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Mtrf1l mitochondrial translational release factor 1-like [ Mus musculus (house mouse) ]

Gene ID: 108853, updated on 5-Mar-2024

Summary

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Official Symbol
Mtrf1lprovided by MGI
Official Full Name
mitochondrial translational release factor 1-likeprovided by MGI
Primary source
MGI:MGI:1918830
See related
Ensembl:ENSMUSG00000019774 AllianceGenome:MGI:1918830
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9130004K12Rik
Summary
Predicted to enable translation release factor activity. Predicted to be involved in mitochondrial translational termination. Predicted to act upstream of or within translation. Located in mitochondrion. Orthologous to human MTRF1L (mitochondrial translation release factor 1 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 2.0), limb E14.5 (RPKM 1.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mtrf1l in Genome Data Viewer
Location:
10 A1; 10 1.91 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (5760151..5775015, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (5811119..5825015, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25595 Neighboring gene predicted gene, 30617 Neighboring gene STARR-positive B cell enhancer ABC_E3873 Neighboring gene STARR-positive B cell enhancer ABC_E3872 Neighboring gene predicted gene, 53609 Neighboring gene F-box protein 5 Neighboring gene STARR-seq mESC enhancer starr_25593 Neighboring gene regulator of G-protein signaling 17 Neighboring gene predicted gene, 18902 Neighboring gene STARR-seq mESC enhancer starr_25590 Neighboring gene STARR-seq mESC enhancer starr_25589 Neighboring gene STARR-seq mESC enhancer starr_25588 Neighboring gene STARR-seq mESC enhancer starr_25586 Neighboring gene predicted gene 3213

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables translation release factor activity ISO
Inferred from Sequence Orthology
more info
  
enables translation release factor activity, codon specific ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translational termination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial translational termination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational termination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peptide chain release factor 1-like, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175374.3 → NP_780583.1  peptide chain release factor 1-like, mitochondrial precursor

    See identical proteins and their annotated locations for NP_780583.1

    Status: VALIDATED

    Source sequence(s)
    AI510282, AK036424, AK078897
    Consensus CDS
    CCDS56684.1
    UniProtKB/Swiss-Prot
    Q8BJU9
    Related
    ENSMUSP00000019908.9, ENSMUST00000019908.9
    Conserved Domains (3) summary
    COG1186
    Location:123 → 355
    PrfB; Protein chain release factor B [Translation, ribosomal structure and biogenesis]
    pfam00472
    Location:224 → 329
    RF-1; RF-1 domain
    pfam03462
    Location:57 → 214
    PCRF; PCRF domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    5760151..5775015 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_380033.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BJU9.1 GenPept UniProtKB/Swiss-Prot:Q8BJU9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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