LINP1 lncRNA in non-homologous end joining pathway 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LINP1provided by HGNC
Official Full Name: lncRNA in non-homologous end joining pathway 1provided by HGNC
Primary source: HGNC:HGNC:53170
See related: AllianceGenome:HGNC:53170
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PARROT
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Genomic context

Location:: 10p14

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (6737382..6738939)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (6737620..6739177)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (6779344..6780901)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA LINP1 confers tamoxifen resistance and negatively regulated by ER signaling in breast cancer.
Title: LncRNA LINP1 confers tamoxifen resistance and negatively regulated by ER signaling in breast cancer.
STAT1-induced upregulation of lncRNA LINP1 promotes cell proliferation and inhibits apoptosis via AMPK signaling pathway in papillary thyroid cancer.
Title: STAT1-induced upregulation of lncRNA LINP1 promotes cell proliferation and inhibits apoptosis via AMPK signaling pathway in papillary thyroid cancer.
LINP1 promotes the progression of cervical cancer by scaffolding EZH2, LSD1, and DNMT1 to inhibit the expression of KLF2 and PRSS8.
Title: LINP1 promotes the progression of cervical cancer by scaffolding EZH2, LSD1, and DNMT1 to inhibit the expression of KLF2 and PRSS8.
LncRNA LINP1 promotes malignant progression of pancreatic cancer by adsorbing microRNA-491-3p.
Title: LncRNA LINP1 promotes malignant progression of pancreatic cancer by adsorbing microRNA-491-3p.
LncRNA-AK149641 regulates the secretion of tumor necrosis factor-alpha in P815 mast cells by targeting the nuclear factor-kappa B signaling pathway.
Title: LncRNA-AK149641 regulates the secretion of tumor necrosis factor-α in P815 mast cells by targeting the nuclear factor-kappa B signaling pathway.
Mechanism of efficient double-strand break repair by a long non-coding RNA.
Title: Mechanism of efficient double-strand break repair by a long non-coding RNA.
Long non-coding RNA LINP1 functions as an oncogene in endometrial cancer progression by regulating the PI3K/AKT signaling pathway.
Title: Long non-coding RNA LINP1 functions as an oncogene in endometrial cancer progression by regulating the PI3K/AKT signaling pathway.
LINP1 appeared to have higher expression in breast cancer tissues than in adjacent non-tumor tissues. Increased expression of LINP1 was correlated with advanced TNM stage, more lymph node metastasis, and poorer pathological differentiation. Furthermore, clinical assay indicated that patients with high LINP1 expression had a shorter overall survival and disease-free survival compared with the low LINP1 expression group.
Title: Increased long noncoding RNA LINP1 expression and its prognostic significance in human breast cancer.
LINP1 was found to inhibit the glucose metabolism by suppressing the expression of HNF4a. LINP1 strengthened the HNF4a-AMPK/WNT5A signaling pathway involved in cell glucose metabolism modulation and AML cell survival. LINP1 promotes the malignant phenotype of AML cells and stimulates glucose metabolism.
Title: LncRNA LINP1 regulates acute myeloid leukemia progression via HNF4α/AMPK/WNT5A signaling pathway.
LINP1 facilitates DSBs repair through NHEJ pathway and may thus serve as a prognostic marker and a potential target for the therapy of cervical cancer. LINP1 knockdown increases radiosensitivity of Hela S3 cells.
Title: LINP1 facilitates DNA damage repair through non-homologous end joining (NHEJ) pathway and subsequently decreases the sensitivity of cervical cancer cells to ionizing radiation.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Variation

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General gene information

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Other Names

Proliferation Associated RNA and Regulator Of Translation
lncRNA in nonhomologous end joining (NHEJ) pathway 1
lncRNA in nonhomologous end joining pathway 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.