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Fam210a family with sequence similarity 210, member A [ Mus musculus (house mouse) ]

Gene ID: 108654, updated on 5-Mar-2024

Summary

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Official Symbol
Fam210aprovided by MGI
Official Full Name
family with sequence similarity 210, member Aprovided by MGI
Primary source
MGI:MGI:1914000
See related
Ensembl:ENSMUSG00000038121 AllianceGenome:MGI:1914000
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933403F05Rik
Summary
Located in mitochondrion. Orthologous to human FAM210A (family with sequence similarity 210 member A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 8.5), kidney adult (RPKM 5.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 E2; 18 40.98 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (68393248..68433404, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (68260175..68300333, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 4 Neighboring gene predicted gene, 52336 Neighboring gene VISTA enhancer mm304 Neighboring gene STARR-seq mESC enhancer starr_44925 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9174 Neighboring gene STARR-seq mESC enhancer starr_44926 Neighboring gene microRNA 7219 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:68459940-68460049 Neighboring gene STARR-seq mESC enhancer starr_44927 Neighboring gene RNA (guanine-7-) methyltransferase Neighboring gene melanocortin 5 receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Modulators of Fam210a and Roles of Fam210a in the Function of Myoblasts. Tanaka KI, et al. Calcif Tissue Int, 2020 May. PMID 31980842
  2. MicroRNA-574 regulates FAM210A expression and influences pathological cardiac remodeling. Wu J, et al. EMBO Mol Med, 2021 Feb 5. PMID 33369227, Free PMC Article
  3. FAM210A is a novel determinant of bone and muscle structure and strength. Tanaka KI, et al. Proc Natl Acad Sci U S A, 2018 Apr 17. PMID 29618611, Free PMC Article
  4. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
  5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FAM210A regulates mitochondrial translation and maintains cardiac mitochondrial homeostasis.
    Title: FAM210A regulates mitochondrial translation and maintains cardiac mitochondrial homeostasis.
  2. FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes.
    Title: FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes.
  3. MicroRNA-574 regulates FAM210A expression and influences pathological cardiac remodeling.
    Title: MicroRNA-574 regulates FAM210A expression and influences pathological cardiac remodeling.
  4. Modulators of Fam210a and Roles of Fam210a in the Function of Myoblasts.
    Title: Modulators of Fam210a and Roles of Fam210a in the Function of Myoblasts.
  5. Fam210a was expressed in muscle mitochondria and cytoplasm but not in bone. Nevertheless, in genetically modified mouse models, Fam210a strongly influenced the structure and strength of both muscle and bone.
    Title: FAM210A is a novel determinant of bone and muscle structure and strength.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC48232

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein FAM210A
Names
uncharacterized protein C18orf19 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153794.4 → NP_722489.1  protein FAM210A

    See identical proteins and their annotated locations for NP_722489.1

    Status: VALIDATED

    Source sequence(s)
    AC111069, AK077093, AK147662, BQ176997
    Consensus CDS
    CCDS29326.1
    UniProtKB/Swiss-Prot
    Q3TXD0, Q8BGY7, Q8BNY5
    Related
    ENSMUSP00000045927.7, ENSMUST00000042852.7
    Conserved Domains (2) summary
    pfam05178
    Location:230 → 270
    Kri1; KRI1-like family
    pfam06916
    Location:125 → 212
    DUF1279; Protein of unknown function (DUF1279)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    68393248..68433404 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525524.5 → XP_006525587.1  protein FAM210A isoform X1

    See identical proteins and their annotated locations for XP_006525587.1

    UniProtKB/Swiss-Prot
    Q3TXD0, Q8BGY7, Q8BNY5
    Conserved Domains (2) summary
    pfam05178
    Location:230 → 270
    Kri1; KRI1-like family
    pfam06916
    Location:125 → 212
    DUF1279; Protein of unknown function (DUF1279)

  2. XM_030250272.2 → XP_030106132.1  protein FAM210A isoform X1

    UniProtKB/Swiss-Prot
    Q3TXD0, Q8BGY7, Q8BNY5
    Conserved Domains (2) summary
    pfam05178
    Location:230 → 270
    Kri1; KRI1-like family
    pfam06916
    Location:125 → 212
    DUF1279; Protein of unknown function (DUF1279)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGY7.1 GenPept UniProtKB/Swiss-Prot:Q8BGY7

Gene LinkOut

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