U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Oxsr1 oxidative-stress responsive 1 [ Mus musculus (house mouse) ]

Gene ID: 108737, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Oxsr1provided by MGI
Official Full Name
oxidative-stress responsive 1provided by MGI
Primary source
MGI:MGI:1917378
See related
Ensembl:ENSMUSG00000036737 AllianceGenome:MGI:1917378
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Osr1; mKIAA1101; 2210022N24Rik; 2810422B09Rik
Summary
Enables protein serine/threonine kinase activity. Involved in several processes, including cellular hypotonic response; chemokine (C-C motif) ligand 21 signaling pathway; and positive regulation of T cell chemotaxis. Predicted to be located in cytosol. Is expressed in loop of Henle distal straight tubule and metanephros. Orthologous to human OXSR1 (oxidative stress responsive kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 9.9), CNS E11.5 (RPKM 9.8) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
9 F3; 9 71.33 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (119067498..119154475, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (119238432..119322684, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 (organic cation transporter), member 13 Neighboring gene STARR-seq mESC enhancer starr_25469 Neighboring gene solute carrier family 22 (organic cation transporter), member 13b Neighboring gene STARR-positive B cell enhancer ABC_E1119 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:119231914-119232305 Neighboring gene STARR-positive B cell enhancer ABC_E11425 Neighboring gene myeloid differentiation primary response gene 88 Neighboring gene acetyl-Coenzyme A acyltransferase 1A

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. OSR1-sensitive small intestinal Na+ transport. Pasham V, et al. Am J Physiol Gastrointest Liver Physiol, 2012 Dec 1. PMID 23019198
  2. OSR1-sensitive regulation of Na+/H+ exchanger activity in dendritic cells. Pasham V, et al. Am J Physiol Cell Physiol, 2012 Aug 15. PMID 22648948
  3. Regulation of NKCC2 activity by SPAK truncated isoforms. Gamba G. Am J Physiol Renal Physiol, 2014 Jan 1. PMID 24173353
  4. Role of the WNK-activated SPAK kinase in regulating blood pressure. Rafiqi FH, et al. EMBO Mol Med, 2010 Feb. PMID 20091762, Free PMC Article
  5. Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter. Gagnon KB, et al. Mol Cell Biol, 2006 Jan. PMID 16382158, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. circROCK1 Promotes septic myocardial injury through regulating miR-96-5p/OXSR1 axis.
    Title: circROCK1 Promotes septic myocardial injury through regulating miR-96-5p/OXSR1 axis.
  2. SPAK and OSR1 dependent down-regulation of murine renal outer medullary K channel ROMK1.
    Title: SPAK and OSR1 dependent down-regulation of murine renal outer medullary K channel ROMK1.
  3. Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses.
    Title: Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses.
  4. WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade.
    Title: WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade.
  5. Regulation of the Na+-Cl- cotransporter by dietary NaCl: a role for WNKs, SPAK, OSR1, and aldosterone.
    Title: Regulation of the Na+-Cl- cotransporter by dietary NaCl: a role for WNKs, SPAK, OSR1, and aldosterone.
  6. Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.
    Title: Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.
  7. Regulation of erythrocyte Na(+)/K(+)/2Cl(-) cotransport by an oxygen-switched kinase cascade.
    Title: Regulation of erythrocyte Na(+)/K(+)/2Cl(-) cotransport by an oxygen-switched kinase cascade.
  8. increased phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter in obesity and identifies a new role for AMP-activated protein kinase in regulating the activity of oxidative stress responsive 1 kinase-related proline-alanine-rich protein kinase
    Title: Novel mechanisms of Na+ retention in obesity: phosphorylation of NKCC2 and regulation of SPAK/OSR1 by AMPK.
  9. OSR1 is expressed in intestine and partial WNK insensitivity of OSR1 increases intestinal Na( )/H( ) exchanger activity and colonic epithelium Na( ) channel activity
    Title: OSR1-sensitive small intestinal Na+ transport.
  10. Data indicate that SPAK and OSR1 function interdependently in the distal convoluted tubule (DCT) to positively regulate thiazide-sensitive sodium-chloride cotransporter, NCC.
    Title: SPAK isoforms and OSR1 regulate sodium-chloride co-transporters in a nephron-specific manner.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell volume homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular hyperosmotic response ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular hypotonic response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular response to chemokine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to chemokine ISO
Inferred from Sequence Orthology
more info
  
involved_in chemokine (C-C motif) ligand 21 signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemokine (C-X-C motif) ligand 12 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of potassium ion transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of potassium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of potassium ion transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in osmosensory signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-threonine phosphorylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of T cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of T cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of T cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in renal sodium ion absorption ISO
Inferred from Sequence Orthology
more info
  
involved_in response to oxidative stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to xenobiotic stimulus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
serine/threonine-protein kinase OSR1
Names
oxidative stress-responsive 1 protein
NP_001346511.1
NP_598746.2
XP_030099862.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359582.1 → NP_001346511.1  serine/threonine-protein kinase OSR1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1 and 3 encode the same protein.
    Source sequence(s)
    AC128702
    Consensus CDS
    CCDS57714.1
    UniProtKB/Swiss-Prot
    Q6P9R2, Q8BVZ9, Q8C0B9
    UniProtKB/TrEMBL
    Q6ZPX7
    Conserved Domains (1) summary
    cd06610
    Location:15 → 291
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

  2. NM_133985.2 → NP_598746.2  serine/threonine-protein kinase OSR1

    See identical proteins and their annotated locations for NP_598746.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AC128702, BC060645
    Consensus CDS
    CCDS57714.1
    UniProtKB/Swiss-Prot
    Q6P9R2, Q8BVZ9, Q8C0B9
    UniProtKB/TrEMBL
    Q6ZPX7
    Related
    ENSMUSP00000042155.5, ENSMUST00000040853.11
    Conserved Domains (1) summary
    cd06610
    Location:15 → 291
    STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

RNA

  1. NR_045693.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC128702

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    119067498..119154475 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244002.2 → XP_030099862.1  serine/threonine-protein kinase OSR1 isoform X1

    Conserved Domains (2) summary
    pfam12202
    Location:242 → 299
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain
    cl21453
    Location:1 → 99
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P9R2.1 GenPept UniProtKB/Swiss-Prot:Q6P9R2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous