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Edem2 ER degradation enhancer, mannosidase alpha-like 2 [ Mus musculus (house mouse) ]

Gene ID: 108687, updated on 11-Apr-2024

Summary

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Official Symbol
Edem2provided by MGI
Official Full Name
ER degradation enhancer, mannosidase alpha-like 2provided by MGI
Primary source
MGI:MGI:1915540
See related
Ensembl:ENSMUSG00000038312 AllianceGenome:MGI:1915540
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9530090G24Rik
Summary
Predicted to enable calcium ion binding activity and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Involved in positive regulation of retrograde protein transport, ER to cytosol. Predicted to be located in endoplasmic reticulum. Orthologous to human EDEM2 (ER degradation enhancing alpha-mannosidase like protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 45.8), ovary adult (RPKM 41.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H1; 2 77.26 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155543593..155571395, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (155701673..155729475, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene myosin, heavy chain 7B, cardiac muscle, beta Neighboring gene microRNA 499 Neighboring gene transient receptor potential cation channel, subfamily C, member 4 associated protein Neighboring gene predicted gene, 22334 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:155505379-155505532 Neighboring gene STARR-positive B cell enhancer ABC_E10157 Neighboring gene STARR-seq mESC enhancer starr_06149 Neighboring gene protein C receptor, endothelial Neighboring gene matrix metallopeptidase 24 Neighboring gene predicted gene, 46772

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The role of EDEM2 compared with EDEM1 in ricin transport from the endoplasmic reticulum to the cytosol. Słomińska-Wojewódzka M, et al. Biochem J, 2014 Feb 1. PMID 24200403
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum mannose trimming IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mannoprotein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mannose trimming involved in glycoprotein ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of retrograde protein transport, ER to cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of retrograde protein transport, ER to cytosol ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ER degradation-enhancing alpha-mannosidase-like protein 2
NP_663512.2
XP_030102389.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145537.2 → NP_663512.2  ER degradation-enhancing alpha-mannosidase-like protein 2 precursor

    See identical proteins and their annotated locations for NP_663512.2

    Status: VALIDATED

    Source sequence(s)
    AK166998, AL929233, BY289191
    Consensus CDS
    CCDS16953.1
    UniProtKB/Swiss-Prot
    Q8BJR2, Q8BJT9, Q8BK85, Q91VV3
    Related
    ENSMUSP00000041202.5, ENSMUST00000040833.5
    Conserved Domains (1) summary
    pfam01532
    Location:42 → 480
    Glyco_hydro_47; Glycosyl hydrolase family 47

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    155543593..155571395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246529.2 → XP_030102389.1  ER degradation-enhancing alpha-mannosidase-like protein 2 isoform X1

    Conserved Domains (1) summary
    cl04955
    Location:3 → 204
    LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

RNA

  1. XR_866205.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BJT9.1 GenPept UniProtKB/Swiss-Prot:Q8BJT9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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