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Trmt10a tRNA methyltransferase 10A [ Mus musculus (house mouse) ]

Gene ID: 108943, updated on 3-Apr-2024

Summary

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Official Symbol
Trmt10aprovided by MGI
Official Full Name
tRNA methyltransferase 10Aprovided by MGI
Primary source
MGI:MGI:1920421
See related
Ensembl:ENSMUSG00000004127 AllianceGenome:MGI:1920421
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rnmtd2; Rg9mtd2; 3110023L08Rik
Summary
Predicted to enable tRNA (guanine(9)-N(1))-methyltransferase activity and tRNA binding activity. Acts upstream of or within magnesium ion homeostasis. Predicted to be located in actin cytoskeleton and nucleolus. Predicted to be active in cytosol and nucleoplasm. Is expressed in Meckel's cartilage; skeleton; and ventral grey horn. Orthologous to human TRMT10A (tRNA methyltransferase 10A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 8.1), CNS E11.5 (RPKM 2.9) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Trmt10a in Genome Data Viewer
Location:
3 G3; 3 64.09 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (137849214..137865582)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (138143448..138159821)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1110002E22 gene Neighboring gene STARR-seq mESC enhancer starr_09105 Neighboring gene predicted gene, 52617 Neighboring gene microsomal triglyceride transfer protein Neighboring gene STARR-positive B cell enhancer mm9_chr3:137778444-137778744 Neighboring gene STARR-seq mESC enhancer starr_09106 Neighboring gene STARR-positive B cell enhancer ABC_E3473 Neighboring gene RIKEN cDNA 4930579F01 gene Neighboring gene STARR-positive B cell enhancer mm9_chr3:137861123-137861424 Neighboring gene RIKEN cDNA 0610031O16 gene Neighboring gene alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. White JK, et al. Cell, 2013 Jul 18. PMID 23870131, Free PMC Article
  2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Clone Names

  • MGC107421, MGC116571

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (guanosine(9)-N1)-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within magnesium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA N1-guanine methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA N1-guanine methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA methylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tRNA methyltransferase 10 homolog A
Names
RNA (guanine-9-) methyltransferase domain containing 2
tRNA (guanine(9)-N(1))-methyltransferase TRMT10A
NP_001335125.2
NP_001335126.2
NP_001391294.1
NP_001391297.1
NP_001391298.1
NP_001391299.1
NP_001391300.1
NP_001391301.1
NP_001391302.1
NP_001391303.1
NP_001391304.1
NP_001391305.1
NP_001391307.1
NP_001391308.1
NP_001391309.1
NP_001391310.1
NP_001391311.1
NP_001391312.1
NP_001391313.1
NP_001391314.1
NP_001391315.1
NP_780598.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348196.2 → NP_001335125.2  tRNA methyltransferase 10 homolog A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131122
    Consensus CDS
    CCDS17866.1
    UniProtKB/TrEMBL
    A0A0R4J205
    Related
    ENSMUSP00000125749.3, ENSMUST00000162864.8

  2. NM_001348197.2 → NP_001335126.2  tRNA methyltransferase 10 homolog A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131122
    Consensus CDS
    CCDS17866.1
    UniProtKB/TrEMBL
    A0A0R4J205

  3. NM_001404365.1 → NP_001391294.1  tRNA methyltransferase 10 homolog A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131122
    UniProtKB/TrEMBL
    A0A0R4J205

  4. NM_001404368.1 → NP_001391297.1  tRNA methyltransferase 10 homolog A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131122
    UniProtKB/TrEMBL
    A0A0R4J205

  5. NM_001404369.1 → NP_001391298.1  tRNA methyltransferase 10 homolog A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131122
    UniProtKB/TrEMBL
    A0A0R4J205

  6. NM_001404370.1 → NP_001391299.1  tRNA methyltransferase 10 homolog A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131122
    UniProtKB/TrEMBL
    A0A0R4J205

  7. NM_001404371.1 → NP_001391300.1  tRNA methyltransferase 10 homolog A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131122
    UniProtKB/TrEMBL
    A0A0R4J205

  8. NM_001404372.1 → NP_001391301.1  tRNA methyltransferase 10 homolog A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131122
    UniProtKB/TrEMBL
    A0A0R4J205

  9. NM_001404373.1 → NP_001391302.1  tRNA methyltransferase 10 homolog A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131122
    UniProtKB/TrEMBL
    A0A0R4J205

  10. NM_001404374.1 → NP_001391303.1  tRNA methyltransferase 10 homolog A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131122
    UniProtKB/TrEMBL
    A0A0R4J205

  11. NM_001404375.1 → NP_001391304.1  tRNA methyltransferase 10 homolog A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131122
    UniProtKB/TrEMBL
    A0A0R4J205

  12. NM_001404376.1 → NP_001391305.1  tRNA methyltransferase 10 homolog A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131122
    UniProtKB/TrEMBL
    A0A0R4J205

  13. NM_001404378.1 → NP_001391307.1  tRNA methyltransferase 10 homolog A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131122
    UniProtKB/TrEMBL
    A0A0R4J205

  14. NM_001404379.1 → NP_001391308.1  tRNA methyltransferase 10 homolog A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131122
    UniProtKB/TrEMBL
    A0A0R4J205

  15. NM_001404380.1 → NP_001391309.1  tRNA methyltransferase 10 homolog A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131122
    UniProtKB/TrEMBL
    A0A0R4J205

  16. NM_001404381.1 → NP_001391310.1  tRNA methyltransferase 10 homolog A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131122
    UniProtKB/TrEMBL
    A0A0R4J205

  17. NM_001404382.1 → NP_001391311.1  tRNA methyltransferase 10 homolog A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC131122

  18. NM_001404383.1 → NP_001391312.1  tRNA methyltransferase 10 homolog A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC131122

  19. NM_001404384.1 → NP_001391313.1  tRNA methyltransferase 10 homolog A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC131122

  20. NM_001404385.1 → NP_001391314.1  tRNA methyltransferase 10 homolog A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC131122

  21. NM_001404386.1 → NP_001391315.1  tRNA methyltransferase 10 homolog A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC131122

  22. NM_175389.6 → NP_780598.3  tRNA methyltransferase 10 homolog A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131122
    Consensus CDS
    CCDS17866.1
    UniProtKB/TrEMBL
    A0A0R4J205
    Related
    ENSMUSP00000042082.8, ENSMUST00000040321.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    137849214..137865582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C1Z8.2 GenPept UniProtKB/Swiss-Prot:Q8C1Z8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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