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Slco3a1 solute carrier organic anion transporter family, member 3a1 [ Mus musculus (house mouse) ]

Gene ID: 108116, updated on 17-Mar-2024

Summary

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Official Symbol
Slco3a1provided by MGI
Official Full Name
solute carrier organic anion transporter family, member 3a1provided by MGI
Primary source
MGI:MGI:1351867
See related
Ensembl:ENSMUSG00000025790 AllianceGenome:MGI:1351867
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Anr1; MJAM; OATP-D; Slc21a11; 5830414C08Rik
Summary
Predicted to enable oligopeptide transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in organic anion transport; positive regulation of NF-kappaB transcription factor activity; and positive regulation of protein phosphorylation. Predicted to act upstream of or within oligopeptide transport and organic anion transport. Predicted to be located in apical plasma membrane; basal plasma membrane; and cell surface. Predicted to be integral component of plasma membrane. Is expressed in nervous system and thyroid gland. Orthologous to human SLCO3A1 (solute carrier organic anion transporter family member 3A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 34.1), ovary adult (RPKM 22.9) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Slco3a1 in Genome Data Viewer
Location:
7 42.95 cM; 7 D1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (73925166..74204528, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (74275418..74554780, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 Neighboring gene STARR-seq mESC enhancer starr_19204 Neighboring gene STARR-seq mESC enhancer starr_19205 Neighboring gene alpha-enolase pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:81486370-81486479 Neighboring gene STARR-seq mESC enhancer starr_19206 Neighboring gene STARR-seq mESC enhancer starr_19207 Neighboring gene predicted gene, 53360 Neighboring gene predicted gene, 39037

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of androgen-regulated genes in mouse kidney by representational difference analysis and random arbitrarily primed polymerase chain reaction. Melià MJ, et al. Endocrinology, 1998 Feb. PMID 9449642
  2. Solute Carrier Organic Anion Transporter Family Member 3A1 Is a Bile Acid Efflux Transporter in Cholestasis. Pan Q, et al. Gastroenterology, 2018 Nov. PMID 30063921, Free PMC Article
  3. Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion. Di Cosmo C, et al. J Clin Invest, 2010 Sep. PMID 20679730, Free PMC Article
  4. Weight loss after gastric bypass is associated with a variant at 15q26.1. Hatoum IJ, et al. Am J Hum Genet, 2013 May 2. PMID 23643386, Free PMC Article
  5. Molecular physiology of renal organic anion transporters. Sekine T, et al. Am J Physiol Renal Physiol, 2006 Feb. PMID 16403838

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of DNMT1 Induces SLCO3A1 to Promote Follicular Growth by Enhancing the Proliferation of Granulosa Cells in Mammals.
    Title: Knockdown of DNMT1 Induces SLCO3A1 to Promote Follicular Growth by Enhancing the Proliferation of Granulosa Cells in Mammals.
  2. Expression of St8sia2 and Slco3a1 was significantly altered in metabolically active tissues in Roux-en-Y gastric bypass-treated compared to weight-matched, sham-operated mice.
    Title: Weight loss after gastric bypass is associated with a variant at 15q26.1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables prostaglandin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium-independent organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in prostaglandin transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in prostaglandin transport ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
solute carrier organic anion transporter family member 3A1
Names
androgen regulated protein 1
organic anion-transporting polypeptide D
sodium-independent organic anion transporter D
solute carrier family 21 (organic anion transporter), member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038643.1 → NP_001033732.1  solute carrier organic anion transporter family member 3A1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes a 3' terminal exon that extends past a splice site used in variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC114591, AK031280, AK037938
    Consensus CDS
    CCDS21366.1
    UniProtKB/TrEMBL
    D3YXA8
    Related
    ENSMUSP00000095973.3, ENSMUST00000098371.9
    Conserved Domains (1) summary
    cd17402
    Location:39 → 563
    MFS_SLCO3_OATP3; Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters

  2. NM_023908.2 → NP_076397.2  solute carrier organic anion transporter family member 3A1 isoform 1

    See identical proteins and their annotated locations for NP_076397.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AK031280, AK046945, AK152488
    Consensus CDS
    CCDS21367.1
    UniProtKB/Swiss-Prot
    Q3TLX2, Q3U7W0, Q505P2, Q544H3, Q8R3L5, Q9CTV3, Q9JKV0
    UniProtKB/TrEMBL
    D3YXA8
    Related
    ENSMUSP00000026897.8, ENSMUST00000026897.14
    Conserved Domains (1) summary
    cd17402
    Location:39 → 563
    MFS_SLCO3_OATP3; Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    73925166..74204528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R3L5.1 GenPept UniProtKB/Swiss-Prot:Q8R3L5

Gene LinkOut

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