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Slco4a1 solute carrier organic anion transporter family, member 4a1 [ Mus musculus (house mouse) ]

Gene ID: 108115, updated on 5-Mar-2024

Summary

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Official Symbol
Slco4a1provided by MGI
Official Full Name
solute carrier organic anion transporter family, member 4a1provided by MGI
Primary source
MGI:MGI:1351866
See related
Ensembl:ENSMUSG00000038963 AllianceGenome:MGI:1351866
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OATP-E; Slc21a12
Summary
Predicted to enable sodium-independent organic anion transmembrane transporter activity and thyroid hormone transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport and thyroid hormone metabolic process. Predicted to act upstream of or within organic anion transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in central nervous system; hippocampus; retina inner nuclear layer; retina layer; and retina outer nuclear layer. Orthologous to human SLCO4A1 (solute carrier organic anion transporter family member 4A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 15.2), genital fat pad adult (RPKM 12.7) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H4; 2 102.99 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180098019..180116646)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180456226..180474853)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Mir1a-1 and Mir133a-2 host gene Neighboring gene microRNA 1a-1 Neighboring gene microRNA 133a-2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:180171931-180172146 Neighboring gene STARR-positive B cell enhancer mm9_chr2:180178418-180178718 Neighboring gene STARR-seq mESC enhancer starr_06732 Neighboring gene neurotensin receptor 1 Neighboring gene predicted gene, 30144 Neighboring gene STARR-positive B cell enhancer ABC_E9543 Neighboring gene MRG/MORF4L binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Solute carrier organic anion transporter family member 4A1 promotes colorectal cancer progression and is regulated by miR-1224-5p. Jiang Y, et al. Neoplasma, 2022 Jul. PMID 35331000
  2. Developmental and cell type-specific expression of thyroid hormone transporters in the mouse brain and in primary brain cells. Braun D, et al. Glia, 2011 Mar. PMID 21264952
  3. Molecular physiology of renal organic anion transporters. Sekine T, et al. Am J Physiol Renal Physiol, 2006 Feb. PMID 16403838
  4. Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome. Wirth EK, et al. J Neurosci, 2009 Jul 29. PMID 19641107, Free PMC Article
  5. Maternal bile acid transporter deficiency promotes neonatal demise. Zhang Y, et al. Nat Commun, 2015 Sep 29. PMID 26416771, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Solute carrier organic anion transporter family member 4A1 promotes colorectal cancer progression and is regulated by miR-1224-5p.
    Title: Solute carrier organic anion transporter family member 4A1 promotes colorectal cancer progression and is regulated by miR-1224-5p.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC28799, MGC28824

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables prostaglandin transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium-independent organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thyroid hormone transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thyroid hormone transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thyroid hormone metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier organic anion transporter family member 4A1
Names
organic anion-transporting polypeptide E
sodium-independent organic anion transporter E
solute carrier family 21 (organic anion transporter), member 12
solute carrier family 21 member 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355218.1 → NP_001342147.1  solute carrier organic anion transporter family member 4A1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK033598, AL669926
    Consensus CDS
    CCDS17176.1
    UniProtKB/Swiss-Prot
    Q8BZT4, Q8K078
    Related
    ENSMUSP00000046502.7, ENSMUST00000038259.13
    Conserved Domains (1) summary
    pfam03137
    Location:103 → 665
    OATP; Organic Anion Transporter Polypeptide (OATP) family

  2. NM_148933.1 → NP_683735.1  solute carrier organic anion transporter family member 4A1

    See identical proteins and their annotated locations for NP_683735.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BC030719
    Consensus CDS
    CCDS17176.1
    UniProtKB/Swiss-Prot
    Q8BZT4, Q8K078
    Related
    ENSMUSP00000045023.8, ENSMUST00000038225.8
    Conserved Domains (1) summary
    pfam03137
    Location:103 → 665
    OATP; Organic Anion Transporter Polypeptide (OATP) family

RNA

  1. NR_149314.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' end, contains an alternate internal exon, and lacks another alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL669926

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    180098019..180116646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157372.1 → XP_036013265.1  solute carrier organic anion transporter family member 4A1 isoform X2

    Related
    ENSMUST00000139902.8
    Conserved Domains (1) summary
    cl28910
    Location:5 → 313
    MFS; Major Facilitator Superfamily

  2. XM_036157366.1 → XP_036013259.1  solute carrier organic anion transporter family member 4A1 isoform X1

    Conserved Domains (1) summary
    cl28910
    Location:11 → 318
    MFS; Major Facilitator Superfamily

  3. XM_036157369.1 → XP_036013262.1  solute carrier organic anion transporter family member 4A1 isoform X2

    Conserved Domains (1) summary
    cl28910
    Location:5 → 313
    MFS; Major Facilitator Superfamily

  4. XM_036157367.1 → XP_036013260.1  solute carrier organic anion transporter family member 4A1 isoform X1

    Conserved Domains (1) summary
    cl28910
    Location:11 → 318
    MFS; Major Facilitator Superfamily

RNA

  1. XR_003949978.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K078.2 GenPept UniProtKB/Swiss-Prot:Q8K078

Gene LinkOut

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