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Slco1a5 solute carrier organic anion transporter family, member 1a5 [ Mus musculus (house mouse) ]

Gene ID: 108096, updated on 8-Feb-2024

Summary

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Official Symbol
Slco1a5provided by MGI
Official Full Name
solute carrier organic anion transporter family, member 1a5provided by MGI
Primary source
MGI:MGI:1351865
See related
Ensembl:ENSMUSG00000063975 AllianceGenome:MGI:1351865
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Oatp3; Oatp-3; Slc21a7
Summary
Predicted to enable bile acid transmembrane transporter activity; sodium-independent organic anion transmembrane transporter activity; and thyroid hormone transmembrane transporter activity. Predicted to be involved in bile acid and bile salt transport; intestinal absorption; and sodium-independent organic anion transport. Predicted to act upstream of or within ion transport. Predicted to be located in brush border membrane. Predicted to be integral component of plasma membrane. Is expressed in ear; nervous system; and thyroid gland. Orthologous to human SLCO1A2 (solute carrier organic anion transporter family member 1A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 1.3), liver adult (RPKM 0.4) and 9 other tissues See more
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Genomic context

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See Slco1a5 in Genome Data Viewer
Location:
6 G2; 6 73.69 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (142179953..142268707, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (142234227..142322981, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family, member 1a8 Neighboring gene STARR-seq mESC enhancer starr_17699 Neighboring gene solute carrier organic anion transporter family, member 1a6 Neighboring gene STARR-seq mESC enhancer starr_17700 Neighboring gene predicted gene, 18159 Neighboring gene STARR-seq mESC enhancer starr_17701 Neighboring gene predicted gene, 53313 Neighboring gene STARR-seq mESC enhancer starr_17703 Neighboring gene 60S ribosomal protein L18 pseudogene Neighboring gene islet amyloid polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E6502 Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 Neighboring gene STARR-positive B cell enhancer ABC_E1716 Neighboring gene RecQ protein-like Neighboring gene golgi transport 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PDZK1 regulates organic anion transporting polypeptide Oatp1a in mouse small intestine. Sugiura T, et al. Drug Metab Pharmacokinet, 2010. PMID 21084765
  2. The superfamily of organic anion transporting polypeptides. Hagenbuch B, et al. Biochim Biophys Acta, 2003 Jan 10. PMID 12507753
  3. Expression, transport properties, and chromosomal location of organic anion transporter subtype 3. Walters HC, et al. Am J Physiol Gastrointest Liver Physiol, 2000 Dec. PMID 11093941
  4. Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs. van de Steeg E, et al. J Clin Invest, 2010 Aug. PMID 20644253, Free PMC Article
  5. Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion. Di Cosmo C, et al. J Clin Invest, 2010 Sep. PMID 20679730, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables bile acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bile acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables monocarboxylic acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium-independent organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thyroid hormone transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in bile acid and bile salt transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in bile acid and bile salt transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intestinal absorption ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monocarboxylic acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in organic anion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
solute carrier organic anion transporter family member 1A5
Names
organic anion-transporting polypeptide 3
sodium-independent organic anion transporter 3
solute carrier family 21 (organic anion transporter), member 7
solute carrier family 21 member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267707.1 → NP_001254636.1  solute carrier organic anion transporter family member 1A5

    See identical proteins and their annotated locations for NP_001254636.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC102125, FQ790388
    Consensus CDS
    CCDS57464.1
    UniProtKB/Swiss-Prot
    Q91XS2, Q91YY5
    UniProtKB/TrEMBL
    A0A0G2JDD1
    Related
    ENSMUSP00000137607.2, ENSMUST00000111825.10
    Conserved Domains (3) summary
    cd06174
    Location:23 → 397
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:436 → 488
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    TIGR00805
    Location:1 → 625
    oat; sodium-independent organic anion transporter

  2. NM_130861.3 → NP_570931.1  solute carrier organic anion transporter family member 1A5

    See identical proteins and their annotated locations for NP_570931.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK029706
    Consensus CDS
    CCDS57464.1
    UniProtKB/Swiss-Prot
    Q91XS2, Q91YY5
    UniProtKB/TrEMBL
    A0A0G2JDD1
    Related
    ENSMUSP00000080116.4, ENSMUST00000081380.10
    Conserved Domains (3) summary
    cd06174
    Location:23 → 397
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:436 → 488
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    TIGR00805
    Location:1 → 625
    oat; sodium-independent organic anion transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    142179953..142268707 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91YY5.1 GenPept UniProtKB/Swiss-Prot:Q91YY5

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