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Gtpbp6 GTP binding protein 6 (putative) [ Mus musculus (house mouse) ]

Gene ID: 107999, updated on 5-Mar-2024

Summary

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Official Symbol
Gtpbp6provided by MGI
Official Full Name
GTP binding protein 6 (putative)provided by MGI
Primary source
MGI:MGI:1306825
See related
Ensembl:ENSMUSG00000033434 AllianceGenome:MGI:1306825
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
pgpl; Pgbpll
Summary
Predicted to enable ribosome binding activity. Predicted to be active in cytoplasm. Orthologous to human GTPBP6 (GTP binding protein 6 (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 45.4), thymus adult (RPKM 43.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 53.3 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (110251842..110256063, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (110103976..110108331, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13942 Neighboring gene predicted gene, 35315 Neighboring gene STARR-positive B cell enhancer ABC_E3596 Neighboring gene predicted gene, 54335 Neighboring gene STARR-positive B cell enhancer ABC_E4778 Neighboring gene STARR-positive B cell enhancer ABC_E10339 Neighboring gene phosphatidylinositol-specific phospholipase C, X domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E3597 Neighboring gene zinc finger protein 605 Neighboring gene nucleophosmin pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6362 Neighboring gene STARR-seq mESC enhancer starr_13946 Neighboring gene checkpoint with forkhead and ring finger domains Neighboring gene predicted gene 15787

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential divergence of three human pseudoautosomal genes and their mouse homologs: implications for sex chromosome evolution. Gianfrancesco F, et al. Genome Res, 2001 Dec. PMID 11731500, Free PMC Article
  2. A novel pseudoautosomal gene encoding a putative GTP-binding protein resides in the vicinity of the Xp/Yp telomere. Gianfrancesco F, et al. Hum Mol Genet, 1998 Mar. PMID 9466997
  3. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative GTP-binding protein 6
Names
pseudoautosomal GTP binding protein-like, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145147.5 → NP_660129.2  putative GTP-binding protein 6

    See identical proteins and their annotated locations for NP_660129.2

    Status: VALIDATED

    Source sequence(s)
    AK082192, AK152225
    Consensus CDS
    CCDS51604.1
    UniProtKB/Swiss-Prot
    Q3TX13, Q3U6U5, Q3UMM2
    UniProtKB/TrEMBL
    A0A0R4J0Z0
    Related
    ENSMUSP00000076458.8, ENSMUST00000077220.14
    Conserved Domains (3) summary
    cd01878
    Location:272 → 443
    HflX; HflX GTPase family
    COG2262
    Location:101 → 503
    HflX; 50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]
    pfam13167
    Location:111 → 197
    GTP-bdg_N; GTP-binding GTPase N-terminal

RNA

  1. NR_189623.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC166747

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    110251842..110256063 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254041.2 → XP_030109901.1  putative GTP-binding protein 6 isoform X4

    UniProtKB/TrEMBL
    Q8K372
    Conserved Domains (1) summary
    cd01878
    Location:65 → 236
    HflX; HflX GTPase family

  2. XM_036164716.1 → XP_036020609.1  putative GTP-binding protein 6 isoform X4

    UniProtKB/TrEMBL
    Q8K372
    Conserved Domains (1) summary
    cd01878
    Location:65 → 236
    HflX; HflX GTPase family

  3. XM_006534697.3 → XP_006534760.1  putative GTP-binding protein 6 isoform X1

    UniProtKB/TrEMBL
    Q8VDE1
    Conserved Domains (1) summary
    COG2262
    Location:3 → 399
    HflX; 50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]

  4. XM_006534701.3 → XP_006534764.1  putative GTP-binding protein 6 isoform X2

    See identical proteins and their annotated locations for XP_006534764.1

    UniProtKB/TrEMBL
    Q8VDE1
    Conserved Domains (2) summary
    cd01878
    Location:113 → 284
    HflX; HflX GTPase family
    pfam16360
    Location:42 → 90
    GTP-bdg_M; GTP-binding GTPase Middle Region

  5. XM_030254037.1 → XP_030109897.1  putative GTP-binding protein 6 isoform X3

    UniProtKB/TrEMBL
    Q8VDE1
    Conserved Domains (1) summary
    COG2262
    Location:3 → 334
    HflX; 50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]

  6. XM_006534700.3 → XP_006534763.1  putative GTP-binding protein 6 isoform X2

    See identical proteins and their annotated locations for XP_006534763.1

    UniProtKB/TrEMBL
    Q8VDE1
    Conserved Domains (2) summary
    cd01878
    Location:113 → 284
    HflX; HflX GTPase family
    pfam16360
    Location:42 → 90
    GTP-bdg_M; GTP-binding GTPase Middle Region

  7. XM_036164714.1 → XP_036020607.1  putative GTP-binding protein 6 isoform X3

    UniProtKB/TrEMBL
    Q8VDE1
    Conserved Domains (1) summary
    COG2262
    Location:3 → 334
    HflX; 50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]

  8. XM_036164713.1 → XP_036020606.1  putative GTP-binding protein 6 isoform X2

    UniProtKB/TrEMBL
    Q8VDE1
    Conserved Domains (2) summary
    cd01878
    Location:113 → 284
    HflX; HflX GTPase family
    pfam16360
    Location:42 → 90
    GTP-bdg_M; GTP-binding GTPase Middle Region

  9. XM_036164715.1 → XP_036020608.1  putative GTP-binding protein 6 isoform X3

    UniProtKB/TrEMBL
    Q8VDE1
    Related
    ENSMUST00000127628.6
    Conserved Domains (1) summary
    COG2262
    Location:3 → 334
    HflX; 50S ribosomal subunit-associated GTPase HflX [Translation, ribosomal structure and biogenesis]

  10. XM_030254040.2 → XP_030109900.1  putative GTP-binding protein 6 isoform X4

    UniProtKB/TrEMBL
    Q8K372
    Conserved Domains (1) summary
    cd01878
    Location:65 → 236
    HflX; HflX GTPase family

  11. XM_036164717.1 → XP_036020610.1  putative GTP-binding protein 6 isoform X4

    UniProtKB/TrEMBL
    Q8K372
    Conserved Domains (1) summary
    cd01878
    Location:65 → 236
    HflX; HflX GTPase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U6U5.1 GenPept UniProtKB/Swiss-Prot:Q3U6U5

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