtKB/TrEMBL
    A8K5T7

  2. XM_047430066.1 → XP_047286022.1  protein SGT1 homolog isoform X3

  3. XM_047430065.1 → XP_047286021.1  protein SGT1 homolog isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    51868272..51916337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374052.1 → XP_054230027.1  protein SGT1 homolog isoform X1

  2. XM_054374053.1 → XP_054230028.1  protein SGT1 homolog isoform X2

  3. XM_054374054.1 → XP_054230029.1  protein SGT1 homolog isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y2Z0.3 GenPept UniProtKB/Swiss-Prot:Q9Y2Z0

Gene LinkOut

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