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Tbcd tubulin-specific chaperone d [ Mus musculus (house mouse) ]

Gene ID: 108903, updated on 5-Mar-2024

Summary

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Official Symbol
Tbcdprovided by MGI
Official Full Name
tubulin-specific chaperone dprovided by MGI
Primary source
MGI:MGI:1919686
See related
Ensembl:ENSMUSG00000039230 AllianceGenome:MGI:1919686
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0988; 2310057L06Rik; A030005L14Rik
Summary
Predicted to enable GTPase activator activity and beta-tubulin binding activity. Predicted to be involved in several processes, including cell-cell junction assembly; post-chaperonin tubulin folding pathway; and tubulin complex assembly. Predicted to be located in centrosome. Predicted to be active in lateral plasma membrane. Orthologous to human TBCD (tubulin folding cofactor D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 8.3), whole brain E14.5 (RPKM 7.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 E2; 11 85.41 cM
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (121342817..121507996)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (121451991..121617170)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr11:121282511-121282812 Neighboring gene fructosamine 3 kinase related protein Neighboring gene STARR-positive B cell enhancer mm9_chr11:121312999-121313300 Neighboring gene fructosamine 3 kinase Neighboring gene STARR-seq mESC enhancer starr_31381 Neighboring gene zinc finger protein 750 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:121420970-121421165 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 Neighboring gene STARR-seq mESC enhancer starr_31382 Neighboring gene predicted gene, 53659 Neighboring gene ribosomal protein, large, P0 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Stathmin, a microtubule-destabilizing protein, is dysregulated in spinal muscular atrophy. Wen HL, et al. Hum Mol Genet, 2010 May 1. PMID 20176735
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718
  3. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809
  4. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article
  5. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables beta-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in adherens junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in bicellular tight junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis involved in neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in post-chaperonin tubulin folding pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding ISO
Inferred from Sequence Orthology
more info
  
involved_in tubulin complex assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in lateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tubulin-specific chaperone D
Names
beta-tubulin cofactor D
tubulin-folding cofactor D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029878.4 → NP_084154.1  tubulin-specific chaperone D

    See identical proteins and their annotated locations for NP_084154.1

    Status: VALIDATED

    Source sequence(s)
    AK041464, AK050199, BY513705, CK622820
    Consensus CDS
    CCDS25778.1
    UniProtKB/Swiss-Prot
    Q8BYA0
    Related
    ENSMUSP00000099302.4, ENSMUST00000103013.10
    Conserved Domains (2) summary
    pfam12612
    Location:900 → 1090
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:63 → 887
    TFCD_C; Tubulin folding cofactor D C terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    121342817..121507996
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245468.2 → XP_030101328.1  tubulin-specific chaperone D isoform X3

    Conserved Domains (2) summary
    pfam12612
    Location:340 → 525
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:282 → 323
    TFCD_C; Tubulin folding cofactor D C terminal

  2. XM_006531973.5 → XP_006532036.1  tubulin-specific chaperone D isoform X1

    Conserved Domains (2) summary
    pfam12612
    Location:516 → 701
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:29 → 499
    TFCD_C; Tubulin folding cofactor D C terminal

  3. XM_006531974.5 → XP_006532037.1  tubulin-specific chaperone D isoform X2

    Conserved Domains (2) summary
    pfam12612
    Location:487 → 672
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:28 → 470
    TFCD_C; Tubulin folding cofactor D C terminal

  4. XM_006531975.1 → XP_006532038.1  tubulin-specific chaperone D isoform X3

    Conserved Domains (2) summary
    pfam12612
    Location:340 → 525
    TFCD_C; Tubulin folding cofactor D C terminal
    cl19887
    Location:282 → 323
    TFCD_C; Tubulin folding cofactor D C terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BYA0.1 GenPept UniProtKB/Swiss-Prot:Q8BYA0

Gene LinkOut

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