E2f8 E2F transcription factor 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: E2f8provided by MGI
Official Full Name: E2F transcription factor 8provided by MGI
Primary source: MGI:MGI:1922038
See related: Ensembl:ENSMUSG00000046179 AllianceGenome:MGI:1922038
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4432406C08Rik
Summary: Enables DNA binding activity; DNA-binding transcription repressor activity; and identical protein binding activity. Involved in several processes, including hepatocyte differentiation; regulation of cell cycle process; and trophoblast giant cell differentiation. Acts upstream of or within cell population proliferation. Located in nucleus. Is expressed in central nervous system and retina. Orthologous to human E2F8 (E2F transcription factor 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver E14.5 (RPKM 17.2), liver E14 (RPKM 16.7) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B4; 7 31.11 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (48516177..48531821, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (48866429..48882073, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADP Ribosylation Factor 6 Relieves Airway Inflammation and Remodeling by Inhibiting Ovalbumin Induced-Epithelial Mesenchymal Transition in Experimental Asthma, Possibly by Regulating of E2F Transcription Factor 8.
Title: ADP Ribosylation Factor 6 Relieves Airway Inflammation and Remodeling by Inhibiting Ovalbumin Induced-Epithelial Mesenchymal Transition in Experimental Asthma, Possibly by Regulating of E2F Transcription Factor 8.
Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation.
Title: Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation.
E2F7 Is a Potent Inhibitor of Liver Tumor Growth in Adult Mice.
Title: E2F7 Is a Potent Inhibitor of Liver Tumor Growth in Adult Mice.
findings indicated that E2F8 is involved in gluconeogenesis and insulin resistance and may represent a new therapeutic target in T2DM prevention
Title: Identification of E2F8 as a Transcriptional Regulator of Gluconeogenesis in Primary Mouse Hepatocytes.
Loss of E2F8 expression is associated with tumorigenesis in liver.
Title: The Polyploid State Plays a Tumor-Suppressive Role in the Liver.
we identified atypical E2fs to be essential for polyploidization in the pancreas and discovered that postnatal induced loss of both atypical E2fs in many organs is compatible with life until old age
Title: Atypical E2f functions are critical for pancreas polyploidization.
E2F8-mediated transcriptional repression is a critical tumor suppressor mechanism during postnatal liver development
Title: E2f8 mediates tumor suppression in postnatal liver development.
transcription factor E2F8 is involved in the polyploidization during mouse and human decidualization
Title: Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization.
Rb and E2F8 collaborate to promote DNA replication.
Title: Inactivation of Rb and E2f8 synergizes to trigger stressed DNA replication during erythroid terminal differentiation.
The results identify E2F8 as a repressor and E2F1 as an activator of a transcriptional network controlling polyploidization in mammalian cells.
Title: E2F8 is essential for polyploidization in mammalian cells.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell cycle comprising mitosis without cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chorionic trophoblast cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fibroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in hepatocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA endoreduplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in trophoblast giant cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor E2F8

Names: E2f family member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013368.5 → NP_001013386.2 transcription factor E2F8

See identical proteins and their annotated locations for NP_001013386.2

Status: VALIDATED

Source sequence(s)

AK084513, AK160240, BX528987

Consensus CDS

CCDS39967.1

UniProtKB/Swiss-Prot

Q3U4W2, Q497V7, Q58FA4, Q5PRE4, Q8BQJ5, Q8C3Y5

Related

ENSMUSP00000056778.9, ENSMUST00000058745.15

Conserved Domains (2) summary

PHA03247
Location:497 → 830

PHA03247; large tegument protein UL36; Provisional

pfam02319
Location:114 → 182

E2F_TDP; E2F/DP family winged-helix DNA-binding domain
NM_001360812.1 → NP_001347741.1 transcription factor E2F8

Status: VALIDATED

Source sequence(s)

AC124977, BC086675, BX528987

Consensus CDS

CCDS39967.1

UniProtKB/Swiss-Prot

Q3U4W2, Q497V7, Q58FA4, Q5PRE4, Q8BQJ5, Q8C3Y5

Related

ENSMUSP00000112883.2, ENSMUST00000119223.2

Conserved Domains (2) summary

PHA03247
Location:497 → 830

PHA03247; large tegument protein UL36; Provisional

pfam02319
Location:114 → 182

E2F_TDP; E2F/DP family winged-helix DNA-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

48516177..48531821 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006540554.3 → XP_006540617.1 transcription factor E2F8 isoform X1

See identical proteins and their annotated locations for XP_006540617.1

UniProtKB/Swiss-Prot

Q3U4W2, Q497V7, Q58FA4, Q5PRE4, Q8BQJ5, Q8C3Y5

Conserved Domains (2) summary

PHA03247
Location:497 → 830

PHA03247; large tegument protein UL36; Provisional

pfam02319
Location:114 → 182

E2F_TDP; E2F/DP family winged-helix DNA-binding domain