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Rdh13 retinol dehydrogenase 13 (all-trans and 9-cis) [ Mus musculus (house mouse) ]

Gene ID: 108841, updated on 11-Apr-2024

Summary

Official Symbol
Rdh13provided by MGI
Official Full Name
retinol dehydrogenase 13 (all-trans and 9-cis)provided by MGI
Primary source
MGI:MGI:1918732
See related
Ensembl:ENSMUSG00000008435 AllianceGenome:MGI:1918732
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
8430425D21Rik
Summary
Predicted to enable NADP-retinol dehydrogenase activity. Acts upstream of or within eye photoreceptor cell development; response to high light intensity; and retina layer formation. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human RDH13 (retinol dehydrogenase 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 8.9), whole brain E14.5 (RPKM 7.0) and 28 other tissues See more
Orthologs
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Genomic context

See Rdh13 in Genome Data Viewer
Location:
7 A1; 7 2.56 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4428664..4474279, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4425665..4471280, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene glycoprotein 6 platelet Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit C, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E1718 Neighboring gene STARR-positive B cell enhancer ABC_E9682 Neighboring gene RIKEN cDNA D630041G03 gene Neighboring gene EPS8-like 1 Neighboring gene protein phosphatase 1, regulatory subunit 12C Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:4461475-4461662 Neighboring gene troponin T1, skeletal, slow

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables all-trans-retinol dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables all-trans-retinol dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
retinol dehydrogenase 13
NP_001277338.1
NP_001277340.1
NP_780581.1
XP_011248714.1
XP_030097836.1
XP_030097837.1
XP_030097838.1
XP_030097839.1
XP_030097840.1
XP_030097841.1
XP_036008457.1
XP_036008458.1
XP_036008459.1
XP_036008460.1
XP_036008461.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290409.1NP_001277338.1  retinol dehydrogenase 13 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001277338.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC161218, AK034180, BY083213
    UniProtKB/TrEMBL
    A0A0R4J1N8
    Related
    ENSMUSP00000113433.2, ENSMUST00000119485.8
    Conserved Domains (2) summary
    PRK06197
    Location:32283
    PRK06197; short chain dehydrogenase; Provisional
    cl21454
    Location:38278
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_001290411.1NP_001277340.1  retinol dehydrogenase 13 isoform 3

    See identical proteins and their annotated locations for NP_001277340.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of the first exon and initiates translation at a downstream start codon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC161218, AK028434, BY083213, BY352329
    UniProtKB/Swiss-Prot
    Q8CEE7
    Conserved Domains (1) summary
    cl21454
    Location:1242
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. NM_175372.4NP_780581.1  retinol dehydrogenase 13 isoform 1 precursor

    See identical proteins and their annotated locations for NP_780581.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC161218, AK028434
    Consensus CDS
    CCDS20735.1
    UniProtKB/Swiss-Prot
    Q8CC07, Q8CEE7
    Related
    ENSMUSP00000008579.8, ENSMUST00000008579.14
    Conserved Domains (1) summary
    cl21454
    Location:38313
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    4428664..4474279 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250412.3XP_011248714.1  retinol dehydrogenase 13 isoform X2

    Conserved Domains (1) summary
    cl21454
    Location:18293
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. XM_036152564.1XP_036008457.1  retinol dehydrogenase 13 isoform X1

    UniProtKB/Swiss-Prot
    Q8CC07, Q8CEE7
    Conserved Domains (1) summary
    cl21454
    Location:38313
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. XM_030241979.1XP_030097839.1  retinol dehydrogenase 13 isoform X5

    Conserved Domains (1) summary
    cl21454
    Location:1207
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. XM_030241978.1XP_030097838.1  retinol dehydrogenase 13 isoform X4

    Conserved Domains (1) summary
    cl21454
    Location:1242
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  5. XM_030241981.1XP_030097841.1  retinol dehydrogenase 13 isoform X5

    Conserved Domains (1) summary
    cl21454
    Location:1207
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  6. XM_036152567.1XP_036008460.1  retinol dehydrogenase 13 isoform X4

    Conserved Domains (1) summary
    cl21454
    Location:1242
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  7. XM_036152568.1XP_036008461.1  retinol dehydrogenase 13 isoform X4

    Conserved Domains (1) summary
    cl21454
    Location:1242
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  8. XM_030241980.1XP_030097840.1  retinol dehydrogenase 13 isoform X5

    Conserved Domains (1) summary
    cl21454
    Location:1207
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  9. XM_030241976.1XP_030097836.1  retinol dehydrogenase 13 isoform X2

    Conserved Domains (1) summary
    cl21454
    Location:18293
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  10. XM_036152566.1XP_036008459.1  retinol dehydrogenase 13 isoform X4

    Conserved Domains (1) summary
    cl21454
    Location:1242
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  11. XM_036152565.1XP_036008458.1  retinol dehydrogenase 13 isoform X2

    Conserved Domains (1) summary
    cl21454
    Location:18293
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  12. XM_030241977.1XP_030097837.1  retinol dehydrogenase 13 isoform X3

    Conserved Domains (1) summary
    cl21454
    Location:18258
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins