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Inka2 inka box actin regulator 2 [ Mus musculus (house mouse) ]

Gene ID: 109050, updated on 28-Apr-2024

Summary

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Official Symbol
Inka2provided by MGI
Official Full Name
inka box actin regulator 2provided by MGI
Primary source
MGI:MGI:1923497
See related
Ensembl:ENSMUSG00000048458 AllianceGenome:MGI:1923497
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam212b; 6530418L21Rik
Summary
Predicted to enable protein kinase binding activity and protein serine/threonine kinase inhibitor activity. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in central nervous system; dorsal root ganglion; heart; and olfactory epithelium. Orthologous to human INKA2 (inka box actin regulator 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 15.1), frontal lobe adult (RPKM 12.0) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 F2.2; 3 46.44 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (105611915..105628158)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (105704599..105720842)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, Shal-related family, member 3, opposite strand Neighboring gene potassium voltage-gated channel, Shal-related family, member 3 Neighboring gene STARR-positive B cell enhancer ABC_E6095 Neighboring gene STARR-positive B cell enhancer ABC_E8804 Neighboring gene STARR-positive B cell enhancer ABC_E2091 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:105507469-105507578 Neighboring gene DEAD box helicase 20 Neighboring gene RAS-related protein 1a Neighboring gene STARR-positive B cell enhancer ABC_E10203 Neighboring gene STARR-positive B cell enhancer ABC_E11208 Neighboring gene predicted gene 5547

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inka2 expression in smooth muscle cells and its involvement in cell migration. Yamada S, et al. Biochem Biophys Res Commun, 2023 Feb 5. PMID 36586159
  2. Control of cell migration by the novel protein phosphatase-2A interacting protein inka2. Akiyama H, et al. Cell Tissue Res, 2020 Jun. PMID 31975032
  3. Expression profiles of inka2 in the murine nervous system. Iwasaki Y, et al. Gene Expr Patterns, 2015 Sep-Nov. PMID 26292052
  4. Inka2, a novel Pak4 inhibitor, regulates actin dynamics in neuronal development. Yamada S, et al. PLoS Genet, 2022 Oct. PMID 36301793, Free PMC Article
  5. Transcriptome profiling of the Olig2-expressing astrocyte subtype reveals their unique molecular signature. Ohayon D, et al. iScience, 2021 Jul 23. PMID 34296073, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inka2 expression in smooth muscle cells and its involvement in cell migration.
    Title: Inka2 expression in smooth muscle cells and its involvement in cell migration.
  2. Inka2, a novel Pak4 inhibitor, regulates actin dynamics in neuronal development.
    Title: Inka2, a novel Pak4 inhibitor, regulates actin dynamics in neuronal development.
  3. Control of cell migration by the novel protein phosphatase-2A interacting protein inka2.
    Title: Control of cell migration by the novel protein phosphatase-2A interacting protein inka2.
  4. In the present study, we identified a novel gene, designated as inka2, which is related to inka1
    Title: Expression profiles of inka2 in the murine nervous system.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
PAK4-inhibitor INKA2
Names
MInca-r
family with sequence similarity 212, member B
induced in neural crest by AP2-alpha protein-related homolog
protein FAM212B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163356.1 → NP_001156828.1  PAK4-inhibitor INKA2 isoform 2

    See identical proteins and their annotated locations for NP_001156828.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) utilizes an alternate first exon, compared to variant 2, resulting in (predicted) use of an internal translation start site and a shorter protein isoform (2).
    Source sequence(s)
    AC139316, AK078368
    Consensus CDS
    CCDS51035.1
    UniProtKB/Swiss-Prot
    Q80VY2
    Related
    ENSMUSP00000095874.3, ENSMUST00000098273.3
    Conserved Domains (1) summary
    pfam15342
    Location:120 → 159
    FAM212; FAM212 family

  2. NM_175398.4 → NP_780607.2  PAK4-inhibitor INKA2 isoform 1

    See identical proteins and their annotated locations for NP_780607.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AC139316, AK078368, BY290400
    Consensus CDS
    CCDS17710.1
    UniProtKB/Swiss-Prot
    Q80VY2, Q8C5H0, Q8CCA1
    Related
    ENSMUSP00000069212.8, ENSMUST00000066610.8
    Conserved Domains (1) summary
    pfam15342
    Location:139 → 178
    FAM212; FAM212 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    105611915..105628158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80VY2.1 GenPept UniProtKB/Swiss-Prot:Q80VY2

Gene LinkOut

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