U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Flacc1 flagellum associated containing coiled-coil domains 1 [ Mus musculus (house mouse) ]

Gene ID: 108812, updated on 8-Feb-2024

Summary

Go to the top of the page Help
Official Symbol
Flacc1provided by MGI
Official Full Name
flagellum associated containing coiled-coil domains 1provided by MGI
Primary source
MGI:MGI:1918359
See related
Ensembl:ENSMUSG00000047528 AllianceGenome:MGI:1918359
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Als2cr12; 4933405P16Rik; 4933425F06Rik
Summary
Located in cytoplasmic vesicle; outer dense fiber; and sperm fibrous sheath. Orthologous to human FLACC1 (flagellum associated containing coiled-coil domains 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 8.6), subcutaneous fat pad adult (RPKM 1.0) and 2 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1 C1.3; 1 29.15 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58696085..58735167, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58656926..58696008, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01018 Neighboring gene chromobox 3, pseudogene 7 Neighboring gene caspase 8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01019 Neighboring gene STARR-positive B cell enhancer mm9_chr1:58750575-58750876 Neighboring gene STARR-positive B cell enhancer ABC_E790 Neighboring gene STARR-positive B cell enhancer ABC_E5758 Neighboring gene CASP8 and FADD-like apoptosis regulator Neighboring gene STARR-seq mESC enhancer starr_01021 Neighboring gene STARR-seq mESC enhancer starr_01022 Neighboring gene STARR-positive B cell enhancer ABC_E1220 Neighboring gene STARR-seq mESC enhancer starr_01023 Neighboring gene predicted gene, 39646

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. FLACC1 is testis-specific but dispensable for fertility in mice. Chotiner JY, et al. Mol Reprod Dev, 2020 Dec. PMID 33156557, Free PMC Article
  2. Expression of a sperm flagellum component encoded by the Als2cr12 gene. Choi E, et al. Gene Expr Patterns, 2011 Jun-Jul. PMID 21402173
  3. Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library. Choi E, et al. BMC Genomics, 2007 Jul 28. PMID 17662146, Free PMC Article
  4. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FLACC1 is testis-specific but dispensable for fertility in mice.
    Title: FLACC1 is testis-specific but dispensable for fertility in mice.
  2. FLACC1 is dispensable for viability and fertility in mouse.
    Title: FLACC1 is testis-specific but dispensable for fertility in mice.
  3. the expression of the Als2cr12 gene at the transcriptional, protein and cellular levels.
    Title: Expression of a sperm flagellum component encoded by the Als2cr12 gene.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
flagellum-associated coiled-coil domain-containing protein 1
Names
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 12
amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein homolog
amyotrophic lateral sclerosis 2 chromosome region 12

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347056.1 → NP_001333985.1  flagellum-associated coiled-coil domain-containing protein 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC112968, AC118698
    Consensus CDS
    CCDS83544.1
    UniProtKB/TrEMBL
    A0A087WNN1
    Related
    ENSMUSP00000139420.2, ENSMUST00000191565.7
    Conserved Domains (1) summary
    TIGR02169
    Location:122 → 353
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  2. NM_175370.5 → NP_780579.1  flagellum-associated coiled-coil domain-containing protein 1 isoform b

    See identical proteins and their annotated locations for NP_780579.1

    Status: VALIDATED

    Source sequence(s)
    AK077190, AK133373
    Consensus CDS
    CCDS35581.1
    UniProtKB/Swiss-Prot
    Q8BVM7
    UniProtKB/TrEMBL
    A0A087WRU9
    Related
    ENSMUSP00000062497.8, ENSMUST00000055313.14
    Conserved Domains (1) summary
    TIGR02169
    Location:122 → 353
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    58696085..58735167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495613.4 → XP_006495676.1  flagellum-associated coiled-coil domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006495676.1

    UniProtKB/TrEMBL
    A0A087WNN1
    Conserved Domains (1) summary
    TIGR02169
    Location:122 → 353
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  2. XM_030255466.2 → XP_030111326.1  flagellum-associated coiled-coil domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A087WNN1
    Conserved Domains (1) summary
    TIGR02169
    Location:122 → 353
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  3. XM_006495618.5 → XP_006495681.1  flagellum-associated coiled-coil domain-containing protein 1 isoform X5

  4. XM_017321225.3 → XP_017176714.1  flagellum-associated coiled-coil domain-containing protein 1 isoform X3

    Conserved Domains (1) summary
    TIGR02168
    Location:38 → 263
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  5. XM_006495615.4 → XP_006495678.1  flagellum-associated coiled-coil domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A087WRU9
    Related
    ENSMUSP00000140780.2, ENSMUST00000188772.7
    Conserved Domains (1) summary
    TIGR02169
    Location:122 → 338
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  6. XM_006495617.3 → XP_006495680.1  flagellum-associated coiled-coil domain-containing protein 1 isoform X4

    Conserved Domains (1) summary
    PRK04863
    Location:180 → 244
    mukB; chromosome partition protein MukB

RNA

  1. XR_865219.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BVM7.1 GenPept UniProtKB/Swiss-Prot:Q8BVM7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous