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ZNF275 zinc finger protein 275 [ Homo sapiens (human) ]

Gene ID: 10838, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF275provided by HGNC
Official Full Name
zinc finger protein 275provided by HGNC
Primary source
HGNC:HGNC:13069
See related
Ensembl:ENSG00000063587 AllianceGenome:HGNC:13069
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a zinc finger protein that appears to be conserved in eutheria. Its function has not yet been established. [provided by RefSeq, Jul 2010]
Expression
Broad expression in adrenal (RPKM 38.8), ovary (RPKM 27.3) and 24 other tissues See more
Orthologs
all
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Genomic context

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See ZNF275 in Genome Data Viewer
Location:
Xq28
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (153334153..153352926)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (151601682..151620455)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (152599611..152618384)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene PWWP domain containing 4 Neighboring gene PNMA family member 6F Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21059 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21060 Neighboring gene Sharpr-MPRA regulatory region 13180 Neighboring gene microRNA 12129 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:152612756-152613256 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC105373378 Neighboring gene uncharacterized LOC105373379 Neighboring gene PNMA family member 6E Neighboring gene RNA, 7SL, cytoplasmic 667, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21062 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:152677238-152677448 Neighboring gene ZFP92 zinc finger protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Comparative genome sequence analysis of the Bpa/Str region in mouse and Man. Mallon AM, et al. Genome Res, 2000 Jun. PMID 10854409, Free PMC Article
  2. UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair. Huang Q, et al. FASEB J, 2022 Jan. PMID 34921745
  3. N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cheng Y, et al. Cancer Cell, 2021 Jul 12. PMID 34048709, Free PMC Article
  4. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article
  5. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 275

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021432.2 RefSeqGene

    Range
    4999..23772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001080485.4 → NP_001073954.3  zinc finger protein 275 isoform 2

    See identical proteins and their annotated locations for NP_001073954.3

    Status: VALIDATED

    Source sequence(s)
    AC152007, AC152008, AK122976
    Consensus CDS
    CCDS48188.2
    UniProtKB/TrEMBL
    A6NFS0
    Related
    ENSP00000359271.2, ENST00000370251.3
    Conserved Domains (5) summary
    COG5048
    Location:207 → 273
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:183 → 203
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:103 → 123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:295 → 315
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:196 → 219
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001367757.1 → NP_001354686.1  zinc finger protein 275 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC152007, AC152008, BX280482, DA249563, HY052974
    Consensus CDS
    CCDS94693.1
    UniProtKB/Swiss-Prot
    A6NE92, Q9NSD4
    Related
    ENSP00000496975.2, ENST00000650114.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    153334153..153352926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    151601682..151620455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_020636.2: Suppressed sequence

    Description
    NM_020636.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NSD4.2 GenPept UniProtKB/Swiss-Prot:Q9NSD4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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