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LOC108444576 Nr0b1 5' regulatory region [ Mus musculus (house mouse) ]

Gene ID: 108444576, updated on 14-Mar-2024

Summary

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Gene symbol
LOC108444576
Gene description
Nr0b1 5' regulatory region
Gene type
biological region
Feature type(s)
misc_feature: conserved_region
protein_bind
regulatory: TATA_box, enhancer, promoter, transcriptional_cis_regulatory_region
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rr366705
Summary
This region encompasses 5' regulatory elements of the Nr0b1 (nuclear receptor subfamily 0 group B member 1, also known as Dax1) gene. It includes the proximal promoter as well as an upstream enhancer that drives expression in the developing gonads. Binding of Nr5a1/Sf1 (nuclear receptor subfamily 5 group A member 1), Wilms tumor 1, and lymphoid enhancer binding factor 1, among other factors, stimulates activity of this sequence. This locus also includes an enhancer that was validated by the STARR-seq (self-transcribing active regulatory region sequencing) reporter assay in ground-state (2iL) mouse embryonic stem cells, where it was defined as a C1 class enhancer that overlaps an active chromatin signature. [provided by RefSeq, Jul 2023]
Orthologs
human all
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Genomic context

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Location:
chromosome: X
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (85230648..85235410)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (86187128..86191804)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 54063 Neighboring gene STARR-seq mESC enhancer starr_47497 Neighboring gene spermatogenesis associated multipass transmembrane protein 3 Neighboring gene STARR-seq mESC enhancer starr_47498 Neighboring gene Nr0b1 intronic regulatory region Neighboring gene nuclear receptor subfamily 0, group B, member 1 Neighboring gene MAGE family member B4 Neighboring gene phosphoenolpyruvate carboxykinase 2 (mitochondrial) pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reciprocal regulation of a glucocorticoid receptor-steroidogenic factor-1 transcription complex on the Dax-1 promoter by glucocorticoids and adrenocorticotropic hormone in the adrenal cortex. Gummow BM, et al. Mol Endocrinol, 2006 Nov. PMID 16857744
  2. The Wilms' tumor suppressor gene (wt1) product regulates Dax-1 gene expression during gonadal differentiation. Kim J, et al. Mol Cell Biol, 1999 Mar. PMID 10022915, Free PMC Article
  3. The murine Dax-1 promoter is stimulated by SF-1 (steroidogenic factor-1) and inhibited by COUP-TF (chicken ovalbumin upstream promoter-transcription factor) via a composite nuclear receptor-regulatory element. Yu RN, et al. Mol Endocrinol, 1998 Jul. PMID 9658405
  4. Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: potential links in endocrine development. Ikeda Y, et al. Mol Endocrinol, 1996 Oct. PMID 9121493
  5. Mouse Dax1 expression is consistent with a role in sex determination as well as in adrenal and hypothalamus function. Swain A, et al. Nat Genet, 1996 Apr. PMID 8630494

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Other Names

  • STARR-seq mESC enhancer starr_47499
  • regulatory region 366705

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051301.2 

    Range
    101..4863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    85230648..85235410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version