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Rnf144a ring finger protein 144A [ Mus musculus (house mouse) ]

Gene ID: 108089, updated on 21-Apr-2024

Summary

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Official Symbol
Rnf144aprovided by MGI
Official Full Name
ring finger protein 144Aprovided by MGI
Primary source
MGI:MGI:1344401
See related
Ensembl:ENSMUSG00000020642 AllianceGenome:MGI:1344401
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UIP4; Rnf144; Ubce7ip4
Summary
Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of ubiquitin ligase complex. Predicted to be active in Golgi apparatus. Orthologous to human RNF144A (ring finger protein 144A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 29.8), limb E14.5 (RPKM 11.1) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 A2; 12 9.69 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (26356796..26465296, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (26306794..26415319, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29687 Neighboring gene STARR-seq mESC enhancer starr_31786 Neighboring gene RIKEN cDNA 4930480M12 gene Neighboring gene predicted gene, 29968 Neighboring gene RIKEN cDNA 4930549C15 gene Neighboring gene STARR-seq mESC enhancer starr_31787 Neighboring gene microRNA 6538 Neighboring gene radical S-adenosyl methionine domain containing 2 Neighboring gene cytidine/uridine monophosphate kinase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RNF144A deficiency promotes PD-L1 protein stabilization and carcinogen-induced bladder tumorigenesis. Ho SR, et al. Cancer Lett, 2021 Nov 1. PMID 34400221, Free PMC Article
  2. RNF144A sustains EGFR signaling to promote EGF-dependent cell proliferation. Ho SR, et al. J Biol Chem, 2018 Oct 19. PMID 30171075, Free PMC Article
  3. RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage. Ho SR, et al. Proc Natl Acad Sci U S A, 2014 Jul 1. PMID 24979766, Free PMC Article
  4. A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4. Martinez-Noel G, et al. FEBS Lett, 1999 Jul 9. PMID 10431818
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNF144A promotes antiviral responses by modulating STING ubiquitination.
    Title: RNF144A promotes antiviral responses by modulating STING ubiquitination.
  2. RNF144A deficiency promotes PD-L1 protein stabilization and carcinogen-induced bladder tumorigenesis.
    Title: RNF144A deficiency promotes PD-L1 protein stabilization and carcinogen-induced bladder tumorigenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in pattern recognition receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K6-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF144A
Names
probable E3 ubiquitin-protein ligase RNF144A
ubcM4-interacting protein 4
ubiquitin-conjugating enzyme 7-interacting protein 4
NP_001075446.1
NP_001400409.1
NP_001400410.1
NP_001400411.1
NP_001400412.1
NP_001400413.1
NP_001400414.1
NP_001400415.1
NP_542130.1
XP_006515007.1
XP_030102368.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081977.3 → NP_001075446.1  E3 ubiquitin-protein ligase RNF144A isoform 1

    See identical proteins and their annotated locations for NP_001075446.1

    Status: VALIDATED

    Source sequence(s)
    AC156798
    Consensus CDS
    CCDS36425.1
    UniProtKB/Swiss-Prot
    Q3UZZ0, Q6A0B4, Q925F3
    Related
    ENSMUSP00000020971.7, ENSMUST00000020971.14
    Conserved Domains (3) summary
    smart00647
    Location:91 → 156
    IBR; In Between Ring fingers
    cd16777
    Location:19 → 72
    mRING-HC-C4C4_RBR_RNF144A; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144A (RNF144A)
    pfam01485
    Location:179 → 216
    IBR; IBR domain, a half RING-finger domain

  2. NM_001413480.1 → NP_001400409.1  E3 ubiquitin-protein ligase RNF144A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC156798
    UniProtKB/Swiss-Prot
    Q3UZZ0, Q6A0B4, Q925F3

  3. NM_001413481.1 → NP_001400410.1  E3 ubiquitin-protein ligase RNF144A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC156798
    UniProtKB/Swiss-Prot
    Q3UZZ0, Q6A0B4, Q925F3

  4. NM_001413482.1 → NP_001400411.1  E3 ubiquitin-protein ligase RNF144A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC156798
    UniProtKB/Swiss-Prot
    Q3UZZ0, Q6A0B4, Q925F3

  5. NM_001413483.1 → NP_001400412.1  E3 ubiquitin-protein ligase RNF144A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC156798
    UniProtKB/Swiss-Prot
    Q3UZZ0, Q6A0B4, Q925F3

  6. NM_001413484.1 → NP_001400413.1  E3 ubiquitin-protein ligase RNF144A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC156798
    UniProtKB/Swiss-Prot
    Q3UZZ0, Q6A0B4, Q925F3

  7. NM_001413485.1 → NP_001400414.1  E3 ubiquitin-protein ligase RNF144A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC156798
    UniProtKB/Swiss-Prot
    Q3UZZ0, Q6A0B4, Q925F3

  8. NM_001413486.1 → NP_001400415.1  E3 ubiquitin-protein ligase RNF144A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC156798

  9. NM_080563.5 → NP_542130.1  E3 ubiquitin-protein ligase RNF144A isoform 1

    See identical proteins and their annotated locations for NP_542130.1

    Status: VALIDATED

    Source sequence(s)
    AC156798
    Consensus CDS
    CCDS36425.1
    UniProtKB/Swiss-Prot
    Q3UZZ0, Q6A0B4, Q925F3
    Related
    ENSMUSP00000056073.5, ENSMUST00000062149.6
    Conserved Domains (3) summary
    smart00647
    Location:91 → 156
    IBR; In Between Ring fingers
    cd16777
    Location:19 → 72
    mRING-HC-C4C4_RBR_RNF144A; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144A (RNF144A)
    pfam01485
    Location:179 → 216
    IBR; IBR domain, a half RING-finger domain

RNA

  1. NR_182154.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156798

  2. NR_182155.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156798

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    26356796..26465296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514944.5 → XP_006515007.1  E3 ubiquitin-protein ligase RNF144A isoform X1

    Conserved Domains (3) summary
    smart00647
    Location:112 → 177
    IBR; In Between Ring fingers
    cd16777
    Location:40 → 93
    mRING-HC-C4C4_RBR_RNF144A; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144A (RNF144A)
    pfam01485
    Location:200 → 237
    IBR; IBR domain, a half RING-finger domain

  2. XM_030246508.1 → XP_030102368.1  E3 ubiquitin-protein ligase RNF144A isoform X2

    UniProtKB/Swiss-Prot
    Q3UZZ0, Q6A0B4, Q925F3
    Conserved Domains (3) summary
    smart00647
    Location:91 → 156
    IBR; In Between Ring fingers
    cd16777
    Location:19 → 72
    mRING-HC-C4C4_RBR_RNF144A; Modified RING finger, HC subclass (C4C4-type), found in RING finger protein 144A (RNF144A)
    pfam01485
    Location:179 → 216
    IBR; IBR domain, a half RING-finger domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q925F3.1 GenPept UniProtKB/Swiss-Prot:Q925F3

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