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Galnt7 polypeptide N-acetylgalactosaminyltransferase 7 [ Mus musculus (house mouse) ]

Gene ID: 108150, updated on 11-Apr-2024

Summary

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Official Symbol
Galnt7provided by MGI
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 7provided by MGI
Primary source
MGI:MGI:1349449
See related
Ensembl:ENSMUSG00000031608 AllianceGenome:MGI:1349449
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables polypeptide N-acetylgalactosaminyltransferase activity. Acts upstream of or within protein O-linked glycosylation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and urinary system. Orthologous to human GALNT7 (polypeptide N-acetylgalactosaminyltransferase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 6.3), placenta adult (RPKM 5.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 B2; 8 29.92 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (57976859..58106089, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (57523825..57653055, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2500002B13 gene Neighboring gene STARR-seq mESC enhancer starr_21528 Neighboring gene STARR-positive B cell enhancer ABC_E1755 Neighboring gene STARR-seq mESC enhancer starr_21531 Neighboring gene STARR-seq mESC enhancer starr_21533 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:60058653-60058919 Neighboring gene predicted gene 6012 Neighboring gene predicted gene, 51574 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 25379 Neighboring gene high mobility group box 2 Neighboring gene expressed sequence AW046200 Neighboring gene STARR-seq mESC enhancer starr_21537 Neighboring gene STARR-seq mESC enhancer starr_21540 Neighboring gene STARR-positive B cell enhancer ABC_E5007 Neighboring gene UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6 Neighboring gene STARR-seq mESC enhancer starr_21544 Neighboring gene predicted gene 2921 Neighboring gene STARR-seq mESC enhancer starr_21547 Neighboring gene predicted gene 15881

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of a UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase that displays glycopeptide N-acetylgalactosaminyltransferase activity. Ten Hagen KG, et al. J Biol Chem, 1999 Sep 24. PMID 10488133
  2. MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7. Kahai S, et al. PLoS One, 2009 Oct 21. PMID 19844573, Free PMC Article
  3. Cloning and characterization of a ninth member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, ppGaNTase-T9. Ten Hagen KG, et al. J Biol Chem, 2001 May 18. PMID 11278534
  4. Diverse spatial expression patterns of UDP-GalNAc:polypeptide N-acetylgalactosaminyl-transferase family member mRNAs during mouse development. Kingsley PD, et al. Glycobiology, 2000 Dec. PMID 11159923
  5. miR-30 family microRNAs regulate myogenic differentiation and provide negative feedback on the microRNA pathway. Guess MG, et al. PLoS One, 2015. PMID 25689854, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7
    Title: MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein O-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
N-acetylgalactosaminyltransferase 7
Names
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
galNAc-T7
polypeptide GalNAc transferase 7
pp-GaNTase 7
ppGaNTase-T7
protein-UDP acetylgalactosaminyltransferase 7
NP_001161453.1
NP_653332.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167981.1 → NP_001161453.1  N-acetylgalactosaminyltransferase 7 isoform 2

    See identical proteins and their annotated locations for NP_001161453.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame exon and lacks an alternate in-frame exon, compared to variant 1, and encodes isoform 2. Variants 1 and 2 encode proteins of identical length but use different exons to encode aa 323-383.
    Source sequence(s)
    AK033427, AK036523, AK152205, BY167413, CB524213
    Consensus CDS
    CCDS52552.1
    UniProtKB/TrEMBL
    Q3U9K4
    Related
    ENSMUSP00000105945.3, ENSMUST00000110316.3
    Conserved Domains (4) summary
    cd02510
    Location:210 → 518
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    COG1215
    Location:210 → 438
    BcsA; Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility]
    cd00161
    Location:535 → 651
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:534 → 649
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  2. NM_144731.4 → NP_653332.3  N-acetylgalactosaminyltransferase 7 isoform 1

    See identical proteins and their annotated locations for NP_653332.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1. Variants 1 and 2 encode proteins of identical length but use different exons to encode aa 323-383.
    Source sequence(s)
    AF349573, AK033427, AK152205, BY167413, CB524213
    Consensus CDS
    CCDS22317.1
    UniProtKB/Swiss-Prot
    Q80VA0, Q8BY62, Q8BZ70, Q8BZW0, Q91VW6, Q99MD7
    UniProtKB/TrEMBL
    Q3U9K4
    Related
    ENSMUSP00000034021.5, ENSMUST00000034021.12
    Conserved Domains (4) summary
    cd02510
    Location:210 → 518
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    COG0463
    Location:210 → 444
    WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
    cd00161
    Location:535 → 651
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:534 → 649
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    57976859..58106089 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80VA0.2 GenPept UniProtKB/Swiss-Prot:Q80VA0

Gene LinkOut

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