Eif2b3 eukaryotic translation initiation factor 2B, subunit 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eif2b3provided by MGI
Official Full Name: eukaryotic translation initiation factor 2B, subunit 3provided by MGI
Primary source: MGI:MGI:1313286
See related: Ensembl:ENSMUSG00000028683 AllianceGenome:MGI:1313286
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1190002P15Rik
Summary: Predicted to enable guanyl-nucleotide exchange factor activity and translation initiation factor activity. Predicted to contribute to translation factor activity, RNA binding. Predicted to be involved in several processes, including T cell receptor signaling pathway; cytoplasmic translational initiation; and oligodendrocyte development. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 2B complex and guanyl-nucleotide exchange factor complex. Is expressed in central nervous system; gonad; retina; and thyroid gland. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B3 (eukaryotic translation initiation factor 2B subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E14 (RPKM 4.2), CNS E11.5 (RPKM 4.0) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D1; 4 53.41 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (116876559..116944049)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (117019399..117086852)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
contributes_to translation factor activity, RNA binding	ISO Inferred from Sequence Orthology more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to translation initiation factor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoplasmic translational initiation	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte development	ISO Inferred from Sequence Orthology more info
involved_in response to glucose	ISO Inferred from Sequence Orthology more info
involved_in response to heat	ISO Inferred from Sequence Orthology more info
involved_in response to peptide hormone	ISO Inferred from Sequence Orthology more info
involved_in translational initiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of eukaryotic translation initiation factor 2B complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 2B complex	ISO Inferred from Sequence Orthology more info
part_of guanyl-nucleotide exchange factor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: translation initiation factor eIF2B subunit gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001111277.2 → NP_001104747.1 translation initiation factor eIF2B subunit gamma isoform 1

See identical proteins and their annotated locations for NP_001104747.1

Status: VALIDATED

Source sequence(s)

AK145856, BC115657, BE952243, BQ828648, BY277686

Consensus CDS

CCDS51279.1

UniProtKB/TrEMBL

B1AUN2, B1AUN3

Related

ENSMUSP00000102056.3, ENSMUST00000106448.9

Conserved Domains (3) summary

cd04652
Location:357 → 437

LbH_eIF2B_gamma_C; eIF-2B gamma subunit, C-terminal Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is ...

cd04198
Location:3 → 212

eIF-2B_gamma_N; The N-terminal domain of gamma subunit of the eIF-2B is a subfamily of glycosyltransferase 2

COG1208
Location:4 → 447

GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]
NM_001355225.1 → NP_001342154.1 translation initiation factor eIF2B subunit gamma isoform 3

Status: VALIDATED

Source sequence(s)

AK145856, BE952243, BM945817, BQ176818, BQ828648, BY277686, DV041891

Conserved Domains (1) summary

cd04652
Location:142 → 222

LbH_eIF2B_gamma_C; eIF-2B gamma subunit, C-terminal Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is ...
NM_175135.5 → NP_780344.2 translation initiation factor eIF2B subunit gamma isoform 2

See identical proteins and their annotated locations for NP_780344.2

Status: VALIDATED

Source sequence(s)

AK145856, AK165157, BQ828648, BY277686

Consensus CDS

CCDS18524.1

UniProtKB/TrEMBL

B1AUN3, Q3UKV0

Related

ENSMUSP00000102055.3, ENSMUST00000106447.9

Conserved Domains (3) summary

cd04198
Location:3 → 212

eIF-2B_gamma_N; The N-terminal domain of gamma subunit of the eIF-2B is a subfamily of glycosyltransferase 2

COG1208
Location:4 → 399

GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]

cl00160
Location:357 → 401

LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

116876559..116944049

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006502649.3 → XP_006502712.1 translation initiation factor eIF2B subunit gamma isoform X1

UniProtKB/TrEMBL

B1AUN3

Conserved Domains (2) summary

cd04198
Location:3 → 212

eIF-2B_gamma_N; The N-terminal domain of gamma subunit of the eIF-2B is a subfamily of glycosyltransferase 2

cl00160
Location:357 → 401

LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...