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Cstf2 cleavage stimulation factor, 3' pre-RNA subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 108062, updated on 5-Mar-2024

Summary

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Official Symbol
Cstf2provided by MGI
Official Full Name
cleavage stimulation factor, 3' pre-RNA subunit 2provided by MGI
Primary source
MGI:MGI:1343054
See related
Ensembl:ENSMUSG00000031256 AllianceGenome:MGI:1343054
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cstf64; mir-3112; C630034J23Rik
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in pre-mRNA cleavage required for polyadenylation. Predicted to act upstream of or within mRNA processing. Predicted to be located in cleavage body. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human CSTF2 (cleavage stimulation factor subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 16.0), CNS E18 (RPKM 16.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cstf2 in Genome Data Viewer
Location:
X E3; X 55.63 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (132959925..132987571)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (134059176..134086822)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene synaptotagmin-like 4 Neighboring gene predicted gene 7841 Neighboring gene microRNA 3112 Neighboring gene predicted gene, 54083 Neighboring gene NADPH oxidase 1 Neighboring gene X-linked Kx blood group related, X-linked

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CstF-64 is necessary for endoderm differentiation resulting in cardiomyocyte defects. Youngblood BA, et al. Stem Cell Res, 2014 Nov. PMID 25460602, Free PMC Article
  2. CstF-64 supports pluripotency and regulates cell cycle progression in embryonic stem cells through histone 3' end processing. Youngblood BA, et al. Nucleic Acids Res, 2014 Jul. PMID 24957598, Free PMC Article
  3. Dynamic nature of cleavage bodies and their spatial relationship to DDX1 bodies, Cajal bodies, and gems. Li L, et al. Mol Biol Cell, 2006 Mar. PMID 16371507, Free PMC Article
  4. CstF64: cell cycle regulation and functional role in 3' end processing of replication-dependent histone mRNAs. Romeo V, et al. Mol Cell Biol, 2014 Dec 1. PMID 25266659, Free PMC Article
  5. Polyadenylation proteins CstF-64 and tauCstF-64 exhibit differential binding affinities for RNA polymers. Monarez RR, et al. Biochem J, 2007 Feb 1. PMID 17029590, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results suggest that CstF-64 plays a key role in modulating the cell cycle in embryonic stem cells while simultaneously controlling histone mRNA 3' end processing.
    Title: CstF-64 supports pluripotency and regulates cell cycle progression in embryonic stem cells through histone 3' end processing.
  2. ELL2 and CstF-64 tracked together with RNA polymerase II across the Igh mu- and gamma-gene segments
    Title: Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cleavage body ISO
Inferred from Sequence Orthology
more info
  
part_of mRNA cleavage and polyadenylation specificity factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mRNA cleavage and polyadenylation specificity factor complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cleavage stimulation factor subunit 2
Names
CF-1 64 kDa subunit
CSTF 64 kDa subunit
cleavage stimulation factor, 3' pre-RNA subunit 2, 64 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290398.1 → NP_001277327.1  cleavage stimulation factor subunit 2 isoform 2

    See identical proteins and their annotated locations for NP_001277327.1

    Status: VALIDATED

    Source sequence(s)
    AI850965, AK049971, AK147438, CJ183629
    Consensus CDS
    CCDS72430.1
    UniProtKB/TrEMBL
    A2AEK1, B3V099
    Related
    ENSMUSP00000108912.2, ENSMUST00000113287.8
    Conserved Domains (4) summary
    COG0724
    Location:16 → 104
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12671
    Location:18 → 92
    RRM_CSTF2_CSTF2T; RNA recognition motif in cleavage stimulation factor subunit 2 (CSTF2), cleavage stimulation factor subunit 2 tau variant (CSTF2T) and similar proteins
    pfam14304
    Location:510 → 550
    CSTF_C; Transcription termination and cleavage factor C-terminal
    pfam14327
    Location:113 → 191
    CSTF2_hinge; Hinge domain of cleavage stimulation factor subunit 2

  2. NM_001290399.1 → NP_001277328.1  cleavage stimulation factor subunit 2 isoform 3

    See identical proteins and their annotated locations for NP_001277328.1

    Status: VALIDATED

    Source sequence(s)
    AK032817, AL671915, BE953679, CJ183629
    Consensus CDS
    CCDS81170.1
    UniProtKB/TrEMBL
    B3V097
    Related
    ENSMUSP00000108911.2, ENSMUST00000113286.8
    Conserved Domains (4) summary
    PRK14718
    Location:395 → 452
    PRK14718; ribonuclease III; Provisional
    pfam09606
    Location:183 → 401
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam14327
    Location:112 → 191
    CSTF2_hinge; Hinge domain of cleavage stimulation factor subunit 2
    cd12671
    Location:10 → 94
    RRM_CSTF2_CSTF2T; RNA recognition motif (RRM) found in cleavage stimulation factor subunit 2 (CSTF2), cleavage stimulation factor subunit 2 tau variant (CSTF2T) and similar proteins

  3. NM_001359053.1 → NP_001345982.1  cleavage stimulation factor subunit 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AI850965, AL671915
    UniProtKB/TrEMBL
    B3V099
    Conserved Domains (5) summary
    cd12671
    Location:18 → 92
    RRM_CSTF2_CSTF2T; RNA recognition motif in cleavage stimulation factor subunit 2 (CSTF2), cleavage stimulation factor subunit 2 tau variant (CSTF2T) and similar proteins
    pfam14304
    Location:559 → 599
    CSTF_C; Transcription termination and cleavage factor C-terminal
    pfam14327
    Location:113 → 191
    CSTF2_hinge; Hinge domain of cleavage stimulation factor subunit 2
    cl25887
    Location:7 → 332
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cl25983
    Location:418 → 475
    Rnc; dsRNA-specific ribonuclease [Transcription]

  4. NM_001359054.1 → NP_001345983.1  cleavage stimulation factor subunit 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AI850965, AL671915
    UniProtKB/TrEMBL
    B3V099
    Conserved Domains (4) summary
    cd12671
    Location:18 → 92
    RRM_CSTF2_CSTF2T; RNA recognition motif in cleavage stimulation factor subunit 2 (CSTF2), cleavage stimulation factor subunit 2 tau variant (CSTF2T) and similar proteins
    pfam14304
    Location:530 → 570
    CSTF_C; Transcription termination and cleavage factor C-terminal
    pfam14327
    Location:113 → 191
    CSTF2_hinge; Hinge domain of cleavage stimulation factor subunit 2
    cl25887
    Location:18 → 447
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  5. NM_133196.6 → NP_573459.1  cleavage stimulation factor subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_573459.1

    Status: VALIDATED

    Source sequence(s)
    AI850965, AK032817, AK147438, AL671915, CJ183629
    Consensus CDS
    CCDS30389.1
    UniProtKB/Swiss-Prot
    A2AEJ9, A2AEK0, Q8BIQ5, Q8K1Y6, Q9ERC2
    UniProtKB/TrEMBL
    B3V099
    Related
    ENSMUSP00000033609.3, ENSMUST00000033609.9
    Conserved Domains (4) summary
    COG0724
    Location:16 → 104
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12671
    Location:18 → 92
    RRM_CSTF2_CSTF2T; RNA recognition motif in cleavage stimulation factor subunit 2 (CSTF2), cleavage stimulation factor subunit 2 tau variant (CSTF2T) and similar proteins
    pfam14304
    Location:536 → 576
    CSTF_C; Transcription termination and cleavage factor C-terminal
    pfam14327
    Location:113 → 191
    CSTF2_hinge; Hinge domain of cleavage stimulation factor subunit 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    132959925..132987571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BIQ5.2 GenPept UniProtKB/Swiss-Prot:Q8BIQ5

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