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Zfta zinc finger translocation associated [ Mus musculus (house mouse) ]

Gene ID: 108899, updated on 3-Apr-2024

Summary

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Official Symbol
Zftaprovided by MGI
Official Full Name
zinc finger translocation associatedprovided by MGI
Primary source
MGI:MGI:1919667
See related
Ensembl:ENSMUSG00000053080 AllianceGenome:MGI:1919667
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2700081O15Rik
Summary
Predicted to be involved in negative regulation of transcription, DNA-templated. Is expressed in forebrain. Orthologous to human ZFTA (zinc finger translocation associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 43.0), CNS E14 (RPKM 41.9) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Zfta in Genome Data Viewer
Location:
19 A; 19 5.32 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (7394981..7403273)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (7417625..7425908)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RAB11B, member RAS oncogene family, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_45468 Neighboring gene predicted gene, 18842 Neighboring gene microRNA 6991 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:7520209-7520392 Neighboring gene reticulon 3 Neighboring gene atlastin GTPase 3 Neighboring gene phospholipase A and acyltransferase 3 Neighboring gene STARR-seq mESC enhancer starr_45469 Neighboring gene STARR-seq mESC enhancer starr_45470

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation. Ozawa T, et al. Acta Neuropathol Commun, 2021 Mar 8. PMID 33685520, Free PMC Article
  2. Ependymoma associated protein Zfta is expressed in immature ependymal cells but is not essential for ependymal development in mice. Herranz-Pérez V, et al. Sci Rep, 2022 Jan 27. PMID 35087169, Free PMC Article
  3. A genomic atlas of mouse hypothalamic development. Shimogori T, et al. Nat Neurosci, 2010 Jun. PMID 20436479, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation.
    Title: C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger translocation-associated protein
Names
uncharacterized protein C11orf95 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401803.1 → NP_001388732.1  zinc finger translocation-associated protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC129188

  2. NM_175381.7 → NP_780590.3  zinc finger translocation-associated protein isoform 1

    See identical proteins and their annotated locations for NP_780590.3

    Status: VALIDATED

    Source sequence(s)
    AC129188
    Consensus CDS
    CCDS29524.2
    UniProtKB/Swiss-Prot
    Q4VA45
    Related
    ENSMUSP00000123773.2, ENSMUST00000159348.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    7394981..7403273
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247115.3 → XP_011245417.1  zinc finger translocation-associated protein isoform X1

    Conserved Domains (1) summary
    pfam18658
    Location:638 → 705
    zf-C2H2_12; Zinc-finger C2H2-type
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4VA45.2 GenPept UniProtKB/Swiss-Prot:Q4VA45

Gene LinkOut

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