U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Grm7 glutamate receptor, metabotropic 7 [ Mus musculus (house mouse) ]

Gene ID: 108073, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Grm7provided by MGI
Official Full Name
glutamate receptor, metabotropic 7provided by MGI
Primary source
MGI:MGI:1351344
See related
Ensembl:ENSMUSG00000056755 AllianceGenome:MGI:1351344
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SMN2; Gpr1g; Gprc1g; mGluR7; C030018L03; 6330570A01Rik; E130018M02Rik; Tg(SMN2)89Ahmb
Summary
Enables calcium channel regulator activity and voltage-gated calcium channel activity. Involved in chemical synaptic transmission and regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including behavioral fear response; learning or memory; and transmission of nerve impulse. Located in glutamatergic synapse and presynaptic membrane. Is expressed in several structures, including alimentary system; brain; eye; reproductive system; and spinal cord. Orthologous to human GRM7 (glutamate metabotropic receptor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 6.5), frontal lobe adult (RPKM 4.9) and 6 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
6 E3; 6 51.19 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (110622304..111544191)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (110645349..111567230)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35467 Neighboring gene STARR-seq mESC enhancer starr_16994 Neighboring gene STARR-seq mESC enhancer starr_16995 Neighboring gene STARR-seq mESC enhancer starr_16996 Neighboring gene STARR-seq mESC enhancer starr_16997 Neighboring gene D-tyrosyl-tRNA deacylase 1 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_16998 Neighboring gene STARR-seq mESC enhancer starr_16999 Neighboring gene predicted gene 20387 Neighboring gene STARR-seq mESC enhancer starr_17000 Neighboring gene STARR-seq mESC enhancer starr_17001 Neighboring gene STARR-seq mESC enhancer starr_17002 Neighboring gene STARR-seq mESC enhancer starr_17005 Neighboring gene STARR-seq mESC enhancer starr_17006 Neighboring gene STARR-seq mESC enhancer starr_17008 Neighboring gene STARR-seq mESC enhancer starr_17009 Neighboring gene STARR-seq mESC enhancer starr_17010 Neighboring gene RIKEN cDNA 1700054K19 gene Neighboring gene STARR-seq mESC enhancer starr_17012 Neighboring gene STARR-seq mESC enhancer starr_17013 Neighboring gene RIKEN cDNA 5031434C07 gene Neighboring gene STARR-seq mESC enhancer starr_17014 Neighboring gene LIM and cysteine-rich domains 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Spinal Transection Switches the Effect of Metabotropic Glutamate Receptor Subtype 7 from the Facilitation to Inhibition of Ejaculation. Masugi-Tokita M, et al. Neuroscience, 2023 Jan 15. PMID 36403690
  2. Metabotropic Glutamate Receptor Subtype 7 Is Essential for Ejaculation. Masugi-Tokita M, et al. Mol Neurobiol, 2020 Dec. PMID 32865662
  3. Phenotypic profiling of mGlu(7) knockout mice reveals new implications for neurodevelopmental disorders. Fisher NM, et al. Genes Brain Behav, 2020 Sep. PMID 32248644, Free PMC Article
  4. Metabotropic glutamate receptor subtype 7 controls maternal care, maternal motivation and maternal aggression in mice. Gryksa K, et al. Genes Brain Behav, 2020 Jan. PMID 31793148
  5. Increased amygdalar metabotropic glutamate receptor 7 mRNA in a genetic mouse model of impaired fear extinction. O'Connor RM, et al. Psychopharmacology (Berl), 2019 Jan. PMID 30215216, Free PMC Article

See all (228) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PRMT inhibitor promotes SMN2 exon 7 inclusion and synergizes with nusinersen to rescue SMA mice.
    Title: PRMT inhibitor promotes SMN2 exon 7 inclusion and synergizes with nusinersen to rescue SMA mice.
  2. A spinal muscular atrophy modifier implicates the SMN protein in SNARE complex assembly at neuromuscular synapses.
    Title: A spinal muscular atrophy modifier implicates the SMN protein in SNARE complex assembly at neuromuscular synapses.
  3. A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes.
    Title: A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes.
  4. Phenotypic profiling of mGlu7 knockout mice reveals new implications for neurodevelopmental disorders.
    Title: Phenotypic profiling of mGlu(7) knockout mice reveals new implications for neurodevelopmental disorders.
  5. Metabotropic Glutamate Receptor Subtype 7 Is Essential for Ejaculation.
    Title: Metabotropic Glutamate Receptor Subtype 7 Is Essential for Ejaculation.
  6. Metabotropic glutamate receptor subtype 7 controls maternal care, maternal motivation and maternal aggression in mice.
    Title: Metabotropic glutamate receptor subtype 7 controls maternal care, maternal motivation and maternal aggression in mice.
  7. A transsynaptic interaction between Elfn1 and mGluR7 constitutively reduces initial release probability onto mouse cortical SOM neurons. Elfn1 produces glutamate-independent activation of mGluR7 via presynaptic clustering, resulting in a divergence from the canonical "autoreceptor" role of Type III mGluRs, and substantially altering synaptic pharmacology.
    Title: Elfn1-Induced Constitutive Activation of mGluR7 Determines Frequency-Dependent Recruitment of Somatostatin Interneurons.
  8. mGlu7 is not functionally increased in mice overexpressing MeCP2 and that neither genetic nor pharmacological reduction of mGlu7 activity impacts phenotypes in a mouse model of MeCP2 duplication syndrome.
    Title: Genetic Reduction or Negative Modulation of mGlu(7) Does Not Impact Anxiety and Fear Learning Phenotypes in a Mouse Model of MECP2 Duplication Syndrome.
  9. We found a significant reduction of testosterone levels in mGluR7 knockout (KO) mice. Social investigating behaviour of intact mGluR7 KO mice also differed from that of wild-type mice; e.g. the KO mice showing less frequent anogenital sniffing and more frequent grooming behaviour. Further, castrated mGluR7 KO mice have smaller seminal vesicles than those of castrated wild-type mice, although intact mice were no different.
    Title: Metabotropic glutamate receptor subtype 7 has critical roles in regulation of the endocrine system and social behaviours.
  10. Altered mGlu7 expression was found in brain regions associated with fear extinction in two different mouse strains which differ in their fear extinction behavior.
    Title: Increased amygdalar metabotropic glutamate receptor 7 mRNA in a genetic mouse model of impaired fear extinction.
Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC90857

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables PDZ domain binding TAS
Traceable Author Statement
more info
 PubMed 
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables adenylate cyclase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium channel regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
  
enables glutamate binding ISO
Inferred from Sequence Orthology
more info
  
enables glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables group III metabotropic glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables group III metabotropic glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables group III metabotropic glutamate receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein dimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables serine binding ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within adult behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within associative learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within behavioral fear response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within conditioned taste aversion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycosylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organismal response to stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of glutamate secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nervous system process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in presynaptic modulation of chemical synaptic transmission EXP
Inferred from Experiment
more info
 PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within short-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transmission of nerve impulse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in asymmetric synapse ISO
Inferred from Sequence Orthology
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
  
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in presynaptic active zone ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
  
located_in presynaptic active zone membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
metabotropic glutamate receptor 7
Names
G protein-coupled receptor GRM7
G protein-coupled receptor, family C, group 1, member G
mGlu7a receptor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346640.1 → NP_001333569.1  metabotropic glutamate receptor 7 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC114643, AC125046, AC132394, AC142264, AC169981, AC169984
    Consensus CDS
    CCDS85110.1
    UniProtKB/TrEMBL
    G5E8D5
    Related
    ENSMUSP00000064404.7, ENSMUST00000071076.13
    Conserved Domains (3) summary
    cd15451
    Location:589 → 895
    7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06376
    Location:43 → 511
    PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
    pfam07562
    Location:519 → 569
    NCD3G; Nine Cysteines Domain of family 3 GPCR

  2. NM_177328.3 → NP_796302.2  metabotropic glutamate receptor 7 isoform 1 precursor

    See identical proteins and their annotated locations for NP_796302.2

    Status: VALIDATED

    Source sequence(s)
    AC114643, AC125046, AC132394, AC142264, AC169981, AC169984
    Consensus CDS
    CCDS39587.1
    UniProtKB/Swiss-Prot
    Q68ED2
    Related
    ENSMUSP00000133957.2, ENSMUST00000172951.2
    Conserved Domains (3) summary
    cd15451
    Location:589 → 895
    7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06376
    Location:43 → 511
    PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
    pfam07562
    Location:519 → 569
    NCD3G; Nine Cysteines Domain of family 3 GPCR

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    110622304..111544191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505296.3 → XP_006505359.1  metabotropic glutamate receptor 7 isoform X1

    Conserved Domains (3) summary
    cd15451
    Location:589 → 895
    7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:519 → 569
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd06376
    Location:43 → 511
    PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

  2. XM_017321298.3 → XP_017176787.1  metabotropic glutamate receptor 7 isoform X1

    Conserved Domains (3) summary
    cd15451
    Location:589 → 895
    7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:519 → 569
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd06376
    Location:43 → 511
    PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

  3. XM_006505298.4 → XP_006505361.1  metabotropic glutamate receptor 7 isoform X2

    See identical proteins and their annotated locations for XP_006505361.1

    UniProtKB/TrEMBL
    G5E8D5
    Conserved Domains (3) summary
    cd15451
    Location:589 → 895
    7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06376
    Location:43 → 511
    PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
    pfam07562
    Location:519 → 569
    NCD3G; Nine Cysteines Domain of family 3 GPCR

  4. XM_006505301.3 → XP_006505364.1  metabotropic glutamate receptor 7 isoform X4

    Conserved Domains (3) summary
    cd15451
    Location:589 → 895
    7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:519 → 569
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd06376
    Location:43 → 511
    PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

  5. XM_006505300.4 → XP_006505363.1  metabotropic glutamate receptor 7 isoform X3

    Conserved Domains (3) summary
    cd15451
    Location:589 → 895
    7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:519 → 569
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd06376
    Location:43 → 511
    PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

  6. XM_006505302.4 → XP_006505365.1  metabotropic glutamate receptor 7 isoform X5

    Conserved Domains (3) summary
    cd15286
    Location:589 → 817
    7tmC_mGluR_group3; metabotropic glutamate receptors in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:519 → 569
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd06376
    Location:43 → 511
    PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

RNA

  1. XR_003956139.2 RNA Sequence

  2. XR_003956140.2 RNA Sequence

  3. XR_003956142.2 RNA Sequence

  4. XR_003956141.2 RNA Sequence

  5. XR_004942887.1 RNA Sequence

  6. XR_001785078.3 RNA Sequence

  7. XR_001785080.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177970.1: Suppressed sequence

    Description
    NM_177970.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68ED2.1 GenPept UniProtKB/Swiss-Prot:Q68ED2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous