Grm6 glutamate receptor, metabotropic 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grm6provided by MGI
Official Full Name: glutamate receptor, metabotropic 6provided by MGI
Primary source: MGI:MGI:1351343
See related: Ensembl:ENSMUSG00000000617 AllianceGenome:MGI:1351343
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm3; nob2; nob3; nob4; nerg1; Gprc1f; mGluR6
Summary: Predicted to enable adenylate cyclase inhibiting G protein-coupled glutamate receptor activity and protein homodimerization activity. Involved in locomotory behavior and sensory perception of light stimulus. Acts upstream of or within retina development in camera-type eye and signal transduction. Located in new growing cell tip. Is expressed in prostate gland; retina inner nuclear layer; and testis. Used to study congenital stationary night blindness 1B. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1B. Orthologous to human GRM6 (glutamate metabotropic receptor 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 30.93 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (50741205..50757035)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (50850369..50866208)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Soluble PD-L1 reprograms blood monocytes to prevent cerebral edema and facilitate recovery after ischemic stroke.
Title: Soluble PD-L1 reprograms blood monocytes to prevent cerebral edema and facilitate recovery after ischemic stroke.
The mGluR6 ligand-binding domain, but not the C-terminal domain, is required for synaptic localization in retinal ON-bipolar cells.
Title: The mGluR6 ligand-binding domain, but not the C-terminal domain, is required for synaptic localization in retinal ON-bipolar cells.
Mislocalization of mutant mGluR6 is not normalized by reducing the total mGluR6.
Title: Reduced expression of the nob8 gene does not normalize the distribution or function of mGluR6 in the mouse retina.
Laminar size and structure in missense Grm6(nob8) retina were comparable to control. The Grm6(nob8) phenotype is distinguished from other Grm6 mutants that carry a null allele by a reduced but not absent electroretinograph b-wave, decreased but present expression of mGluR6 at retinal depolarizing bipolar cells (DBCs) dendritic tips, and mislocalization of mGluR6 to DBC somas. In p.Met66Leu mutant mGluR6 is trafficked less
Title: A missense mutation in Grm6 reduces but does not eliminate mGluR6 expression or rod depolarizing bipolar cell function.
Study suggests that the mGluR6 macromolecular complex is connected to the presynaptic rod terminal via a protein chain that includes the matrix-associated proteins. When a component of the macromolecular chain is missing, the chain may fall apart and loosen the dendritic tip adherence within the invagination.
Title: Lack of mGluR6-related cascade elements leads to retrograde trans-synaptic effects on rod photoreceptor synapses via matrix-associated proteins.
These results indicate that Grm6 nob7 is a new model of the complete form of congenital stationary night blindness.
Title: Identification of a new mutant allele, Grm6(nob7), for complete congenital stationary night blindness.
The mGluR6-KO phenotype showed negative effects on ribbon synapse formation.
Title: Effects of mGluR6-deficiency on photoreceptor ribbon synapse formation: comparison of electron microscopic analysis of serial sections with random sections.
Diagnosis of concurrent Stargardt disease and CSNB was made on the ophthalmic history; genetic testing revealed two previously reported mutations in the ABCA4 gene and two novel deletions in the GRM6 gene.
Title: Sorting out co-occurrence of rare monogenic retinopathies: Stargardt disease co-existing with congenital stationary night blindness.
the localization and stability of Cacna1s depend on the expression of mGluR6 and its cascade components, and they suggest that Cacna1s is part of the mGluR6 complex.
Title: Localization of Cacna1s to ON bipolar dendritic tips requires mGluR6-related cascade elements.
The results suggested that the TRPM1 channel in metabotropic glutamate receptor 6-null rod bipolar cells is inactive. Rod bipolar cells in metabotropic glutamate receptor 6-null mice were hyperpolarized.
Title: mGluR6 deletion renders the TRPM1 channel in retina inactive.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (3) 1 citation
Targeted (3) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Pjn3 (e-PCR), detects polymorphism
- UniSTS:498689

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables group III metabotropic glutamate receptor activity	TAS Traceable Author Statement more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled glutamate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in detection of light stimulus involved in visual perception	ISO Inferred from Sequence Orthology more info
involved_in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in visual perception	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cell tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in new growing cell tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: metabotropic glutamate receptor 6

Names: G protein-coupled receptor GRM6; G protein-coupled receptor, family C, group 1, member F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173372.2 → NP_775548.2 metabotropic glutamate receptor 6 precursor

See identical proteins and their annotated locations for NP_775548.2

Status: VALIDATED

Source sequence(s)

BC041684, BC152480, BG293080

Consensus CDS

CCDS48785.1

UniProtKB/Swiss-Prot

Q5NCH9

Related

ENSMUSP00000130728.2, ENSMUST00000171427.8

Conserved Domains (4) summary

cd06376
Location:39 → 500

PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

pfam07562
Location:508 → 558

NCD3G; Nine Cysteines Domain of family 3 GPCR

cd14964
Location:578 → 603

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:578 → 850

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

50741205..50757035

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156219.1 → XP_036012112.1 metabotropic glutamate receptor 6 isoform X3

UniProtKB/Swiss-Prot

Q5NCH9

Conserved Domains (4) summary

cd06376
Location:39 → 500

PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

pfam07562
Location:508 → 558

NCD3G; Nine Cysteines Domain of family 3 GPCR

cd14964
Location:578 → 603

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:578 → 850

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006531964.2 → XP_006532027.1 metabotropic glutamate receptor 6 isoform X2

Conserved Domains (4) summary

cd14964
Location:204 → 229

7tm_GPCRs; TM helix 1 [structural motif]

pfam07562
Location:134 → 184

NCD3G; Nine Cysteines Domain of family 3 GPCR

cl10011
Location:4 → 126

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

cl28897
Location:204 → 476

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_017314218.2 → XP_017169707.1 metabotropic glutamate receptor 6 isoform X1

UniProtKB/TrEMBL

Q8CFQ7

Related

ENSMUST00000126890.2

Conserved Domains (4) summary

cd14964
Location:254 → 278

7tm_GPCRs; TM helix 1 [structural motif]

pfam07562
Location:183 → 233

NCD3G; Nine Cysteines Domain of family 3 GPCR

cl10011
Location:1 → 175

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

cl28897
Location:253 → 525

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily