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Ankhd1 ankyrin repeat and KH domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 108857, updated on 21-Apr-2024

Summary

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Official Symbol
Ankhd1provided by MGI
Official Full Name
ankyrin repeat and KH domain containing 1provided by MGI
Primary source
MGI:MGI:1921733
See related
Ensembl:ENSMUSG00000024483 AllianceGenome:MGI:1921733
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mask; mFLJ00246; mKIAA1085; 1110004O12Rik; 4933432B13Rik; 9130019P20Rik; A530027J04Rik; A630021B20Rik
Summary
Predicted to be involved in innate immune response. Predicted to be active in cytoplasm. Is expressed in blastocyst; brain; and spinal cord. Orthologous to several human genes including ANKHD1-EIF4EBP3 (ANKHD1-EIF4EBP3 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 13.2), limb E14.5 (RPKM 11.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 B2; 18 19.46 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (36693656..36791961)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (36560603..36658908)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44290 Neighboring gene heparin-binding EGF-like growth factor Neighboring gene predicted gene, 41698 Neighboring gene solute carrier family 4, sodium bicarbonate cotransporter, member 9 Neighboring gene STARR-seq mESC enhancer starr_44296 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 4 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5653 Neighboring gene eukaryotic translation initiation factor 4E binding protein 3 Neighboring gene steroid receptor RNA activator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mask family proteins ANKHD1 and ANKRD17 regulate YAP nuclear import and stability. Sidor C, et al. Elife, 2019 Oct 29. PMID 31661072, Free PMC Article
  2. Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK. Poulin F, et al. J Biol Chem, 2003 Dec 26. PMID 14557257
  3. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
  4. Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling. Campbell GR, et al. Mol Cell Neurosci, 2011 Feb. PMID 21194568, Free PMC Article
  5. High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. Yoshikawa T, et al. Gene Expr Patterns, 2006 Jan. PMID 16325481, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough Maskbp3

Readthrough gene: Maskbp3, Included gene: Eif4ebp3

Homology

Clone Names

  • FLJ00246

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ankyrin repeat and KH domain-containing protein 1
Names
multiple ankyrin repeats, single KH-domain homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175375.3 → NP_780584.2  ankyrin repeat and KH domain-containing protein 1

    Status: VALIDATED

    Source sequence(s)
    AC115631, AK029322, AK042754, BC091647, BG804884, CD538664, CF742822, CJ165547
    Consensus CDS
    CCDS50256.1
    UniProtKB/TrEMBL
    E9PUR0, E9Q1M6
    Related
    ENSMUSP00000123270.3, ENSMUST00000155329.9
    Conserved Domains (7) summary
    cd00105
    Location:1696 → 1758
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd00204
    Location:370 → 494
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam05672
    Location:783 → 870
    MAP7; MAP7 (E-MAP-115) family
    pfam12796
    Location:279 → 368
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:377 → 428
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:409 → 438
    ANK; ANK repeat [structural motif]
    cl09111
    Location:817 → 855
    Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    36693656..36791961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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