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Rars2 arginyl-tRNA synthetase 2, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 109093, updated on 21-Apr-2024

Summary

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Official Symbol
Rars2provided by MGI
Official Full Name
arginyl-tRNA synthetase 2, mitochondrialprovided by MGI
Primary source
MGI:MGI:1923596
See related
Ensembl:ENSMUSG00000028292 AllianceGenome:MGI:1923596
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rarsl; PRO1992; 1500002I10Rik
Summary
Predicted to enable arginine-tRNA ligase activity. Predicted to be involved in arginyl-tRNA aminoacylation and mitochondrial translation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including alimentary system; hemolymphoid system; nervous system; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 6. Orthologous to human RARS2 (arginyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 8.5), placenta adult (RPKM 7.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 A5; 4 16.84 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (34614941..34660167)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (34614957..34660167)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09910 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:34497692-34497879 Neighboring gene akirin 2 Neighboring gene STARR-seq mESC enhancer starr_09912 Neighboring gene origin recognition complex, subunit 3 Neighboring gene solute carrier family 35 (CMP-sialic acid transporter), member 1 Neighboring gene STARR-positive B cell enhancer ABC_E6160 Neighboring gene cilia and flagella associated protein 206 Neighboring gene STARR-seq mESC enhancer starr_09914

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  2. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables arginine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arginine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in arginyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable arginine--tRNA ligase, mitochondrial
Names
argRS
arginine--tRNA ligase
arginyl-tRNA synthetase 2, mitochondrial (putative)
probable arginyl-tRNA synthetase, mitochondrial
NP_852071.2
XP_011248204.1
XP_017175401.1
XP_030108934.1
XP_030108935.1
XP_030108936.1
XP_036019465.1
XP_036019466.1
XP_036019467.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181406.4 → NP_852071.2  probable arginine--tRNA ligase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_852071.2

    Status: VALIDATED

    Source sequence(s)
    AK075721, AK166986, AL928738, AW120679
    Consensus CDS
    CCDS18029.1
    UniProtKB/Swiss-Prot
    Q3U186, Q8QZU7
    Related
    ENSMUSP00000029968.8, ENSMUST00000029968.14
    Conserved Domains (3) summary
    cd00671
    Location:126 → 388
    ArgRS_core; catalytic core domain of arginyl-tRNA synthetases
    COG0018
    Location:30 → 578
    ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    cl12020
    Location:425 → 578
    Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

RNA

  1. NR_151507.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK075721, AK166986, AL928738, AW120679

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    34614941..34660167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163573.1 → XP_036019466.1  probable arginine--tRNA ligase, mitochondrial isoform X2

    Conserved Domains (1) summary
    COG0018
    Location:9 → 550
    ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

  2. XM_030253074.2 → XP_030108934.1  probable arginine--tRNA ligase, mitochondrial isoform X4

    Conserved Domains (1) summary
    COG0018
    Location:2 → 403
    ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

  3. XM_011249902.3 → XP_011248204.1  probable arginine--tRNA ligase, mitochondrial isoform X3

    Conserved Domains (1) summary
    COG0018
    Location:49 → 423
    ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

  4. XM_017319912.3 → XP_017175401.1  probable arginine--tRNA ligase, mitochondrial isoform X3

    Conserved Domains (1) summary
    COG0018
    Location:49 → 423
    ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

  5. XM_030253075.2 → XP_030108935.1  probable arginine--tRNA ligase, mitochondrial isoform X5

    Conserved Domains (1) summary
    COG0018
    Location:9 → 347
    ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

  6. XM_030253076.2 → XP_030108936.1  probable arginine--tRNA ligase, mitochondrial isoform X5

    Conserved Domains (1) summary
    COG0018
    Location:9 → 347
    ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

  7. XM_036163574.1 → XP_036019467.1  probable arginine--tRNA ligase, mitochondrial isoform X5

    Conserved Domains (1) summary
    COG0018
    Location:9 → 347
    ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

  8. XM_036163572.1 → XP_036019465.1  probable arginine--tRNA ligase, mitochondrial isoform X1

    Conserved Domains (1) summary
    COG0018
    Location:20 → 568
    ArgS; Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U186.1 GenPept UniProtKB/Swiss-Prot:Q3U186

Gene LinkOut

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