Nabp1 nucleic acid binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nabp1provided by MGI
Official Full Name: nucleic acid binding protein 1provided by MGI
Primary source: MGI:MGI:1923258
See related: Ensembl:ENSMUSG00000026107 AllianceGenome:MGI:1923258
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nbp1; Ssb2; Obfc2a; 4930434H03Rik; 4930442A21Rik; 4930488J04Rik; 4933440J18Rik; 5830411E10Rik
Summary: Enables RNA binding activity and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination; mitotic G2/M transition checkpoint; and response to ionizing radiation. Located in chromosome, telomeric region and nucleus. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human NABP1 (nucleic acid binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 17.6), placenta adult (RPKM 13.4) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C1.1; 1 26.58 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (51504127..51517634, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (51464968..51478475, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ssb1 is likely able to compensate for the loss of Ssb2 in mice.
Title: Ssb2/Nabp1 is dispensable for thymic maturation, male fertility, and DNA repair in mice.
NABP1 binds single-stranded nucleic acids, but not double-stranded DNA, suggesting that it functions as a single-stranded nucleic acid binding protein
Title: NABP1, a novel RORgamma-regulated gene encoding a single-stranded nucleic-acid-binding protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

RH125275 (e-PCR)
- UniSTS:162097

NoName (e-PCR)
- UniSTS:234125

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2/M transition checkpoint	ISO Inferred from Sequence Orthology more info
involved_in mitotic cell cycle checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to ionizing radiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to ionizing radiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of SOSS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SOSS complex	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in site of double-strand break	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: SOSS complex subunit B2

Names: SOSS-B2; oligonucleotide/oligosaccharide-binding fold containing 2A; oligonucleotide/oligosaccharide-binding fold-containing protein 2A; sensor of single-strand DNA complex subunit B2; sensor of ssDNA subunit B2; single-stranded DNA-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310548.1 → NP_001297477.1 SOSS complex subunit B2 isoform b

See identical proteins and their annotated locations for NP_001297477.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice junction in the 5' end compared to variant 1, which results in translation from a downstream AUG. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).

Source sequence(s)

AC125518, AK167652, AY880264, BB609822, BY089463

Consensus CDS

CCDS78580.1

UniProtKB/Swiss-Prot

Q8BGW5

Related

ENSMUSP00000140557.2, ENSMUST00000185534.2

Conserved Domains (1) summary

PLN02216
Location:36 → 71

PLN02216; protein SRG1
NM_001310549.1 → NP_001297478.1 SOSS complex subunit B2 isoform b

See identical proteins and their annotated locations for NP_001297478.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice junction in the 5' end compared to variant 1, which results in translation from a downstream AUG. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).

Source sequence(s)

AK167652, AY880264, BB609822

Consensus CDS

CCDS78580.1

UniProtKB/Swiss-Prot

Q8BGW5

Related

ENSMUSP00000140469.2, ENSMUST00000188204.7

Conserved Domains (1) summary

PLN02216
Location:36 → 71

PLN02216; protein SRG1
NM_028696.3 → NP_082972.2 SOSS complex subunit B2 isoform a

See identical proteins and their annotated locations for NP_082972.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).

Source sequence(s)

AY880264

Consensus CDS

CCDS35559.1

UniProtKB/Swiss-Prot

Q8BGW5, Q8C154, Q8C164

UniProtKB/TrEMBL

Q8R2P2

Related

ENSMUSP00000027279.6, ENSMUST00000027279.12

Conserved Domains (1) summary

cd04491
Location:22 → 99

SoSSB_OBF; SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In ...