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Cdca2 cell division cycle associated 2 [ Mus musculus (house mouse) ]

Gene ID: 108912, updated on 11-Apr-2024

Summary

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Official Symbol
Cdca2provided by MGI
Official Full Name
cell division cycle associated 2provided by MGI
Primary source
MGI:MGI:1919787
See related
Ensembl:ENSMUSG00000048922 AllianceGenome:MGI:1919787
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610311M19Rik
Summary
Acts upstream of or within chromosome segregation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in chromosome and nucleus. Is expressed in several structures, including brain; liver; lung; metanephros; and retina nuclear layer. Orthologous to human CDCA2 (cell division cycle associated 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 12.3), CNS E11.5 (RPKM 7.2) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 D1; 14 34.66 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (67910629..67953290, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (67673180..67715841, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37012 Neighboring gene predicted gene, 38409 Neighboring gene predicted gene, 24981 Neighboring gene STARR-seq mESC enhancer starr_37015 Neighboring gene potassium channel tetramerisation domain containing 9 Neighboring gene gonadotropin releasing hormone 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores. Wurzenberger C, et al. J Cell Biol, 2012 Jul 23. PMID 22801782, Free PMC Article
  2. Tbx5-hedgehog molecular networks are essential in the second heart field for atrial septation. Xie L, et al. Dev Cell, 2012 Aug 14. PMID 22898775, Free PMC Article
  3. Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex. Ulmke PA, et al. Stem Cell Reports, 2021 Apr 13. PMID 33798452, Free PMC Article
  4. Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development. Naiman N, et al. Dev Cell, 2017 May 22. PMID 28535371, Free PMC Article
  5. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Ray JP, et al. Immunity, 2015 Oct 20. PMID 26410627, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromosome segregation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cell division cycle-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110162.1 → NP_001103632.1  cell division cycle-associated protein 2

    See identical proteins and their annotated locations for NP_001103632.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript.
    Source sequence(s)
    AK160223, AK166952, BC067009, CD354922
    Consensus CDS
    CCDS36962.2
    UniProtKB/Swiss-Prot
    Q14B71, Q8BSQ1, Q8CD75
    Related
    ENSMUSP00000127571.2, ENSMUST00000163100.8
    Conserved Domains (1) summary
    pfam15276
    Location:379 → 435
    PP1_bind; Protein phosphatase 1 binding

  2. NM_175384.4 → NP_780593.3  cell division cycle-associated protein 2

    See identical proteins and their annotated locations for NP_780593.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC067009, BC075682
    Consensus CDS
    CCDS36962.2
    UniProtKB/Swiss-Prot
    Q14B71, Q8BSQ1, Q8CD75
    Related
    ENSMUSP00000117847.3, ENSMUST00000150006.9
    Conserved Domains (1) summary
    pfam15276
    Location:379 → 435
    PP1_bind; Protein phosphatase 1 binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    67910629..67953290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247603.1 → XP_030103463.1  cell division cycle-associated protein 2 isoform X3

    Conserved Domains (1) summary
    pfam15276
    Location:379 → 434
    PP1_bind; Protein phosphatase 1 binding

  2. XM_030247602.2 → XP_030103462.1  cell division cycle-associated protein 2 isoform X2

    Conserved Domains (1) summary
    pfam15276
    Location:380 → 435
    PP1_bind; Protein phosphatase 1 binding

  3. XM_006518420.5 → XP_006518483.1  cell division cycle-associated protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006518483.1

    UniProtKB/Swiss-Prot
    Q14B71, Q8BSQ1, Q8CD75
    Conserved Domains (1) summary
    pfam15276
    Location:379 → 435
    PP1_bind; Protein phosphatase 1 binding

  4. XM_030247604.2 → XP_030103464.1  cell division cycle-associated protein 2 isoform X4

    Conserved Domains (1) summary
    pfam15276
    Location:379 → 434
    PP1_bind; Protein phosphatase 1 binding

  5. XM_011244913.4 → XP_011243215.1  cell division cycle-associated protein 2 isoform X3

    Conserved Domains (1) summary
    pfam15276
    Location:379 → 434
    PP1_bind; Protein phosphatase 1 binding

  6. XM_011244912.4 → XP_011243214.1  cell division cycle-associated protein 2 isoform X2

    Conserved Domains (1) summary
    pfam15276
    Location:380 → 435
    PP1_bind; Protein phosphatase 1 binding

  7. XM_030247605.1 → XP_030103465.1  cell division cycle-associated protein 2 isoform X6

    Conserved Domains (1) summary
    pfam15276
    Location:234 → 289
    PP1_bind; Protein phosphatase 1 binding

  8. XM_006518423.2 → XP_006518486.1  cell division cycle-associated protein 2 isoform X5

    Conserved Domains (1) summary
    pfam15276
    Location:234 → 289
    PP1_bind; Protein phosphatase 1 binding

  9. XM_011244915.4 → XP_011243217.1  cell division cycle-associated protein 2 isoform X7

    UniProtKB/TrEMBL
    D3YZE8
    Related
    ENSMUSP00000115633.2, ENSMUST00000132705.8
    Conserved Domains (1) summary
    pfam15276
    Location:380 → 435
    PP1_bind; Protein phosphatase 1 binding
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14B71.2 GenPept UniProtKB/Swiss-Prot:Q14B71

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