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Mat2b methionine adenosyltransferase 2 non-catalytic beta subunit methionine [ Mus musculus (house mouse) ]

Gene ID: 108645, updated on 16-Apr-2024

Summary

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Official Symbol
Mat2bprovided by MGI
Official Full Name
methionine adenosyltransferase 2 non-catalytic beta subunit methionineprovided by MGI
Primary source
MGI:MGI:1913667
See related
Ensembl:ENSMUSG00000042032 AllianceGenome:MGI:1913667
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TGR; MAT-II; MATIIbeta; 1110064C04Rik; 2410018D16Rik
Summary
Predicted to enable enzyme binding activity and methionine adenosyltransferase regulator activity. Predicted to be involved in S-adenosylmethionine biosynthetic process. Predicted to act upstream of or within one-carbon metabolic process. Located in mitochondrion. Is expressed in several structures, including brain; genitourinary system; limb; nose; and respiratory system. Orthologous to human MAT2B (methionine adenosyltransferase 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 34.1), bladder adult (RPKM 28.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A5; 11 24.4 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (40570141..40586030, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (40679314..40695203, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29228 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene Neighboring gene aldo-keto reductase family 1, member B3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6966 Neighboring gene hyaluronan mediated motility receptor (RHAMM) Neighboring gene STARR-seq mESC enhancer starr_29231 Neighboring gene STARR-seq mESC enhancer starr_29232 Neighboring gene NudC domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Methionine Adenosyltransferase 2β Participates in Mouse Oocyte Maturation by Regulating the MAPK Pathway. An Q, et al. Reprod Sci, 2020 Jan. PMID 32046373
  2. Increased miR-21-3p in Injured Brain Microvascular Endothelial Cells after Traumatic Brain Injury Aggravates Blood-Brain Barrier Damage by Promoting Cellular Apoptosis and Inflammation through Targeting MAT2B. Ge X, et al. J Neurotrauma, 2019 Apr 15. PMID 29695199
  3. Methionine adenosyltransferase 2A regulates mouse zygotic genome activation and morula to blastocyst transition†. Sun H, et al. Biol Reprod, 2019 Mar 1. PMID 30265288
  4. Cloning, expression, and functional characterization of the beta regulatory subunit of human methionine adenosyltransferase (MAT II). LeGros HL Jr, et al. J Biol Chem, 2000 Jan 28. PMID 10644686
  5. Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated with plasma hyperhomocysteinemia. Partearroyo T, et al. FASEB J, 2019 May. PMID 30753104, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Methionine Adenosyltransferase 2beta Participates in Mouse Oocyte Maturation by Regulating the MAPK Pathway.
    Title: Methionine Adenosyltransferase 2β Participates in Mouse Oocyte Maturation by Regulating the MAPK Pathway.
  2. Increased miR-21-3p in Injured Brain Microvascular Endothelial Cells after Traumatic Brain Injury Aggravates Blood-Brain Barrier Damage by Promoting Cellular Apoptosis and Inflammation through Targeting MAT2B.
    Title: Increased miR-21-3p in Injured Brain Microvascular Endothelial Cells after Traumatic Brain Injury Aggravates Blood-Brain Barrier Damage by Promoting Cellular Apoptosis and Inflammation through Targeting MAT2B.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables methionine adenosyltransferase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methionine adenosyltransferase regulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in S-adenosylmethionine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in S-adenosylmethionine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of methionine adenosyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of methionine adenosyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
methionine adenosyltransferase 2 subunit beta
Names
MAT II beta
methionine adenosyltransferase 2 beta subunit
methionine adenosyltransferase II, beta
NP_001186203.1
NP_598778.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199274.1 → NP_001186203.1  methionine adenosyltransferase 2 subunit beta isoform 2

    See identical proteins and their annotated locations for NP_001186203.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate first exon which includes different sequence for the 5' coding region, compared to variant 1. The resulting protein (isoform 2) has a distinct and shorter N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AK075947, BC003457, CA559663
    Consensus CDS
    CCDS56767.1
    UniProtKB/Swiss-Prot
    Q99LB6
    Related
    ENSMUSP00000098901.4, ENSMUST00000101347.10
    Conserved Domains (2) summary
    cd05254
    Location:19 → 305
    dTDP_HR_like_SDR_e; dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs
    pfam04321
    Location:20 → 311
    RmlD_sub_bind; RmlD substrate binding domain

  2. NM_134017.2 → NP_598778.1  methionine adenosyltransferase 2 subunit beta isoform 1

    See identical proteins and their annotated locations for NP_598778.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform a).
    Source sequence(s)
    AL646055, BC003457
    Consensus CDS
    CCDS24547.1
    UniProtKB/Swiss-Prot
    Q5NC89, Q76LX2, Q8BVX6, Q8BYT9, Q99LB6
    Related
    ENSMUSP00000048222.5, ENSMUST00000040167.11
    Conserved Domains (2) summary
    cd05254
    Location:30 → 316
    dTDP_HR_like_SDR_e; dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs
    pfam04321
    Location:31 → 322
    RmlD_sub_bind; RmlD substrate binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    40570141..40586030 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99LB6.1 GenPept UniProtKB/Swiss-Prot:Q99LB6

Gene LinkOut

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